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Protective effect of histamine H2 receptor antagonist ranitidine against rotenone-induced apoptosis.
Neurotoxicology. 2009 Nov; 30(6):1114-9.N

Abstract

Histamine H(2) receptor antagonists have been reported to improve the motor symptoms of Parkinson's disease (PD) patients and to exert neuroprotective effects. In this study, we investigated the protective effects of the H(2) receptor antagonist ranitidine on rotenone-induced apoptosis in human dopaminergic SH-SY5Y cells, focusing on mitogen-activated protein kinases (MAPKs) and caspases (CASPs)-mediated apoptotic events. Ranitidine blocked the rotenone-induced phosphorylation of c-Jun NH(2)-terminal protein kinase (JNK) and P38 MAPK (P38), and promoted the phosphorylation of extracellular signal-regulated protein kinase (ERK). Ranitidine also prevented the down-regulation of B-cell CLL/lymphoma 2 (BCL2) and the up-regulation of BCL2-associated X protein (BAX) by rotenone. Furthermore, ranitidine not only attenuated rotenone-induced cleavages of CASP9, poly(ADP-ribose) polymerase-1 (PARP) and CASP3, but also suppressed CASP3 enzyme activity. These results indicate that ranitidine protects against rotenone-induced apoptosis, inhibiting phosphorylation of JNK and P38, and activation of CASPs in human dopaminergic SH-SY5Y cells.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19723537

Citation

Park, Hae Jeong, et al. "Protective Effect of Histamine H2 Receptor Antagonist Ranitidine Against Rotenone-induced Apoptosis." Neurotoxicology, vol. 30, no. 6, 2009, pp. 1114-9.
Park HJ, Kim HJ, Park HK, et al. Protective effect of histamine H2 receptor antagonist ranitidine against rotenone-induced apoptosis. Neurotoxicology. 2009;30(6):1114-9.
Park, H. J., Kim, H. J., Park, H. K., & Chung, J. H. (2009). Protective effect of histamine H2 receptor antagonist ranitidine against rotenone-induced apoptosis. Neurotoxicology, 30(6), 1114-9. https://doi.org/10.1016/j.neuro.2009.08.005
Park HJ, et al. Protective Effect of Histamine H2 Receptor Antagonist Ranitidine Against Rotenone-induced Apoptosis. Neurotoxicology. 2009;30(6):1114-9. PubMed PMID: 19723537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of histamine H2 receptor antagonist ranitidine against rotenone-induced apoptosis. AU - Park,Hae Jeong, AU - Kim,Hak Jae, AU - Park,Hyun-Kyung, AU - Chung,Joo-Ho, Y1 - 2009/08/31/ PY - 2009/05/27/received PY - 2009/08/25/revised PY - 2009/08/25/accepted PY - 2009/9/3/entrez PY - 2009/9/3/pubmed PY - 2010/3/10/medline SP - 1114 EP - 9 JF - Neurotoxicology JO - Neurotoxicology VL - 30 IS - 6 N2 - Histamine H(2) receptor antagonists have been reported to improve the motor symptoms of Parkinson's disease (PD) patients and to exert neuroprotective effects. In this study, we investigated the protective effects of the H(2) receptor antagonist ranitidine on rotenone-induced apoptosis in human dopaminergic SH-SY5Y cells, focusing on mitogen-activated protein kinases (MAPKs) and caspases (CASPs)-mediated apoptotic events. Ranitidine blocked the rotenone-induced phosphorylation of c-Jun NH(2)-terminal protein kinase (JNK) and P38 MAPK (P38), and promoted the phosphorylation of extracellular signal-regulated protein kinase (ERK). Ranitidine also prevented the down-regulation of B-cell CLL/lymphoma 2 (BCL2) and the up-regulation of BCL2-associated X protein (BAX) by rotenone. Furthermore, ranitidine not only attenuated rotenone-induced cleavages of CASP9, poly(ADP-ribose) polymerase-1 (PARP) and CASP3, but also suppressed CASP3 enzyme activity. These results indicate that ranitidine protects against rotenone-induced apoptosis, inhibiting phosphorylation of JNK and P38, and activation of CASPs in human dopaminergic SH-SY5Y cells. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/19723537/Protective_effect_of_histamine_H2_receptor_antagonist_ranitidine_against_rotenone_induced_apoptosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(09)00177-6 DB - PRIME DP - Unbound Medicine ER -