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Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial.
Ann Nutr Metab. 2009; 54(4):291-300.AN

Abstract

AIMS

To investigate the effects of a 6-month supplementation with calcium and cholecalciferol on biochemical parameters and muscle strength of institutionalized elderly.

METHODS

This prospective, double-blind, placebo-controlled, randomized trial included Brazilian institutionalized people > or =60 years of age receiving a 6-month supplementation (December to May) of daily calcium plus monthly placebo (calcium/placebo group) or daily calcium plus oral cholecalciferol (150,000 IU once a month during the first 2 months, followed by 90,000 IU once a month for the last 4 months; calcium/vitamin D group). Fasting blood samples for 25(OH)D, PTH and calcium determination were collected (n = 56) and muscle tests were performed (n = 46) to measure the strength of hip flexors (SHF) and knee extensors (SKE) before (baseline) and after the 6-month intervention (6 months).

RESULTS

Due to seasonal variations, serum 25(OH)D significantly enhanced in both groups after treatment, but the calcium/vitamin D group had significantly higher 25 (OH)D levels than the calcium/placebo group (84 vs. 33%, respectively; p < 0.0001). No cases of hypercalcemia were observed. While the calcium/placebo group showed no improvement in SHF and SKE at 6 months (p = 0.93 and p = 0.61, respectively), SHF was increased in the calcium/vitamin D group by 16.4% (p = 0.0001) and SKE by 24.6% (p = 0.0007).

CONCLUSIONS

The suggested cholecalciferol supplementation was safe and efficient in enhancing 25(OH)D levels and lower limb muscle strength in the elderly, in the absence of any regular physical exercise practice.

Authors+Show Affiliations

Division of Endocrinology, School of Medicine, Federal University of São Paulo/UNIFESP, São Paulo, Brazil. lindapfrimer@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19729890

Citation

Moreira-Pfrimer, Linda D F., et al. "Treatment of Vitamin D Deficiency Increases Lower Limb Muscle Strength in Institutionalized Older People Independently of Regular Physical Activity: a Randomized Double-blind Controlled Trial." Annals of Nutrition & Metabolism, vol. 54, no. 4, 2009, pp. 291-300.
Moreira-Pfrimer LD, Pedrosa MA, Teixeira L, et al. Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial. Ann Nutr Metab. 2009;54(4):291-300.
Moreira-Pfrimer, L. D., Pedrosa, M. A., Teixeira, L., & Lazaretti-Castro, M. (2009). Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial. Annals of Nutrition & Metabolism, 54(4), 291-300. https://doi.org/10.1159/000235874
Moreira-Pfrimer LD, et al. Treatment of Vitamin D Deficiency Increases Lower Limb Muscle Strength in Institutionalized Older People Independently of Regular Physical Activity: a Randomized Double-blind Controlled Trial. Ann Nutr Metab. 2009;54(4):291-300. PubMed PMID: 19729890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial. AU - Moreira-Pfrimer,Linda D F, AU - Pedrosa,Márcia A C, AU - Teixeira,Luzimar, AU - Lazaretti-Castro,Marise, Y1 - 2009/08/31/ PY - 2008/09/09/received PY - 2009/05/29/accepted PY - 2009/9/5/entrez PY - 2009/9/5/pubmed PY - 2010/1/13/medline SP - 291 EP - 300 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 54 IS - 4 N2 - AIMS: To investigate the effects of a 6-month supplementation with calcium and cholecalciferol on biochemical parameters and muscle strength of institutionalized elderly. METHODS: This prospective, double-blind, placebo-controlled, randomized trial included Brazilian institutionalized people > or =60 years of age receiving a 6-month supplementation (December to May) of daily calcium plus monthly placebo (calcium/placebo group) or daily calcium plus oral cholecalciferol (150,000 IU once a month during the first 2 months, followed by 90,000 IU once a month for the last 4 months; calcium/vitamin D group). Fasting blood samples for 25(OH)D, PTH and calcium determination were collected (n = 56) and muscle tests were performed (n = 46) to measure the strength of hip flexors (SHF) and knee extensors (SKE) before (baseline) and after the 6-month intervention (6 months). RESULTS: Due to seasonal variations, serum 25(OH)D significantly enhanced in both groups after treatment, but the calcium/vitamin D group had significantly higher 25 (OH)D levels than the calcium/placebo group (84 vs. 33%, respectively; p < 0.0001). No cases of hypercalcemia were observed. While the calcium/placebo group showed no improvement in SHF and SKE at 6 months (p = 0.93 and p = 0.61, respectively), SHF was increased in the calcium/vitamin D group by 16.4% (p = 0.0001) and SKE by 24.6% (p = 0.0007). CONCLUSIONS: The suggested cholecalciferol supplementation was safe and efficient in enhancing 25(OH)D levels and lower limb muscle strength in the elderly, in the absence of any regular physical exercise practice. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/19729890/Treatment_of_vitamin_D_deficiency_increases_lower_limb_muscle_strength_in_institutionalized_older_people_independently_of_regular_physical_activity:_a_randomized_double_blind_controlled_trial_ L2 - https://www.karger.com?DOI=10.1159/000235874 DB - PRIME DP - Unbound Medicine ER -