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Effects of alpha- and beta-adrenergic agonists and antagonists on growth hormone secretion in man.
Endocrinol Exp. 1990 Mar; 24(1-2):211-9.EE

Abstract

The adrenergic system is involved in the neural control of GH secretion with both stimulatory and inhibitory influences mainly mediated via GHRH and/or somatostatin modulation. To throw further light on adrenergic neuroregulation of somatotrophic function in man, the effect of various catecholamine agonists and antagonists on basal or GHRH-stimulated GH secretion was studied. Twenty-one adult males aged 20-30 years underwent the following studies: 1. clonidine (CLON), alpha 2-agonist, (15 micrograms/min infused i.v. from 0 to +10 min) alone and preceded by yohimbine (YOH), alpha 2-antagonist, (30 mg orally at -50 min); 2. GHRH (GHRH 44, 1 microgram/kg i.v. bolus at 0 min) alone and preceded by YOH; 3. CLON alone and combined with methoxamine (METHOX), alpha 1-agonist, (1 mg/min infused i.v. from -10 to +10 min); 4. GHRH alone and combined with i.v. infusion of phentolamine (PHEN), alpha 1/alpha 2-antagonist, (0.5 mg/min from -60 to +30 min); 5. GHRH alone and combined with i.v. infusion of salbutamol (SAL), beta 2-agonist, (10 micrograms/min from -5 to +15 min). The GH response to CLON was inhibited by YOH (area under the response curve, mean +/- S.E.: 672.6 +/- 143.0 vs. 219.6 +/- 16.7 micrograms/l/h, P less than 0.05) but was not modified by METHOX (278.4 +/- 94.1 vs. 216.7 +/- 115.5 micrograms/l/h). On the other hand, YOH was unable to affect the GH response to GHRH (339.3 +/- 19.1 vs. 518 +/- 172.8 micrograms/l/h).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Biomedicine, University of Turin, Hospital Molinette, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1972919

Citation

Mazza, E, et al. "Effects of Alpha- and Beta-adrenergic Agonists and Antagonists On Growth Hormone Secretion in Man." Endocrinologia Experimentalis, vol. 24, no. 1-2, 1990, pp. 211-9.
Mazza E, Ghigo E, Bellone J, et al. Effects of alpha- and beta-adrenergic agonists and antagonists on growth hormone secretion in man. Endocrinol Exp. 1990;24(1-2):211-9.
Mazza, E., Ghigo, E., Bellone, J., Arvat, E., Revelli, E., Cella, S. G., Brambilla, F., Müller, E. E., & Camanni, F. (1990). Effects of alpha- and beta-adrenergic agonists and antagonists on growth hormone secretion in man. Endocrinologia Experimentalis, 24(1-2), 211-9.
Mazza E, et al. Effects of Alpha- and Beta-adrenergic Agonists and Antagonists On Growth Hormone Secretion in Man. Endocrinol Exp. 1990;24(1-2):211-9. PubMed PMID: 1972919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of alpha- and beta-adrenergic agonists and antagonists on growth hormone secretion in man. AU - Mazza,E, AU - Ghigo,E, AU - Bellone,J, AU - Arvat,E, AU - Revelli,E, AU - Cella,S G, AU - Brambilla,F, AU - Müller,E E, AU - Camanni,F, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 211 EP - 9 JF - Endocrinologia experimentalis JO - Endocrinol. Exp. VL - 24 IS - 1-2 N2 - The adrenergic system is involved in the neural control of GH secretion with both stimulatory and inhibitory influences mainly mediated via GHRH and/or somatostatin modulation. To throw further light on adrenergic neuroregulation of somatotrophic function in man, the effect of various catecholamine agonists and antagonists on basal or GHRH-stimulated GH secretion was studied. Twenty-one adult males aged 20-30 years underwent the following studies: 1. clonidine (CLON), alpha 2-agonist, (15 micrograms/min infused i.v. from 0 to +10 min) alone and preceded by yohimbine (YOH), alpha 2-antagonist, (30 mg orally at -50 min); 2. GHRH (GHRH 44, 1 microgram/kg i.v. bolus at 0 min) alone and preceded by YOH; 3. CLON alone and combined with methoxamine (METHOX), alpha 1-agonist, (1 mg/min infused i.v. from -10 to +10 min); 4. GHRH alone and combined with i.v. infusion of phentolamine (PHEN), alpha 1/alpha 2-antagonist, (0.5 mg/min from -60 to +30 min); 5. GHRH alone and combined with i.v. infusion of salbutamol (SAL), beta 2-agonist, (10 micrograms/min from -5 to +15 min). The GH response to CLON was inhibited by YOH (area under the response curve, mean +/- S.E.: 672.6 +/- 143.0 vs. 219.6 +/- 16.7 micrograms/l/h, P less than 0.05) but was not modified by METHOX (278.4 +/- 94.1 vs. 216.7 +/- 115.5 micrograms/l/h). On the other hand, YOH was unable to affect the GH response to GHRH (339.3 +/- 19.1 vs. 518 +/- 172.8 micrograms/l/h).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0013-7200 UR - https://www.unboundmedicine.com/medline/citation/1972919/Effects_of_alpha__and_beta_adrenergic_agonists_and_antagonists_on_growth_hormone_secretion_in_man_ DB - PRIME DP - Unbound Medicine ER -