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Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.

Abstract

Delta(9)-tetrahydrocannabinol binds cannabinoid (CB(1) and CB(2)) receptors, which are activated by endogenous compounds (endocannabinoids) and are involved in a wide range of physiopathological processes (e.g. modulation of neurotransmitter release, regulation of pain perception, and of cardiovascular, gastrointestinal and liver functions). The well-known psychotropic effects of Delta(9)-tetrahydrocannabinol, which are mediated by activation of brain CB(1) receptors, have greatly limited its clinical use. However, the plant Cannabis contains many cannabinoids with weak or no psychoactivity that, therapeutically, might be more promising than Delta(9)-tetrahydrocannabinol. Here, we provide an overview of the recent pharmacological advances, novel mechanisms of action, and potential therapeutic applications of such non-psychotropic plant-derived cannabinoids. Special emphasis is given to cannabidiol, the possible applications of which have recently emerged in inflammation, diabetes, cancer, affective and neurodegenerative diseases, and to Delta(9)-tetrahydrocannabivarin, a novel CB(1) antagonist which exerts potentially useful actions in the treatment of epilepsy and obesity.

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  • Authors+Show Affiliations

    ,

    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy. aaizzo@unina.it

    , , ,

    Source

    Trends in pharmacological sciences 30:10 2009 Oct pg 515-27

    MeSH

    Animals
    Cannabinoids
    Cannabis
    Humans

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19729208

    Citation

    Izzo, Angelo A., et al. "Non-psychotropic Plant Cannabinoids: New Therapeutic Opportunities From an Ancient Herb." Trends in Pharmacological Sciences, vol. 30, no. 10, 2009, pp. 515-27.
    Izzo AA, Borrelli F, Capasso R, et al. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci. 2009;30(10):515-27.
    Izzo, A. A., Borrelli, F., Capasso, R., Di Marzo, V., & Mechoulam, R. (2009). Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends in Pharmacological Sciences, 30(10), pp. 515-27. doi:10.1016/j.tips.2009.07.006.
    Izzo AA, et al. Non-psychotropic Plant Cannabinoids: New Therapeutic Opportunities From an Ancient Herb. Trends Pharmacol Sci. 2009;30(10):515-27. PubMed PMID: 19729208.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. AU - Izzo,Angelo A, AU - Borrelli,Francesca, AU - Capasso,Raffaele, AU - Di Marzo,Vincenzo, AU - Mechoulam,Raphael, Y1 - 2009/09/02/ PY - 2009/05/20/received PY - 2009/07/09/revised PY - 2009/07/13/accepted PY - 2009/9/5/entrez PY - 2009/9/5/pubmed PY - 2009/12/16/medline SP - 515 EP - 27 JF - Trends in pharmacological sciences JO - Trends Pharmacol. Sci. VL - 30 IS - 10 N2 - Delta(9)-tetrahydrocannabinol binds cannabinoid (CB(1) and CB(2)) receptors, which are activated by endogenous compounds (endocannabinoids) and are involved in a wide range of physiopathological processes (e.g. modulation of neurotransmitter release, regulation of pain perception, and of cardiovascular, gastrointestinal and liver functions). The well-known psychotropic effects of Delta(9)-tetrahydrocannabinol, which are mediated by activation of brain CB(1) receptors, have greatly limited its clinical use. However, the plant Cannabis contains many cannabinoids with weak or no psychoactivity that, therapeutically, might be more promising than Delta(9)-tetrahydrocannabinol. Here, we provide an overview of the recent pharmacological advances, novel mechanisms of action, and potential therapeutic applications of such non-psychotropic plant-derived cannabinoids. Special emphasis is given to cannabidiol, the possible applications of which have recently emerged in inflammation, diabetes, cancer, affective and neurodegenerative diseases, and to Delta(9)-tetrahydrocannabivarin, a novel CB(1) antagonist which exerts potentially useful actions in the treatment of epilepsy and obesity. SN - 1873-3735 UR - https://www.unboundmedicine.com/medline/citation/19729208/Non_psychotropic_plant_cannabinoids:_new_therapeutic_opportunities_from_an_ancient_herb_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-6147(09)00128-X DB - PRIME DP - Unbound Medicine ER -