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Evaluation of polymeric micelles from brush polymer with poly(epsilon-caprolactone)-b-poly(ethylene glycol) side chains as drug carrier.
Biomacromolecules 2009; 10(8):2169-74B

Abstract

Brush polymers PHEMA-g-(PCL-b-PEG) with poly(2-hydroxyethyl methacrylate) (PHEMA) as the backbone and poly(epsilon-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) block copolymers as side chains were synthesized and evaluated as drug delivery vehicles. Two brush polymers were synthesized, and their structures were confirmed by gel permeation chromatography analyses and (1)H NMR measurements. The brush polymers self-assembled into micelles in aqueous solution, and the critical micellization concentrations of brush polymers were 2-fold lower than that of the linear diblock copolymer PCL-b-PEG with structure similar to that of the grafted side chains of brush polymers, indicating the higher aqueous stability of brush polymer micelles. The micelles were spherical with average diameters below 100 nm. Brush polymer micelles exhibited higher loading doxorubicin capacity compared with micelles from linear PCL-b-PEG block copolymer by the dialysis method, and the burst doxorubicin release from the brush polymer micelles was significantly suppressed. Doxorubicin-loaded brush polymer micelles can be effectively internalized by A549 human lung carcinoma cells and slowly released the encapsulated drug molecules as demonstrated by the drug accumulation in cytoplasm, which was opposite to free doxorubicin, which accumulated rapidly in the cell nuclei.

Authors+Show Affiliations

Department of Polymer Science and Engineering, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19722555

Citation

Du, Jin-Zhi, et al. "Evaluation of Polymeric Micelles From Brush Polymer With Poly(epsilon-caprolactone)-b-poly(ethylene Glycol) Side Chains as Drug Carrier." Biomacromolecules, vol. 10, no. 8, 2009, pp. 2169-74.
Du JZ, Tang LY, Song WJ, et al. Evaluation of polymeric micelles from brush polymer with poly(epsilon-caprolactone)-b-poly(ethylene glycol) side chains as drug carrier. Biomacromolecules. 2009;10(8):2169-74.
Du, J. Z., Tang, L. Y., Song, W. J., Shi, Y., & Wang, J. (2009). Evaluation of polymeric micelles from brush polymer with poly(epsilon-caprolactone)-b-poly(ethylene glycol) side chains as drug carrier. Biomacromolecules, 10(8), pp. 2169-74. doi:10.1021/bm900345m.
Du JZ, et al. Evaluation of Polymeric Micelles From Brush Polymer With Poly(epsilon-caprolactone)-b-poly(ethylene Glycol) Side Chains as Drug Carrier. Biomacromolecules. 2009 Aug 10;10(8):2169-74. PubMed PMID: 19722555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of polymeric micelles from brush polymer with poly(epsilon-caprolactone)-b-poly(ethylene glycol) side chains as drug carrier. AU - Du,Jin-Zhi, AU - Tang,Ling-Yan, AU - Song,Wen-Jing, AU - Shi,Yue, AU - Wang,Jun, PY - 2009/9/3/entrez PY - 2009/9/3/pubmed PY - 2009/11/18/medline SP - 2169 EP - 74 JF - Biomacromolecules JO - Biomacromolecules VL - 10 IS - 8 N2 - Brush polymers PHEMA-g-(PCL-b-PEG) with poly(2-hydroxyethyl methacrylate) (PHEMA) as the backbone and poly(epsilon-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) block copolymers as side chains were synthesized and evaluated as drug delivery vehicles. Two brush polymers were synthesized, and their structures were confirmed by gel permeation chromatography analyses and (1)H NMR measurements. The brush polymers self-assembled into micelles in aqueous solution, and the critical micellization concentrations of brush polymers were 2-fold lower than that of the linear diblock copolymer PCL-b-PEG with structure similar to that of the grafted side chains of brush polymers, indicating the higher aqueous stability of brush polymer micelles. The micelles were spherical with average diameters below 100 nm. Brush polymer micelles exhibited higher loading doxorubicin capacity compared with micelles from linear PCL-b-PEG block copolymer by the dialysis method, and the burst doxorubicin release from the brush polymer micelles was significantly suppressed. Doxorubicin-loaded brush polymer micelles can be effectively internalized by A549 human lung carcinoma cells and slowly released the encapsulated drug molecules as demonstrated by the drug accumulation in cytoplasm, which was opposite to free doxorubicin, which accumulated rapidly in the cell nuclei. SN - 1526-4602 UR - https://www.unboundmedicine.com/medline/citation/19722555/Evaluation_of_polymeric_micelles_from_brush_polymer_with_poly_epsilon_caprolactone__b_poly_ethylene_glycol__side_chains_as_drug_carrier_ L2 - https://dx.doi.org/10.1021/bm900345m DB - PRIME DP - Unbound Medicine ER -