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Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4(+)CD25(+)Foxp3(+) Treg in mice.
Eur J Immunol 2009; 39(10):2822-30EJ

Abstract

Malaria and intestinal nematode infection are widespread and co-infection frequently occurs. We investigated whether co-infected intestinal nematodes modulate immunity against co-existing malaria parasites. Infection of C57BL/6 mice with Plasmodium yoelii 17XNL (Py) was transient and self-limiting, but preceding infection with Heligmosomoides polygyrus (Hp), a mouse intestinal nematode, exacerbated malaria resulting in higher parasite burdens and poor survival of the mice. Co-infection with Hp led to reduced Py-responsive proliferation and IFN-gamma production of spleen cells, and higher activation of CD4(+)CD25(+)Foxp3(+) Treg. In vivo depletion of Treg recovered anti-Py immunity and rescued co-infected mice from exacerbated malaria. However, we did not observe any obvious ex vivo activation of Treg by either Hp products or living worms. Our results suggest that intestinal nematodes moderate host immune responses during acute malaria infection by aggressive activation of Treg. Elucidation of the mechanisms of Treg activation in situ is a target for future analyses.

Authors+Show Affiliations

Department of Parasitology, Kyushu University Graduate School of Medical Science, Fukuoka 812-0054, Japan. tetztani@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19728313

Citation

Tetsutani, Kohhei, et al. "Concurrent Infection With Heligmosomoides Polygyrus Suppresses anti-Plasmodium Yoelii Protection Partially By Induction of CD4(+)CD25(+)Foxp3(+) Treg in Mice." European Journal of Immunology, vol. 39, no. 10, 2009, pp. 2822-30.
Tetsutani K, Ishiwata K, Ishida H, et al. Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4(+)CD25(+)Foxp3(+) Treg in mice. Eur J Immunol. 2009;39(10):2822-30.
Tetsutani, K., Ishiwata, K., Ishida, H., Tu, L., Torii, M., Hamano, S., ... Hisaeda, H. (2009). Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4(+)CD25(+)Foxp3(+) Treg in mice. European Journal of Immunology, 39(10), pp. 2822-30. doi:10.1002/eji.200939433.
Tetsutani K, et al. Concurrent Infection With Heligmosomoides Polygyrus Suppresses anti-Plasmodium Yoelii Protection Partially By Induction of CD4(+)CD25(+)Foxp3(+) Treg in Mice. Eur J Immunol. 2009;39(10):2822-30. PubMed PMID: 19728313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4(+)CD25(+)Foxp3(+) Treg in mice. AU - Tetsutani,Kohhei, AU - Ishiwata,Kenji, AU - Ishida,Hidekazu, AU - Tu,Liping, AU - Torii,Motomi, AU - Hamano,Shinjiro, AU - Himeno,Kunisuke, AU - Hisaeda,Hajime, PY - 2009/9/4/entrez PY - 2009/9/4/pubmed PY - 2009/11/17/medline SP - 2822 EP - 30 JF - European journal of immunology JO - Eur. J. Immunol. VL - 39 IS - 10 N2 - Malaria and intestinal nematode infection are widespread and co-infection frequently occurs. We investigated whether co-infected intestinal nematodes modulate immunity against co-existing malaria parasites. Infection of C57BL/6 mice with Plasmodium yoelii 17XNL (Py) was transient and self-limiting, but preceding infection with Heligmosomoides polygyrus (Hp), a mouse intestinal nematode, exacerbated malaria resulting in higher parasite burdens and poor survival of the mice. Co-infection with Hp led to reduced Py-responsive proliferation and IFN-gamma production of spleen cells, and higher activation of CD4(+)CD25(+)Foxp3(+) Treg. In vivo depletion of Treg recovered anti-Py immunity and rescued co-infected mice from exacerbated malaria. However, we did not observe any obvious ex vivo activation of Treg by either Hp products or living worms. Our results suggest that intestinal nematodes moderate host immune responses during acute malaria infection by aggressive activation of Treg. Elucidation of the mechanisms of Treg activation in situ is a target for future analyses. SN - 1521-4141 UR - https://www.unboundmedicine.com/medline/citation/19728313/Concurrent_infection_with_Heligmosomoides_polygyrus_suppresses_anti_Plasmodium_yoelii_protection_partially_by_induction_of_CD4_+_CD25_+_Foxp3_+__Treg_in_mice_ L2 - https://doi.org/10.1002/eji.200939433 DB - PRIME DP - Unbound Medicine ER -