Tags

Type your tag names separated by a space and hit enter

Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight.
J Vasc Res. 2010; 47(2):139-47.JV

Abstract

BACKGROUND

Low birth weight (LBW) is associated with increased risk of type 2 diabetes and cardiovascular disease. We studied endothelial function and insulin sensitivity in young men with LBW (n = 22) and controls (n = 22).

METHODS

Insulin sensitivity and endothelial function was studied with venous occlusion plethysmography and intra-arterial infusions of adenosine and acetylcholine, before and during a hyperinsulinemic isoglycemic clamp.

RESULTS

Forearm blood flow response to systemic hyperinsulinemia was diminished in LBW compared to controls (p < 0.05). Fractional arteriovenous glucose extraction was similar, and consequently insulin-stimulated forearm glucose clearance was diminished in LBW compared with controls (0.8 +/- 0.09 vs. 1.4 +/- 0.36 ml x 100 ml(-1) x min(-1), respectively, p < 0.05). Forearm blood flow response to adenosine and acetylcholine with or without insulin stimulation did not differ between groups. Whole-body glucose uptake was lower in LBW than controls (8.7 +/- 0.5 and 9.1 +/- 0.6 mg x min(-1) x kg(-1) lean body mass); however, this was not significant.

CONCLUSIONS

Forearm blood flow response to insulin is impaired in LBW, whereas the response to adenosine and acetylcholine is preserved. The impaired insulin-mediated increase in bulk flow in LBW may be due to an impairment of insulin-mediated capillary recruitment independent of - or preceding - whole-body insulin resistance in LBW subjects.

Authors+Show Affiliations

Department of Biomedical Sciences, Section of Systems Biology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. msonne@mfi.ku.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19729960

Citation

Sonne, M P., et al. "Diminished Insulin-mediated Forearm Blood Flow and Muscle Glucose Uptake in Young Men With Low Birth Weight." Journal of Vascular Research, vol. 47, no. 2, 2010, pp. 139-47.
Sonne MP, Højbjerre L, Alibegovic AC, et al. Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight. J Vasc Res. 2010;47(2):139-47.
Sonne, M. P., Højbjerre, L., Alibegovic, A. C., Vaag, A., Stallknecht, B., & Dela, F. (2010). Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight. Journal of Vascular Research, 47(2), 139-47. https://doi.org/10.1159/000235968
Sonne MP, et al. Diminished Insulin-mediated Forearm Blood Flow and Muscle Glucose Uptake in Young Men With Low Birth Weight. J Vasc Res. 2010;47(2):139-47. PubMed PMID: 19729960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight. AU - Sonne,M P, AU - Højbjerre,L, AU - Alibegovic,A C, AU - Vaag,A, AU - Stallknecht,B, AU - Dela,F, Y1 - 2009/09/04/ PY - 2008/09/26/received PY - 2009/04/17/accepted PY - 2009/9/5/entrez PY - 2009/9/5/pubmed PY - 2010/3/5/medline SP - 139 EP - 47 JF - Journal of vascular research JO - J Vasc Res VL - 47 IS - 2 N2 - BACKGROUND: Low birth weight (LBW) is associated with increased risk of type 2 diabetes and cardiovascular disease. We studied endothelial function and insulin sensitivity in young men with LBW (n = 22) and controls (n = 22). METHODS: Insulin sensitivity and endothelial function was studied with venous occlusion plethysmography and intra-arterial infusions of adenosine and acetylcholine, before and during a hyperinsulinemic isoglycemic clamp. RESULTS: Forearm blood flow response to systemic hyperinsulinemia was diminished in LBW compared to controls (p < 0.05). Fractional arteriovenous glucose extraction was similar, and consequently insulin-stimulated forearm glucose clearance was diminished in LBW compared with controls (0.8 +/- 0.09 vs. 1.4 +/- 0.36 ml x 100 ml(-1) x min(-1), respectively, p < 0.05). Forearm blood flow response to adenosine and acetylcholine with or without insulin stimulation did not differ between groups. Whole-body glucose uptake was lower in LBW than controls (8.7 +/- 0.5 and 9.1 +/- 0.6 mg x min(-1) x kg(-1) lean body mass); however, this was not significant. CONCLUSIONS: Forearm blood flow response to insulin is impaired in LBW, whereas the response to adenosine and acetylcholine is preserved. The impaired insulin-mediated increase in bulk flow in LBW may be due to an impairment of insulin-mediated capillary recruitment independent of - or preceding - whole-body insulin resistance in LBW subjects. SN - 1423-0135 UR - https://www.unboundmedicine.com/medline/citation/19729960/Diminished_insulin_mediated_forearm_blood_flow_and_muscle_glucose_uptake_in_young_men_with_low_birth_weight_ L2 - https://www.karger.com?DOI=10.1159/000235968 DB - PRIME DP - Unbound Medicine ER -