Tags

Type your tag names separated by a space and hit enter

[Effects of pravastatin and granulocyto-colony stimulating factor in mobilizing endothelial progenitor cells in mice with myocardial ischemia].
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Aug; 29(8):1660-2.NF

Abstract

OBJECTIVE

To compare the effects of pravastatin and granulocyto-colony stimulating factor (G-CSF) in mobilizing endothelial progenitor cells (EPCs) in mice with myocardial ischemia, and explore the possible mechanism of EPC mobilization.

METHODS

Ninety-six mice were randomly divided into 4 groups (n=24), namely the control group, saline group, pravastatin group and G-CSF group. In the latter 3 groups, myocardial ischemia was induced with isoprenine followed by intraperitoneal injections of normal saline, pravastatin and G-CSF for 5 consecutive days. On days 1, 5, 7, and 9 after establishment of myocardial ischemia, 6 mice from each group were randomly selected for measurement of the EPC count and serum concentrations of vascular endothelial growth factor (VEGF).

RESULTS

Compared with the control group, EPC count increased slightly in the saline group on days 1, 5, and 7. EPC count increased significantly in pravastatin group on days 5, 7 and 9 in comparison with that of the saline group, and the increment was more obvious in G-CSF group. In comparison with the control group, the concentrations of VEGF augmented on days 5, 7 and 9 in the order of saline group, pravastatin group and G-CSF group. The effect of G-CSF on EPC mobilization was positively correlated to VEGF concentrations.

CONCLUSION

Myocardial ischemia induces EPC mobilization and VEGF release. Both Pravastatin and G-CSF can enhance EPC mobilization from the bone marrow and VEGF release, but G-CSF produces a stronger effect on EPC mobilization in association of VEGF release.

Authors+Show Affiliations

Department of Cardiovascular Surgery, General Hospital of PLA, Beijing 100853, China. chentt301 @263.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19726323

Citation

Chen, Ting-ting, et al. "[Effects of Pravastatin and Granulocyto-colony Stimulating Factor in Mobilizing Endothelial Progenitor Cells in Mice With Myocardial Ischemia]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 29, no. 8, 2009, pp. 1660-2.
Chen TT, Mi WD, Wang G, et al. [Effects of pravastatin and granulocyto-colony stimulating factor in mobilizing endothelial progenitor cells in mice with myocardial ischemia]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29(8):1660-2.
Chen, T. T., Mi, W. D., Wang, G., Li, L. B., & Gao, C. Q. (2009). [Effects of pravastatin and granulocyto-colony stimulating factor in mobilizing endothelial progenitor cells in mice with myocardial ischemia]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 29(8), 1660-2.
Chen TT, et al. [Effects of Pravastatin and Granulocyto-colony Stimulating Factor in Mobilizing Endothelial Progenitor Cells in Mice With Myocardial Ischemia]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29(8):1660-2. PubMed PMID: 19726323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of pravastatin and granulocyto-colony stimulating factor in mobilizing endothelial progenitor cells in mice with myocardial ischemia]. AU - Chen,Ting-ting, AU - Mi,Wei-dong, AU - Wang,Gang, AU - Li,Li-bing, AU - Gao,Chang-qing, PY - 2009/9/4/entrez PY - 2009/9/4/pubmed PY - 2010/1/7/medline SP - 1660 EP - 2 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 29 IS - 8 N2 - OBJECTIVE: To compare the effects of pravastatin and granulocyto-colony stimulating factor (G-CSF) in mobilizing endothelial progenitor cells (EPCs) in mice with myocardial ischemia, and explore the possible mechanism of EPC mobilization. METHODS: Ninety-six mice were randomly divided into 4 groups (n=24), namely the control group, saline group, pravastatin group and G-CSF group. In the latter 3 groups, myocardial ischemia was induced with isoprenine followed by intraperitoneal injections of normal saline, pravastatin and G-CSF for 5 consecutive days. On days 1, 5, 7, and 9 after establishment of myocardial ischemia, 6 mice from each group were randomly selected for measurement of the EPC count and serum concentrations of vascular endothelial growth factor (VEGF). RESULTS: Compared with the control group, EPC count increased slightly in the saline group on days 1, 5, and 7. EPC count increased significantly in pravastatin group on days 5, 7 and 9 in comparison with that of the saline group, and the increment was more obvious in G-CSF group. In comparison with the control group, the concentrations of VEGF augmented on days 5, 7 and 9 in the order of saline group, pravastatin group and G-CSF group. The effect of G-CSF on EPC mobilization was positively correlated to VEGF concentrations. CONCLUSION: Myocardial ischemia induces EPC mobilization and VEGF release. Both Pravastatin and G-CSF can enhance EPC mobilization from the bone marrow and VEGF release, but G-CSF produces a stronger effect on EPC mobilization in association of VEGF release. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/19726323/[Effects_of_pravastatin_and_granulocyto_colony_stimulating_factor_in_mobilizing_endothelial_progenitor_cells_in_mice_with_myocardial_ischemia]_ L2 - https://medlineplus.gov/stemcells.html DB - PRIME DP - Unbound Medicine ER -