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Coordinated expression of ER, PR and HER2 define different prognostic subtypes among poorly differentiated breast carcinomas.
Histopathology. 2009 Sep; 55(3):346-52.H

Abstract

AIMS

Histological grade is one of the most important prognostic factors in breast carcinomas, but poorly differentiated neoplasms still have quite heterogeneous biological behaviour, since they can be genetically classified as basal-like, HER2+ or even luminal. The aim was to analyse the frequency of oestrogen receptor (ER), progesterone receptor (PR) and HER2 expression profiles among breast carcinomas with <10% tubular formation, and their correlation with classic prognostic factors.

METHODS AND RESULTS

One hundred and thirty-four samples of paraffin-embedded tumours were studied retrospectively. The tumours were classified in to four groups by their ER/PR/HER2 profile: (i) ER+ and/or PR+ but HER2-; (ii) ER+ and/or PR+ and HER2+; (iii) ER- and/or PR- but HER2+; and (iv) ER-, PR- and HER2- (triple-negative). The histological features of triple-negative and HER2+ carcinomas overlap. The only difference was the expression of basal cytokeratins (basal CK), which was more frequent among triple-negative carcinomas. Basal-CK expression defined a more aggressive group of tumours, according to the pathological features, regardless of the immunohistochemical profile.

CONCLUSIONS

Group 1 and 2 tumours (ER+ and/or PR+ tumours with or without HER2 expression) were not statistically different, suggesting that poorly differentiated carcinomas with hormone receptors correspond to the luminal B type of tumour. Among poorly differentiated breast carcinomas, the classic profile associated with basal-CK identifies distinct subtypes equivalent to those seen by genetic classification.

Authors+Show Affiliations

Department of Pathology, Universidade de São Paulo, SP 01246-903, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19723150

Citation

Fernandes, Raquel C M., et al. "Coordinated Expression of ER, PR and HER2 Define Different Prognostic Subtypes Among Poorly Differentiated Breast Carcinomas." Histopathology, vol. 55, no. 3, 2009, pp. 346-52.
Fernandes RC, Bevilacqua JL, Soares IC, et al. Coordinated expression of ER, PR and HER2 define different prognostic subtypes among poorly differentiated breast carcinomas. Histopathology. 2009;55(3):346-52.
Fernandes, R. C., Bevilacqua, J. L., Soares, I. C., Siqueira, S. A., Pires, L., Hegg, R., & Carvalho, F. M. (2009). Coordinated expression of ER, PR and HER2 define different prognostic subtypes among poorly differentiated breast carcinomas. Histopathology, 55(3), 346-52. https://doi.org/10.1111/j.1365-2559.2009.03380.x
Fernandes RC, et al. Coordinated Expression of ER, PR and HER2 Define Different Prognostic Subtypes Among Poorly Differentiated Breast Carcinomas. Histopathology. 2009;55(3):346-52. PubMed PMID: 19723150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coordinated expression of ER, PR and HER2 define different prognostic subtypes among poorly differentiated breast carcinomas. AU - Fernandes,Raquel C M, AU - Bevilacqua,Jose L B, AU - Soares,Ibere C, AU - Siqueira,Sheila A C, AU - Pires,Luis, AU - Hegg,Roberto, AU - Carvalho,Filomena M, PY - 2009/9/3/entrez PY - 2009/9/3/pubmed PY - 2009/11/6/medline SP - 346 EP - 52 JF - Histopathology JO - Histopathology VL - 55 IS - 3 N2 - AIMS: Histological grade is one of the most important prognostic factors in breast carcinomas, but poorly differentiated neoplasms still have quite heterogeneous biological behaviour, since they can be genetically classified as basal-like, HER2+ or even luminal. The aim was to analyse the frequency of oestrogen receptor (ER), progesterone receptor (PR) and HER2 expression profiles among breast carcinomas with <10% tubular formation, and their correlation with classic prognostic factors. METHODS AND RESULTS: One hundred and thirty-four samples of paraffin-embedded tumours were studied retrospectively. The tumours were classified in to four groups by their ER/PR/HER2 profile: (i) ER+ and/or PR+ but HER2-; (ii) ER+ and/or PR+ and HER2+; (iii) ER- and/or PR- but HER2+; and (iv) ER-, PR- and HER2- (triple-negative). The histological features of triple-negative and HER2+ carcinomas overlap. The only difference was the expression of basal cytokeratins (basal CK), which was more frequent among triple-negative carcinomas. Basal-CK expression defined a more aggressive group of tumours, according to the pathological features, regardless of the immunohistochemical profile. CONCLUSIONS: Group 1 and 2 tumours (ER+ and/or PR+ tumours with or without HER2 expression) were not statistically different, suggesting that poorly differentiated carcinomas with hormone receptors correspond to the luminal B type of tumour. Among poorly differentiated breast carcinomas, the classic profile associated with basal-CK identifies distinct subtypes equivalent to those seen by genetic classification. SN - 1365-2559 UR - https://www.unboundmedicine.com/medline/citation/19723150/Coordinated_expression_of_ER_PR_and_HER2_define_different_prognostic_subtypes_among_poorly_differentiated_breast_carcinomas_ L2 - https://doi.org/10.1111/j.1365-2559.2009.03380.x DB - PRIME DP - Unbound Medicine ER -