Tags

Type your tag names separated by a space and hit enter

Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?
Trends Pharmacol Sci. 2009 Sep; 30(9):475-83.TP

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder largely of idiopathic nature with the exceptions of rare familial forms, and is characterized by both motor and non-motor disturbances. Pathologically, most motor features are the result of a dramatic loss of ventral tier mesencephalic dopaminergic neurons and thus dopamine content at their target sites. Although the exact etiology of the disease remains to be elucidated, it is thought to be multifactorial, with a critical role for environmental factors, such as pesticides, that may act on genetically predisposed individuals. Arising from consideration of the potential environmental triggers of PD, in vivo animal models of the disease utilizing these compounds are increasingly reported in the literature. Here, we review recent advances in the predominant models employing the insecticide Rotenone, the herbicide Paraquat and the fungicide Maneb, discuss their scientific merit and evaluate their relevance in the study of PD pathogenesis.

Authors+Show Affiliations

Centre de Recherche du CHUL (CHUQ), Axe Neuroscience, RC-9800, Québec G1V 4G2, Canada. Francesca.Cicchetti@crchul.ulaval.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19729209

Citation

Cicchetti, Francesca, et al. "Environmental Toxins and Parkinson's Disease: what Have We Learned From Pesticide-induced Animal Models?" Trends in Pharmacological Sciences, vol. 30, no. 9, 2009, pp. 475-83.
Cicchetti F, Drouin-Ouellet J, Gross RE. Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models? Trends Pharmacol Sci. 2009;30(9):475-83.
Cicchetti, F., Drouin-Ouellet, J., & Gross, R. E. (2009). Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models? Trends in Pharmacological Sciences, 30(9), 475-83. https://doi.org/10.1016/j.tips.2009.06.005
Cicchetti F, Drouin-Ouellet J, Gross RE. Environmental Toxins and Parkinson's Disease: what Have We Learned From Pesticide-induced Animal Models. Trends Pharmacol Sci. 2009;30(9):475-83. PubMed PMID: 19729209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models? AU - Cicchetti,Francesca, AU - Drouin-Ouellet,Janelle, AU - Gross,Robert E, Y1 - 2009/09/02/ PY - 2009/04/06/received PY - 2009/05/29/revised PY - 2009/06/08/accepted PY - 2009/9/5/entrez PY - 2009/9/5/pubmed PY - 2009/11/10/medline SP - 475 EP - 83 JF - Trends in pharmacological sciences JO - Trends Pharmacol Sci VL - 30 IS - 9 N2 - Parkinson's disease (PD) is a common neurodegenerative disorder largely of idiopathic nature with the exceptions of rare familial forms, and is characterized by both motor and non-motor disturbances. Pathologically, most motor features are the result of a dramatic loss of ventral tier mesencephalic dopaminergic neurons and thus dopamine content at their target sites. Although the exact etiology of the disease remains to be elucidated, it is thought to be multifactorial, with a critical role for environmental factors, such as pesticides, that may act on genetically predisposed individuals. Arising from consideration of the potential environmental triggers of PD, in vivo animal models of the disease utilizing these compounds are increasingly reported in the literature. Here, we review recent advances in the predominant models employing the insecticide Rotenone, the herbicide Paraquat and the fungicide Maneb, discuss their scientific merit and evaluate their relevance in the study of PD pathogenesis. SN - 1873-3735 UR - https://www.unboundmedicine.com/medline/citation/19729209/Environmental_toxins_and_Parkinson's_disease:_what_have_we_learned_from_pesticide_induced_animal_models L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-6147(09)00122-9 DB - PRIME DP - Unbound Medicine ER -