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Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
Trends Pharmacol Sci 2009; 30(10):515-27TP

Abstract

Delta(9)-tetrahydrocannabinol binds cannabinoid (CB(1) and CB(2)) receptors, which are activated by endogenous compounds (endocannabinoids) and are involved in a wide range of physiopathological processes (e.g. modulation of neurotransmitter release, regulation of pain perception, and of cardiovascular, gastrointestinal and liver functions). The well-known psychotropic effects of Delta(9)-tetrahydrocannabinol, which are mediated by activation of brain CB(1) receptors, have greatly limited its clinical use. However, the plant Cannabis contains many cannabinoids with weak or no psychoactivity that, therapeutically, might be more promising than Delta(9)-tetrahydrocannabinol. Here, we provide an overview of the recent pharmacological advances, novel mechanisms of action, and potential therapeutic applications of such non-psychotropic plant-derived cannabinoids. Special emphasis is given to cannabidiol, the possible applications of which have recently emerged in inflammation, diabetes, cancer, affective and neurodegenerative diseases, and to Delta(9)-tetrahydrocannabivarin, a novel CB(1) antagonist which exerts potentially useful actions in the treatment of epilepsy and obesity.

Authors+Show Affiliations

Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy. aaizzo@unina.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19729208

Citation

Izzo, Angelo A., et al. "Non-psychotropic Plant Cannabinoids: New Therapeutic Opportunities From an Ancient Herb." Trends in Pharmacological Sciences, vol. 30, no. 10, 2009, pp. 515-27.
Izzo AA, Borrelli F, Capasso R, et al. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci. 2009;30(10):515-27.
Izzo, A. A., Borrelli, F., Capasso, R., Di Marzo, V., & Mechoulam, R. (2009). Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends in Pharmacological Sciences, 30(10), pp. 515-27. doi:10.1016/j.tips.2009.07.006.
Izzo AA, et al. Non-psychotropic Plant Cannabinoids: New Therapeutic Opportunities From an Ancient Herb. Trends Pharmacol Sci. 2009;30(10):515-27. PubMed PMID: 19729208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. AU - Izzo,Angelo A, AU - Borrelli,Francesca, AU - Capasso,Raffaele, AU - Di Marzo,Vincenzo, AU - Mechoulam,Raphael, Y1 - 2009/09/02/ PY - 2009/05/20/received PY - 2009/07/09/revised PY - 2009/07/13/accepted PY - 2009/9/5/entrez PY - 2009/9/5/pubmed PY - 2009/12/16/medline SP - 515 EP - 27 JF - Trends in pharmacological sciences JO - Trends Pharmacol. Sci. VL - 30 IS - 10 N2 - Delta(9)-tetrahydrocannabinol binds cannabinoid (CB(1) and CB(2)) receptors, which are activated by endogenous compounds (endocannabinoids) and are involved in a wide range of physiopathological processes (e.g. modulation of neurotransmitter release, regulation of pain perception, and of cardiovascular, gastrointestinal and liver functions). The well-known psychotropic effects of Delta(9)-tetrahydrocannabinol, which are mediated by activation of brain CB(1) receptors, have greatly limited its clinical use. However, the plant Cannabis contains many cannabinoids with weak or no psychoactivity that, therapeutically, might be more promising than Delta(9)-tetrahydrocannabinol. Here, we provide an overview of the recent pharmacological advances, novel mechanisms of action, and potential therapeutic applications of such non-psychotropic plant-derived cannabinoids. Special emphasis is given to cannabidiol, the possible applications of which have recently emerged in inflammation, diabetes, cancer, affective and neurodegenerative diseases, and to Delta(9)-tetrahydrocannabivarin, a novel CB(1) antagonist which exerts potentially useful actions in the treatment of epilepsy and obesity. SN - 1873-3735 UR - https://www.unboundmedicine.com/medline/citation/19729208/Non_psychotropic_plant_cannabinoids:_new_therapeutic_opportunities_from_an_ancient_herb_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-6147(09)00128-X DB - PRIME DP - Unbound Medicine ER -