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Non-dipping pattern in ambulatory blood pressure monitoring is associated with metabolic abnormalities in a random sample of middle-aged subjects.
Hypertens Res. 2009 Nov; 32(11):1022-7.HR

Abstract

A reduction in the blood pressure decline at night (<10% from daytime systolic blood pressure (SBP)) during 24-h ambulatory blood pressure monitoring (ABPM) ('non-dipping pattern') is associated with cardiovascular morbidity. Our aim was to evaluate whether ABPM characteristics are associated with metabolic abnormalities in subjects without known hypertension or type 2 diabetes mellitus (T2DM). This is a cross-sectional population-based study on middle-aged subjects (n=462). Two distinct definitions of metabolic syndrome (MetS) were used: National Cholesterol Education Program-Third Adult Treatment Panel (NCEP-ATPIII) and International Diabetes Federation (IDF) criteria. Results suggested that subjects characterized by non-dipping in 24 h ABPM were more obese (P=0.014). After adjustment for body mass index, age and sex, non-dippers had higher very-low-density lipoprotein (VLDL)-cholesterol (P=0.003), total (P=0.029)-and VLDL-triglycerides (P=0.026) and oral glucose tolerance test 2 h blood glucose (P=0.027) compared with dippers. Non-dipping status was more common among subjects with MetS (P< or =0.01), impaired glucose tolerance (IGT) (P<0.05) and in those with the combination of IGT-T2DM (P< or =0.01) than among those without these abnormalities. ABPM non-dipping status was an independent predictor of IGT in multivariate models (P<0.05). With respect to MetS components, high triglycerides (P< or =0.005) and low high density lipoprotein-cholesterol (P<0.05) were associated with a non-dipping pattern. The percentage decline in blood pressure from day to night decreased with the number of metabolic abnormalities (P=0.012). In conclusion, ABPM non-dipping status is an independent predictor of glucose intolerance. It is also associated with several other metabolic abnormalities. Whether non-dipping pattern is causally related to these metabolic aberrations remains to be explored in a future prospective follow-up of this cohort.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ukkola O
Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, and Clinical Research Center, Oulu University Hospital, Oulu, Finland. olavi.ukkola@oulu.fi
Vasunta RL
No affiliation info available
Kesäniemi YA
No affiliation info available

MeSH

Blood GlucoseBlood PressureBlood Pressure Monitoring, AmbulatoryCircadian RhythmCohort StudiesDiabetes Mellitus, Type 2FemaleGlucose IntoleranceHumansInsulinLipoproteins, VLDLLogistic ModelsMaleMetabolic DiseasesMetabolic SyndromeMiddle AgedRisk FactorsTriglycerides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19730439

Citation

Ukkola, Olavi, et al. "Non-dipping Pattern in Ambulatory Blood Pressure Monitoring Is Associated With Metabolic Abnormalities in a Random Sample of Middle-aged Subjects." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 32, no. 11, 2009, pp. 1022-7.
Ukkola O, Vasunta RL, Kesäniemi YA. Non-dipping pattern in ambulatory blood pressure monitoring is associated with metabolic abnormalities in a random sample of middle-aged subjects. Hypertens Res. 2009;32(11):1022-7.
Ukkola, O., Vasunta, R. L., & Kesäniemi, Y. A. (2009). Non-dipping pattern in ambulatory blood pressure monitoring is associated with metabolic abnormalities in a random sample of middle-aged subjects. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 32(11), 1022-7. https://doi.org/10.1038/hr.2009.137
Ukkola O, Vasunta RL, Kesäniemi YA. Non-dipping Pattern in Ambulatory Blood Pressure Monitoring Is Associated With Metabolic Abnormalities in a Random Sample of Middle-aged Subjects. Hypertens Res. 2009;32(11):1022-7. PubMed PMID: 19730439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-dipping pattern in ambulatory blood pressure monitoring is associated with metabolic abnormalities in a random sample of middle-aged subjects. AU - Ukkola,Olavi, AU - Vasunta,Riitta-Liisa, AU - Kesäniemi,Y Antero, Y1 - 2009/09/04/ PY - 2009/9/5/entrez PY - 2009/9/5/pubmed PY - 2010/1/13/medline SP - 1022 EP - 7 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens Res VL - 32 IS - 11 N2 - A reduction in the blood pressure decline at night (<10% from daytime systolic blood pressure (SBP)) during 24-h ambulatory blood pressure monitoring (ABPM) ('non-dipping pattern') is associated with cardiovascular morbidity. Our aim was to evaluate whether ABPM characteristics are associated with metabolic abnormalities in subjects without known hypertension or type 2 diabetes mellitus (T2DM). This is a cross-sectional population-based study on middle-aged subjects (n=462). Two distinct definitions of metabolic syndrome (MetS) were used: National Cholesterol Education Program-Third Adult Treatment Panel (NCEP-ATPIII) and International Diabetes Federation (IDF) criteria. Results suggested that subjects characterized by non-dipping in 24 h ABPM were more obese (P=0.014). After adjustment for body mass index, age and sex, non-dippers had higher very-low-density lipoprotein (VLDL)-cholesterol (P=0.003), total (P=0.029)-and VLDL-triglycerides (P=0.026) and oral glucose tolerance test 2 h blood glucose (P=0.027) compared with dippers. Non-dipping status was more common among subjects with MetS (P< or =0.01), impaired glucose tolerance (IGT) (P<0.05) and in those with the combination of IGT-T2DM (P< or =0.01) than among those without these abnormalities. ABPM non-dipping status was an independent predictor of IGT in multivariate models (P<0.05). With respect to MetS components, high triglycerides (P< or =0.005) and low high density lipoprotein-cholesterol (P<0.05) were associated with a non-dipping pattern. The percentage decline in blood pressure from day to night decreased with the number of metabolic abnormalities (P=0.012). In conclusion, ABPM non-dipping status is an independent predictor of glucose intolerance. It is also associated with several other metabolic abnormalities. Whether non-dipping pattern is causally related to these metabolic aberrations remains to be explored in a future prospective follow-up of this cohort. SN - 1348-4214 UR - https://www.unboundmedicine.com/medline/citation/19730439/Non_dipping_pattern_in_ambulatory_blood_pressure_monitoring_is_associated_with_metabolic_abnormalities_in_a_random_sample_of_middle_aged_subjects_ L2 - https://medlineplus.gov/metabolicdisorders.html DB - PRIME DP - Unbound Medicine ER -