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Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs.
J Neurophysiol. 2009 Dec; 102(6):3180-90.JN

Abstract

Transcranial stimulation techniques have revealed homeostatic-like metaplasticity in the hand area of the human primary motor cortex (M1(HAND)) that controls stimulation-induced changes in corticospinal excitability. Here we combined two interventional protocols that induce long-term depression (LTD)-like or long-term potentiation (LTP)-like plasticity in left M1(HAND) through different afferents. We hypothesized that the left M1(HAND) would integrate LTP- and LTD-like plasticity in a homeostatic fashion. In ten healthy volunteers, low-intensity repetitive transcranial magnetic stimulation (rTMS) of the left dorsal premotor cortex (PMD) was first applied to produce an LTP-like increase (5 Hz rTMS) or LTD-like decrease (1 Hz rTMS) in corticospinal excitability in left M1(HAND) via premotor-to-motor inputs. Following PMD rTMS, paired-associative stimulation (PAS) was applied to the right median nerve and left M1(HAND) to induce spike-time-dependent plasticity in sensory-to-motor inputs to left M1(HAND). We adjusted the interstimulus interval to the N20 latency of the median nerve somatosensory-evoked cortical potential to produce an LTP-like increase (PAS(N20+2ms)) or an LTD-like decrease (PAS(N20-5ms)) in corticospinal excitability. The amplitude of motor-evoked potentials was recorded from intrinsic hand muscles to assess stimulation-induced changes in corticospinal excitability. Premotor-to-motor preconditioning triggered a homeostatic response to subsequent sensory-to-motor PAS. After facilitatory 5 Hz rTMS, "facilitatory" PAS(N20+2ms) suppressed corticospinal excitability. Likewise, "inhibitory" PAS(N20-5ms) facilitated corticospinal excitability after "inhibitory" 1 Hz rTMS. There was a negative linear relationship between the excitability changes induced by PMD rTMS and those elicited by subsequent PAS. Excitability changes were not paralleled by changes in performance during a finger-tapping task. These results provide evidence for a homeostatic response pattern in the human M1(HAND) that integrates acute plastic changes evoked through different "input channels."

Authors+Show Affiliations

Department of Neurology, Christian-Albrechts-University, Kiel, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19726723

Citation

Pötter-Nerger, Monika, et al. "Inducing Homeostatic-like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs." Journal of Neurophysiology, vol. 102, no. 6, 2009, pp. 3180-90.
Pötter-Nerger M, Fischer S, Mastroeni C, et al. Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs. J Neurophysiol. 2009;102(6):3180-90.
Pötter-Nerger, M., Fischer, S., Mastroeni, C., Groppa, S., Deuschl, G., Volkmann, J., Quartarone, A., Münchau, A., & Siebner, H. R. (2009). Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs. Journal of Neurophysiology, 102(6), 3180-90. https://doi.org/10.1152/jn.91046.2008
Pötter-Nerger M, et al. Inducing Homeostatic-like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs. J Neurophysiol. 2009;102(6):3180-90. PubMed PMID: 19726723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs. AU - Pötter-Nerger,Monika, AU - Fischer,Sarah, AU - Mastroeni,Claudia, AU - Groppa,Sergiu, AU - Deuschl,Günther, AU - Volkmann,Jens, AU - Quartarone,Angelo, AU - Münchau,Alexander, AU - Siebner,Hartwig Roman, Y1 - 2009/09/02/ PY - 2009/9/4/entrez PY - 2009/9/4/pubmed PY - 2010/2/23/medline SP - 3180 EP - 90 JF - Journal of neurophysiology JO - J. Neurophysiol. VL - 102 IS - 6 N2 - Transcranial stimulation techniques have revealed homeostatic-like metaplasticity in the hand area of the human primary motor cortex (M1(HAND)) that controls stimulation-induced changes in corticospinal excitability. Here we combined two interventional protocols that induce long-term depression (LTD)-like or long-term potentiation (LTP)-like plasticity in left M1(HAND) through different afferents. We hypothesized that the left M1(HAND) would integrate LTP- and LTD-like plasticity in a homeostatic fashion. In ten healthy volunteers, low-intensity repetitive transcranial magnetic stimulation (rTMS) of the left dorsal premotor cortex (PMD) was first applied to produce an LTP-like increase (5 Hz rTMS) or LTD-like decrease (1 Hz rTMS) in corticospinal excitability in left M1(HAND) via premotor-to-motor inputs. Following PMD rTMS, paired-associative stimulation (PAS) was applied to the right median nerve and left M1(HAND) to induce spike-time-dependent plasticity in sensory-to-motor inputs to left M1(HAND). We adjusted the interstimulus interval to the N20 latency of the median nerve somatosensory-evoked cortical potential to produce an LTP-like increase (PAS(N20+2ms)) or an LTD-like decrease (PAS(N20-5ms)) in corticospinal excitability. The amplitude of motor-evoked potentials was recorded from intrinsic hand muscles to assess stimulation-induced changes in corticospinal excitability. Premotor-to-motor preconditioning triggered a homeostatic response to subsequent sensory-to-motor PAS. After facilitatory 5 Hz rTMS, "facilitatory" PAS(N20+2ms) suppressed corticospinal excitability. Likewise, "inhibitory" PAS(N20-5ms) facilitated corticospinal excitability after "inhibitory" 1 Hz rTMS. There was a negative linear relationship between the excitability changes induced by PMD rTMS and those elicited by subsequent PAS. Excitability changes were not paralleled by changes in performance during a finger-tapping task. These results provide evidence for a homeostatic response pattern in the human M1(HAND) that integrates acute plastic changes evoked through different "input channels." SN - 1522-1598 UR - https://www.unboundmedicine.com/medline/citation/19726723/Inducing_homeostatic_like_plasticity_in_human_motor_cortex_through_converging_corticocortical_inputs_ L2 - http://www.physiology.org/doi/full/10.1152/jn.91046.2008?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -