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Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine.
Cephalalgia 2009; 29 Suppl 2:1-6C

Abstract

Migraine is a neurovascular disorder characterized by recurrent episodic headaches, and is caused by abnormal processing of sensory information due to peripheral and/or central sensitization. The exact pathophysiological mechanism underlying migraine is not fully understood; however, cortical spreading depression (CSD) is thought to provide the basis for migraine aura and may serve as a trigger of migraine pain. CSD depends on neuronal-glial cell communication, which is mediated by intercellular transfer of messengers through connexin-containing gap junctions, as well as messengers released into the extracellular space by non-junctional connexin-containing hemichannels. These processes are believed to be important in peripheral sensitization within the trigeminal ganglion and to lead to central sensitization. The novel benzopyran compound tonabersat binds selectively to a unique site in the brain. In preclinical studies, tonabersat markedly reduced CSD and CSD-associated events and inhibited gap-junction communication between neurons and satellite glial cells in the trigeminal ganglion. Together, these findings suggest that tonabersat should have clinical application in preventing migraine attacks.

Authors+Show Affiliations

Center for Biomedical and Life Sciences, Missouri State University, Springfield, MO 65897, USA. pauldurham@missouristate.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19723120

Citation

Durham, P L., and F G. Garrett. "Neurological Mechanisms of Migraine: Potential of the Gap-junction Modulator Tonabersat in Prevention of Migraine." Cephalalgia : an International Journal of Headache, vol. 29 Suppl 2, 2009, pp. 1-6.
Durham PL, Garrett FG. Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine. Cephalalgia. 2009;29 Suppl 2:1-6.
Durham, P. L., & Garrett, F. G. (2009). Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine. Cephalalgia : an International Journal of Headache, 29 Suppl 2, pp. 1-6. doi:10.1111/j.1468-2982.2009.01976.x.
Durham PL, Garrett FG. Neurological Mechanisms of Migraine: Potential of the Gap-junction Modulator Tonabersat in Prevention of Migraine. Cephalalgia. 2009;29 Suppl 2:1-6. PubMed PMID: 19723120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine. AU - Durham,P L, AU - Garrett,F G, PY - 2009/9/3/entrez PY - 2009/9/3/pubmed PY - 2009/11/18/medline SP - 1 EP - 6 JF - Cephalalgia : an international journal of headache JO - Cephalalgia VL - 29 Suppl 2 N2 - Migraine is a neurovascular disorder characterized by recurrent episodic headaches, and is caused by abnormal processing of sensory information due to peripheral and/or central sensitization. The exact pathophysiological mechanism underlying migraine is not fully understood; however, cortical spreading depression (CSD) is thought to provide the basis for migraine aura and may serve as a trigger of migraine pain. CSD depends on neuronal-glial cell communication, which is mediated by intercellular transfer of messengers through connexin-containing gap junctions, as well as messengers released into the extracellular space by non-junctional connexin-containing hemichannels. These processes are believed to be important in peripheral sensitization within the trigeminal ganglion and to lead to central sensitization. The novel benzopyran compound tonabersat binds selectively to a unique site in the brain. In preclinical studies, tonabersat markedly reduced CSD and CSD-associated events and inhibited gap-junction communication between neurons and satellite glial cells in the trigeminal ganglion. Together, these findings suggest that tonabersat should have clinical application in preventing migraine attacks. SN - 1468-2982 UR - https://www.unboundmedicine.com/medline/citation/19723120/Neurological_mechanisms_of_migraine:_potential_of_the_gap_junction_modulator_tonabersat_in_prevention_of_migraine_ L2 - http://journals.sagepub.com/doi/full/10.1111/j.1468-2982.2009.01976.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -