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Effect of epidermal growth factor receptor inhibitor alone and in combination with cisplatin on growth of vulvar cancer cells.
Ann N Y Acad Sci. 2009 Aug; 1171:642-8.AN

Abstract

A recent study reported on the efficacy of the EGFR inhibitor on locally advanced vulvar cancer. The aim of this study was to evaluate the effect of an EGFR tyrosine kinase inhibitor (AG1478) alone and in combination with cisplatin on vulvar cancer cells (A431 and SW962). We detected overexpression of EGFR in A431 cells and low expression in SW962 cells. We found that the growth inhibitory effect of AG1478 was dependent upon the expression level of EGFR. The combined treatment of AG1478 with cisplatin failed to exert any synergistic or additive effect in either cell line. In the EGFR signaling pathway, AG1478 decreased the phosphorylation of extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) in parallel with decreased activity of EGFR in A431 cells, while no changes in ERK and Akt were observed in SW962 cells. The combination of AG1478 with cisplatin completely inhibited the phosphorylation of ERK and Akt in A431 cells but not in SW962 cells. Cisplatin alone and its combination with AG1478 increased the phosphorylation of p38 and c-Jun N-terminal kinase (JNK) in both cell lines. In summary, AG1478 inhibited the growth activity of vulvar cancer cells, depending upon the expression level of EGFR, by inhibiting the activities of EGFR, Akt, and ERK. Given the absence of synergistic effects from the combination of AG1478 with cisplatin, combination therapy should be considered cautiously.

Authors+Show Affiliations

Cancer Research Institute, World Class University, Seoul National University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19723115

Citation

Kim, Su-Hyeon, et al. "Effect of Epidermal Growth Factor Receptor Inhibitor Alone and in Combination With Cisplatin On Growth of Vulvar Cancer Cells." Annals of the New York Academy of Sciences, vol. 1171, 2009, pp. 642-8.
Kim SH, Song YC, Kim SH, et al. Effect of epidermal growth factor receptor inhibitor alone and in combination with cisplatin on growth of vulvar cancer cells. Ann N Y Acad Sci. 2009;1171:642-8.
Kim, S. H., Song, Y. C., Kim, S. H., Jo, H., & Song, Y. S. (2009). Effect of epidermal growth factor receptor inhibitor alone and in combination with cisplatin on growth of vulvar cancer cells. Annals of the New York Academy of Sciences, 1171, 642-8. https://doi.org/10.1111/j.1749-6632.2009.04893.x
Kim SH, et al. Effect of Epidermal Growth Factor Receptor Inhibitor Alone and in Combination With Cisplatin On Growth of Vulvar Cancer Cells. Ann N Y Acad Sci. 2009;1171:642-8. PubMed PMID: 19723115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of epidermal growth factor receptor inhibitor alone and in combination with cisplatin on growth of vulvar cancer cells. AU - Kim,Su-Hyeon, AU - Song,Yoo-Cheol, AU - Kim,Su-Hyeong, AU - Jo,Hoenil, AU - Song,Yong-Sang, PY - 2009/9/3/entrez PY - 2009/9/3/pubmed PY - 2009/9/24/medline SP - 642 EP - 8 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1171 N2 - A recent study reported on the efficacy of the EGFR inhibitor on locally advanced vulvar cancer. The aim of this study was to evaluate the effect of an EGFR tyrosine kinase inhibitor (AG1478) alone and in combination with cisplatin on vulvar cancer cells (A431 and SW962). We detected overexpression of EGFR in A431 cells and low expression in SW962 cells. We found that the growth inhibitory effect of AG1478 was dependent upon the expression level of EGFR. The combined treatment of AG1478 with cisplatin failed to exert any synergistic or additive effect in either cell line. In the EGFR signaling pathway, AG1478 decreased the phosphorylation of extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) in parallel with decreased activity of EGFR in A431 cells, while no changes in ERK and Akt were observed in SW962 cells. The combination of AG1478 with cisplatin completely inhibited the phosphorylation of ERK and Akt in A431 cells but not in SW962 cells. Cisplatin alone and its combination with AG1478 increased the phosphorylation of p38 and c-Jun N-terminal kinase (JNK) in both cell lines. In summary, AG1478 inhibited the growth activity of vulvar cancer cells, depending upon the expression level of EGFR, by inhibiting the activities of EGFR, Akt, and ERK. Given the absence of synergistic effects from the combination of AG1478 with cisplatin, combination therapy should be considered cautiously. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/19723115/Effect_of_epidermal_growth_factor_receptor_inhibitor_alone_and_in_combination_with_cisplatin_on_growth_of_vulvar_cancer_cells_ DB - PRIME DP - Unbound Medicine ER -