Tags

Type your tag names separated by a space and hit enter

One year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine D1 and D2 receptor agonists.
J Pharmacol Exp Ther. 1990 Jun; 253(3):1198-205.JP

Abstract

In a "blind" experimental design, the sensitivity of caudate-putamen (CPu) cells to the selective dopamine (DA) D1 receptor agonist SKF-38393 and D2 receptor agonist LY171555 (quinpirole) in rats treated with either haloperidol (HAL), clozapine or tap water for 1 year was compared using the techniques of single cell recording and microiontophoresis. Although the maximum binding value for D2 receptors was elevated in chronic HAL-treated rats, there was no sign of electrophysiological supersensitivity of CPu neurons to the selective DA D1 and D2 receptor agonists. CPu cells were subsensitive to LY-171555 in HAL-treated rats without a drug withdrawal period. This suggests that residual HAL in the rat brain actively blocked the D2 DA receptors. In contrast, in clozapine-treated rats with or without a drug withdrawal period, the sensitivity of CPu cells to either the D1 or D2 agonists was not altered. Coadministration of SKF-38393 and LY-171555 onto the CPu neurons primarily produced an additive effect and only two cells both from the HAL group showed a synergistic action. The majority of CPu cells failed to respond to iontophoretic application of CCK-8S in either the control or antipsychotic drug-treated rats. If these findings can be extended to humans, they do not support the view that tardive dyskinesia is the result of CPu DA receptor supersensitivity.

Authors+Show Affiliations

Department of Psychiatry and Behavioral Sciences, State University of New York, Stony Brook.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1972751

Citation

Jiang, L H., et al. "One Year of Continuous Treatment With Haloperidol or Clozapine Fails to Induce a Hypersensitive Response of Caudate Putamen Neurons to Dopamine D1 and D2 Receptor Agonists." The Journal of Pharmacology and Experimental Therapeutics, vol. 253, no. 3, 1990, pp. 1198-205.
Jiang LH, Kasser RJ, Altar CA, et al. One year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine D1 and D2 receptor agonists. J Pharmacol Exp Ther. 1990;253(3):1198-205.
Jiang, L. H., Kasser, R. J., Altar, C. A., & Wang, R. Y. (1990). One year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine D1 and D2 receptor agonists. The Journal of Pharmacology and Experimental Therapeutics, 253(3), 1198-205.
Jiang LH, et al. One Year of Continuous Treatment With Haloperidol or Clozapine Fails to Induce a Hypersensitive Response of Caudate Putamen Neurons to Dopamine D1 and D2 Receptor Agonists. J Pharmacol Exp Ther. 1990;253(3):1198-205. PubMed PMID: 1972751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine D1 and D2 receptor agonists. AU - Jiang,L H, AU - Kasser,R J, AU - Altar,C A, AU - Wang,R Y, PY - 1990/6/1/pubmed PY - 1990/6/1/medline PY - 1990/6/1/entrez SP - 1198 EP - 205 JF - The Journal of pharmacology and experimental therapeutics JO - J. Pharmacol. Exp. Ther. VL - 253 IS - 3 N2 - In a "blind" experimental design, the sensitivity of caudate-putamen (CPu) cells to the selective dopamine (DA) D1 receptor agonist SKF-38393 and D2 receptor agonist LY171555 (quinpirole) in rats treated with either haloperidol (HAL), clozapine or tap water for 1 year was compared using the techniques of single cell recording and microiontophoresis. Although the maximum binding value for D2 receptors was elevated in chronic HAL-treated rats, there was no sign of electrophysiological supersensitivity of CPu neurons to the selective DA D1 and D2 receptor agonists. CPu cells were subsensitive to LY-171555 in HAL-treated rats without a drug withdrawal period. This suggests that residual HAL in the rat brain actively blocked the D2 DA receptors. In contrast, in clozapine-treated rats with or without a drug withdrawal period, the sensitivity of CPu cells to either the D1 or D2 agonists was not altered. Coadministration of SKF-38393 and LY-171555 onto the CPu neurons primarily produced an additive effect and only two cells both from the HAL group showed a synergistic action. The majority of CPu cells failed to respond to iontophoretic application of CCK-8S in either the control or antipsychotic drug-treated rats. If these findings can be extended to humans, they do not support the view that tardive dyskinesia is the result of CPu DA receptor supersensitivity. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/1972751/One_year_of_continuous_treatment_with_haloperidol_or_clozapine_fails_to_induce_a_hypersensitive_response_of_caudate_putamen_neurons_to_dopamine_D1_and_D2_receptor_agonists_ L2 - http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=1972751 DB - PRIME DP - Unbound Medicine ER -