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Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension.
J Hum Hypertens. 1990 Jun; 4(3):227-33.JH

Abstract

Forty-four male in-patients with mild essential hypertension were randomly allocated to three groups and put on diets supplemented with 60 ml/day of olive (n = 15), sunflowerseed (n = 15) or linseed oils (n = 14), respectively, for two weeks within a blind study. In the group receiving sunflowerseed oil an increase of linoleic acid in serum lipids could be observed, whereas arachidonic and eicosapentaenoic acids appeared unchanged in serum triglycerides and even significantly lower in cholesterol esters. The subjects ingesting the linseed oil-rich diet showed an increase of alpha-linolenic acid in serum lipids, whereas arachidonic and eicosapentaenoic acids remained unchanged in serum triglycerides. In cholesterol esters, however, arachidonic acid was significantly decreased and eicosapentaenoic acid appeared increased only to a low level of significance. In the group put on the olive oil-rich regimen only a significant fall of linoleic acid was obvious in serum triglycerides. The results might indicate a defective desaturation and elongation of linoleic and alpha-linolenic acids and, consequently, a slow formation of arachidonic and eicosapentaenoic acids in patients with mild essential hypertension, which should be considered in dietary studies. After the sunflowerseed oil-rich diet a significant decrease of total cholesterol, low density lipoprotein (LDL) cholesterol and the LDL/high density lipoprotein (HDL) cholesterol ratio was found. Systolic blood pressure during a psychophysiological stress test and urinary sodium excretion appeared significantly lower after the linoleic acid-rich diet. After the linseed oil-rich diet, in addition to total cholesterol, LDL cholesterol and the LDL/HDL cholesterol ratio, serum triglycerides and lecithin cholesterol acyl transferase (LCAT) activity were significantly depressed.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Central Institute for Cardiovascular Research, Academy of Sciences, Berlin-Buch, GDR.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1972963

Citation

Singer, P, et al. "Effects of Dietary Oleic, Linoleic and Alpha-linolenic Acids On Blood Pressure, Serum Lipids, Lipoproteins and the Formation of Eicosanoid Precursors in Patients With Mild Essential Hypertension." Journal of Human Hypertension, vol. 4, no. 3, 1990, pp. 227-33.
Singer P, Jaeger W, Berger I, et al. Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. J Hum Hypertens. 1990;4(3):227-33.
Singer, P., Jaeger, W., Berger, I., Barleben, H., Wirth, M., Richter-Heinrich, E., Voigt, S., & Gödicke, W. (1990). Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. Journal of Human Hypertension, 4(3), 227-33.
Singer P, et al. Effects of Dietary Oleic, Linoleic and Alpha-linolenic Acids On Blood Pressure, Serum Lipids, Lipoproteins and the Formation of Eicosanoid Precursors in Patients With Mild Essential Hypertension. J Hum Hypertens. 1990;4(3):227-33. PubMed PMID: 1972963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. AU - Singer,P, AU - Jaeger,W, AU - Berger,I, AU - Barleben,H, AU - Wirth,M, AU - Richter-Heinrich,E, AU - Voigt,S, AU - Gödicke,W, PY - 1990/6/1/pubmed PY - 1990/6/1/medline PY - 1990/6/1/entrez SP - 227 EP - 33 JF - Journal of human hypertension JO - J Hum Hypertens VL - 4 IS - 3 N2 - Forty-four male in-patients with mild essential hypertension were randomly allocated to three groups and put on diets supplemented with 60 ml/day of olive (n = 15), sunflowerseed (n = 15) or linseed oils (n = 14), respectively, for two weeks within a blind study. In the group receiving sunflowerseed oil an increase of linoleic acid in serum lipids could be observed, whereas arachidonic and eicosapentaenoic acids appeared unchanged in serum triglycerides and even significantly lower in cholesterol esters. The subjects ingesting the linseed oil-rich diet showed an increase of alpha-linolenic acid in serum lipids, whereas arachidonic and eicosapentaenoic acids remained unchanged in serum triglycerides. In cholesterol esters, however, arachidonic acid was significantly decreased and eicosapentaenoic acid appeared increased only to a low level of significance. In the group put on the olive oil-rich regimen only a significant fall of linoleic acid was obvious in serum triglycerides. The results might indicate a defective desaturation and elongation of linoleic and alpha-linolenic acids and, consequently, a slow formation of arachidonic and eicosapentaenoic acids in patients with mild essential hypertension, which should be considered in dietary studies. After the sunflowerseed oil-rich diet a significant decrease of total cholesterol, low density lipoprotein (LDL) cholesterol and the LDL/high density lipoprotein (HDL) cholesterol ratio was found. Systolic blood pressure during a psychophysiological stress test and urinary sodium excretion appeared significantly lower after the linoleic acid-rich diet. After the linseed oil-rich diet, in addition to total cholesterol, LDL cholesterol and the LDL/HDL cholesterol ratio, serum triglycerides and lecithin cholesterol acyl transferase (LCAT) activity were significantly depressed.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0950-9240 UR - https://www.unboundmedicine.com/medline/citation/1972963/Effects_of_dietary_oleic_linoleic_and_alpha_linolenic_acids_on_blood_pressure_serum_lipids_lipoproteins_and_the_formation_of_eicosanoid_precursors_in_patients_with_mild_essential_hypertension_ L2 - http://www.diseaseinfosearch.org/result/8360 DB - PRIME DP - Unbound Medicine ER -