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Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease.
Lancet. 1990 Jun 23; 335(8704):1487-90.Lct

Abstract

Intestinal humoral immunity was examined in eight patients with dermatitis herpetiformis and normal jejunal histology (as determined by quantitative morphometry) on a gluten-containing diet. Jejunal aspirate was taken at the time of jejunal biopsy, and levels of total immunoglobulins (IgA, IgM, IgG) and specific antibody to gliadin and two other dietary proteins, betalactoglobulin and ovalbumin, were measured. The pattern of secretory immune responses in the dermatitis herpetiformis patients was similar to that in twenty-six patients with untreated coeliac disease--ie, higher than normal concentrations of IgA, IgM, and IgG and high levels of specific antibodies (IgA and IgM) to the three dietary proteins. Serum levels of IgA antigliadin were similar in the dermatitis herpetiformis and control (twenty-eight patients who underwent jejunal biopsy to exclude coeliac disease) groups, and serum levels of IgG antigliadin were intermediate between those of the control and coeliac disease groups. These findings suggest that investigation of gut humoral immunity may provide a diagnostic index of latent coeliac disease. The definition of coeliac disease as a permanent gluten-sensitive enteropathy may have to be revised if the proposed two-stage model is confirmed.

Authors+Show Affiliations

Gastrointestinal Unit, University of Edinburgh, Western General Hospital, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1972433

Citation

O'Mahony, S, et al. "Similarities in Intestinal Humoral Immunity in Dermatitis Herpetiformis Without Enteropathy and in Coeliac Disease." Lancet (London, England), vol. 335, no. 8704, 1990, pp. 1487-90.
O'Mahony S, Vestey JP, Ferguson A. Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease. Lancet. 1990;335(8704):1487-90.
O'Mahony, S., Vestey, J. P., & Ferguson, A. (1990). Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease. Lancet (London, England), 335(8704), 1487-90.
O'Mahony S, Vestey JP, Ferguson A. Similarities in Intestinal Humoral Immunity in Dermatitis Herpetiformis Without Enteropathy and in Coeliac Disease. Lancet. 1990 Jun 23;335(8704):1487-90. PubMed PMID: 1972433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease. AU - O'Mahony,S, AU - Vestey,J P, AU - Ferguson,A, PY - 1990/6/23/pubmed PY - 1990/6/23/medline PY - 1990/6/23/entrez SP - 1487 EP - 90 JF - Lancet (London, England) JO - Lancet VL - 335 IS - 8704 N2 - Intestinal humoral immunity was examined in eight patients with dermatitis herpetiformis and normal jejunal histology (as determined by quantitative morphometry) on a gluten-containing diet. Jejunal aspirate was taken at the time of jejunal biopsy, and levels of total immunoglobulins (IgA, IgM, IgG) and specific antibody to gliadin and two other dietary proteins, betalactoglobulin and ovalbumin, were measured. The pattern of secretory immune responses in the dermatitis herpetiformis patients was similar to that in twenty-six patients with untreated coeliac disease--ie, higher than normal concentrations of IgA, IgM, and IgG and high levels of specific antibodies (IgA and IgM) to the three dietary proteins. Serum levels of IgA antigliadin were similar in the dermatitis herpetiformis and control (twenty-eight patients who underwent jejunal biopsy to exclude coeliac disease) groups, and serum levels of IgG antigliadin were intermediate between those of the control and coeliac disease groups. These findings suggest that investigation of gut humoral immunity may provide a diagnostic index of latent coeliac disease. The definition of coeliac disease as a permanent gluten-sensitive enteropathy may have to be revised if the proposed two-stage model is confirmed. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/1972433/Similarities_in_intestinal_humoral_immunity_in_dermatitis_herpetiformis_without_enteropathy_and_in_coeliac_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0140-6736(90)93029-O DB - PRIME DP - Unbound Medicine ER -