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Iodine supplementation improves cognition in mildly iodine-deficient children.
Am J Clin Nutr. 2009 Nov; 90(5):1264-71.AJ

Abstract

BACKGROUND

The effects of severe iodine deficiency during critical periods of brain development are well documented. There is little known about the consequences of milder forms of iodine deficiency on neurodevelopment.

OBJECTIVE

The objective was to determine whether supplementing mildly iodine-deficient children with iodine improves cognition.

DESIGN

A randomized, placebo-controlled, double-blind trial was conducted in 184 children aged 10-13 y in Dunedin, New Zealand. Children were randomly assigned to receive a daily tablet containing either 150 microg I or placebo for 28 wk. Biochemical, anthropometric, and dietary data were collected from each child at baseline and after 28 wk. Cognitive performance was assessed through 4 subtests from the Wechsler Intelligence Scale for Children.

RESULTS

At baseline, children were mildly iodine deficient [median urinary iodine concentration (UIC): 63 microg/L; thyroglobulin concentration: 16.4 microg/L]. After 28 wk, iodine status improved in the supplemented group (UIC: 145 microg/L; thyroglobulin: 8.5 microg/L), whereas the placebo group remained iodine deficient (UIC: 81 microg/L; thyroglobulin: 11.6 microg/L). Iodine supplementation significantly improved scores for 2 of the 4 cognitive subtests [picture concepts (P = 0.023) and matrix reasoning (P = 0.040)] but not for letter-number sequencing (P = 0.480) or symbol search (P = 0.608). The overall cognitive score of the iodine-supplemented group was 0.19 SDs higher than that of the placebo group (P = 0.011).

CONCLUSIONS

Iodine supplementation improved perceptual reasoning in mildly iodine-deficient children and suggests that mild iodine deficiency could prevent children from attaining their full intellectual potential. The trial was registered with the Australia New Zealand Clinical Trials Register as ACTRN12608000222347.

Authors+Show Affiliations

Department of Human Nutrition, University of Otago, Dunedin, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19726593

Citation

Gordon, Rosie C., et al. "Iodine Supplementation Improves Cognition in Mildly Iodine-deficient Children." The American Journal of Clinical Nutrition, vol. 90, no. 5, 2009, pp. 1264-71.
Gordon RC, Rose MC, Skeaff SA, et al. Iodine supplementation improves cognition in mildly iodine-deficient children. Am J Clin Nutr. 2009;90(5):1264-71.
Gordon, R. C., Rose, M. C., Skeaff, S. A., Gray, A. R., Morgan, K. M., & Ruffman, T. (2009). Iodine supplementation improves cognition in mildly iodine-deficient children. The American Journal of Clinical Nutrition, 90(5), 1264-71. https://doi.org/10.3945/ajcn.2009.28145
Gordon RC, et al. Iodine Supplementation Improves Cognition in Mildly Iodine-deficient Children. Am J Clin Nutr. 2009;90(5):1264-71. PubMed PMID: 19726593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iodine supplementation improves cognition in mildly iodine-deficient children. AU - Gordon,Rosie C, AU - Rose,Meredith C, AU - Skeaff,Sheila A, AU - Gray,Andrew R, AU - Morgan,Kirstie M D, AU - Ruffman,Ted, Y1 - 2009/09/02/ PY - 2009/9/4/entrez PY - 2009/9/4/pubmed PY - 2010/1/7/medline SP - 1264 EP - 71 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 90 IS - 5 N2 - BACKGROUND: The effects of severe iodine deficiency during critical periods of brain development are well documented. There is little known about the consequences of milder forms of iodine deficiency on neurodevelopment. OBJECTIVE: The objective was to determine whether supplementing mildly iodine-deficient children with iodine improves cognition. DESIGN: A randomized, placebo-controlled, double-blind trial was conducted in 184 children aged 10-13 y in Dunedin, New Zealand. Children were randomly assigned to receive a daily tablet containing either 150 microg I or placebo for 28 wk. Biochemical, anthropometric, and dietary data were collected from each child at baseline and after 28 wk. Cognitive performance was assessed through 4 subtests from the Wechsler Intelligence Scale for Children. RESULTS: At baseline, children were mildly iodine deficient [median urinary iodine concentration (UIC): 63 microg/L; thyroglobulin concentration: 16.4 microg/L]. After 28 wk, iodine status improved in the supplemented group (UIC: 145 microg/L; thyroglobulin: 8.5 microg/L), whereas the placebo group remained iodine deficient (UIC: 81 microg/L; thyroglobulin: 11.6 microg/L). Iodine supplementation significantly improved scores for 2 of the 4 cognitive subtests [picture concepts (P = 0.023) and matrix reasoning (P = 0.040)] but not for letter-number sequencing (P = 0.480) or symbol search (P = 0.608). The overall cognitive score of the iodine-supplemented group was 0.19 SDs higher than that of the placebo group (P = 0.011). CONCLUSIONS: Iodine supplementation improved perceptual reasoning in mildly iodine-deficient children and suggests that mild iodine deficiency could prevent children from attaining their full intellectual potential. The trial was registered with the Australia New Zealand Clinical Trials Register as ACTRN12608000222347. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19726593/Iodine_supplementation_improves_cognition_in_mildly_iodine_deficient_children_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28145 DB - PRIME DP - Unbound Medicine ER -