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Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice.

Abstract

Obesity is a potential risk factor for cognitive deficits in the elder humans. Using a high-fat diet (HFD)-induced obese mouse model, we investigated the impacts of HFD on obesity, metabolic and stress hormones, learning performance, and hippocampal synaptic plasticity. Both male and female C57BL/6J mice fed with HFD (3 weeks to 9-12 months) gained significantly more weights than the sex-specific control groups. Compared with the obese female mice, the obese males had similar energy intake but developed more weight gains. The obese male mice developed hyperglycemia, hyperinsulinemia, hypercholesterolemia, and hyperleptinemia, but not hypertriglyceridemia. The obese females had less hyperinsulinemia and hypercholesterolemia than the obese males, and no hyperglycemia and hypertriglyceridemia. In the contextual fear conditioning and step-down passive avoidance tasks, the obese male, but not female, mice showed poorer learning performance than their normal counterparts. These learning deficits were not due to sensorimotor impairment as verified by the open-field and hot-plate tests. Although, basal synaptic transmission characteristics (input-output transfer and paired-pulse facilitation (PPF) ratio) were not significantly different between normal and HFD groups, the magnitudes of synaptic plasticity (long-term potentiation (LTP) and long-term depression (LTD)) were lower at the Schaffer collateral-CA1 synapses of the hippocampal slices isolated from the obese male, but not female, mice, as compared with their sex-specific controls. Our results suggest that male mice are more vulnerable than the females to the impacts of HFD on weight gains, metabolic alterations and deficits of learning, and hippocampal synaptic plasticity.

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  • Authors+Show Affiliations

    ,

    Department of Physiology, College of Medicine, Taipei Medical University, Taipei, Taiwan.

    , , , , , , , , ,

    Source

    Obesity (Silver Spring, Md.) 18:3 2010 Mar pg 463-9

    MeSH

    Animals
    Avoidance Learning
    Cognition Disorders
    Conditioning, Classical
    Dietary Fats
    Disease Models, Animal
    Energy Intake
    Fear
    Female
    Hippocampus
    Hyperglycemia
    Hyperinsulinism
    Hyperlipidemias
    Learning
    Long-Term Synaptic Depression
    Male
    Metabolic Diseases
    Mice
    Mice, Inbred C57BL
    Neuronal Plasticity
    Obesity
    Random Allocation
    Sex Factors
    Synaptic Transmission
    Weight Gain

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19730425

    Citation

    Hwang, Ling-Ling, et al. "Sex Differences in High-fat Diet-induced Obesity, Metabolic Alterations and Learning, and Synaptic Plasticity Deficits in Mice." Obesity (Silver Spring, Md.), vol. 18, no. 3, 2010, pp. 463-9.
    Hwang LL, Wang CH, Li TL, et al. Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice. Obesity (Silver Spring). 2010;18(3):463-9.
    Hwang, L. L., Wang, C. H., Li, T. L., Chang, S. D., Lin, L. C., Chen, C. P., ... Chiou, L. C. (2010). Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice. Obesity (Silver Spring, Md.), 18(3), pp. 463-9. doi:10.1038/oby.2009.273.
    Hwang LL, et al. Sex Differences in High-fat Diet-induced Obesity, Metabolic Alterations and Learning, and Synaptic Plasticity Deficits in Mice. Obesity (Silver Spring). 2010;18(3):463-9. PubMed PMID: 19730425.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice. AU - Hwang,Ling-Ling, AU - Wang,Chien-Hua, AU - Li,Tzu-Ling, AU - Chang,Shih-Dar, AU - Lin,Li-Chun, AU - Chen,Ching-Ping, AU - Chen,Chiung-Tong, AU - Liang,Keng-Chen, AU - Ho,Ing-Kang, AU - Yang,Wei-Shiung, AU - Chiou,Lih-Chu, Y1 - 2009/09/03/ PY - 2009/9/5/entrez PY - 2009/9/5/pubmed PY - 2010/8/14/medline SP - 463 EP - 9 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 18 IS - 3 N2 - Obesity is a potential risk factor for cognitive deficits in the elder humans. Using a high-fat diet (HFD)-induced obese mouse model, we investigated the impacts of HFD on obesity, metabolic and stress hormones, learning performance, and hippocampal synaptic plasticity. Both male and female C57BL/6J mice fed with HFD (3 weeks to 9-12 months) gained significantly more weights than the sex-specific control groups. Compared with the obese female mice, the obese males had similar energy intake but developed more weight gains. The obese male mice developed hyperglycemia, hyperinsulinemia, hypercholesterolemia, and hyperleptinemia, but not hypertriglyceridemia. The obese females had less hyperinsulinemia and hypercholesterolemia than the obese males, and no hyperglycemia and hypertriglyceridemia. In the contextual fear conditioning and step-down passive avoidance tasks, the obese male, but not female, mice showed poorer learning performance than their normal counterparts. These learning deficits were not due to sensorimotor impairment as verified by the open-field and hot-plate tests. Although, basal synaptic transmission characteristics (input-output transfer and paired-pulse facilitation (PPF) ratio) were not significantly different between normal and HFD groups, the magnitudes of synaptic plasticity (long-term potentiation (LTP) and long-term depression (LTD)) were lower at the Schaffer collateral-CA1 synapses of the hippocampal slices isolated from the obese male, but not female, mice, as compared with their sex-specific controls. Our results suggest that male mice are more vulnerable than the females to the impacts of HFD on weight gains, metabolic alterations and deficits of learning, and hippocampal synaptic plasticity. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/19730425/Sex_differences_in_high_fat_diet_induced_obesity_metabolic_alterations_and_learning_and_synaptic_plasticity_deficits_in_mice_ L2 - https://doi.org/10.1038/oby.2009.273 DB - PRIME DP - Unbound Medicine ER -