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Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone.
Nat Prod Res. 2009; 23(13):1231-9.NP

Abstract

Microbial transformation of 7,8-dimethoxyflavone (1) by Mucor ramannianus produced five metabolites: 7,8-dimethoxy-4'-hydroxyflavone (2), 3',4'-dihydroxy-7,8-dimethoxyflavone (3), 7,3'-dihydroxy-8-methoxyflavone (4), 7,4'-dihydroxy-8-methoxyflavone (5) and 8-methoxy-7,3',4'-trihydroxyflavone (6). It was, however, completely converted to a single metabolite, 7-hydroxy-8-methoxyflavone (7) by Aspergillus flavus. 5-Methoxyflavone (8), when fermented with Beauveria bassiana, gave a single product, 5-methoxyflavanone (9). Conversion of 8 with Aspergillus alliaceus yielded the metabolite 4'-hydroxy-5-methoxyflavone (10). The structures of the compounds 2-7, 9 and 10 were established by spectroscopic methods.

Authors+Show Affiliations

National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19731142

Citation

Herath, Wimal, et al. "Microbial Metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone." Natural Product Research, vol. 23, no. 13, 2009, pp. 1231-9.
Herath W, Rakel Mikell J, Ahmad Khan I. Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone. Nat Prod Res. 2009;23(13):1231-9.
Herath, W., Rakel Mikell, J., & Ahmad Khan, I. (2009). Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone. Natural Product Research, 23(13), 1231-9. https://doi.org/10.1080/14786410902829797
Herath W, Rakel Mikell J, Ahmad Khan I. Microbial Metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone. Nat Prod Res. 2009;23(13):1231-9. PubMed PMID: 19731142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone. AU - Herath,Wimal, AU - Rakel Mikell,Julie, AU - Ahmad Khan,Ikhlas, PY - 2009/9/5/entrez PY - 2009/9/5/pubmed PY - 2009/12/16/medline SP - 1231 EP - 9 JF - Natural product research JO - Nat. Prod. Res. VL - 23 IS - 13 N2 - Microbial transformation of 7,8-dimethoxyflavone (1) by Mucor ramannianus produced five metabolites: 7,8-dimethoxy-4'-hydroxyflavone (2), 3',4'-dihydroxy-7,8-dimethoxyflavone (3), 7,3'-dihydroxy-8-methoxyflavone (4), 7,4'-dihydroxy-8-methoxyflavone (5) and 8-methoxy-7,3',4'-trihydroxyflavone (6). It was, however, completely converted to a single metabolite, 7-hydroxy-8-methoxyflavone (7) by Aspergillus flavus. 5-Methoxyflavone (8), when fermented with Beauveria bassiana, gave a single product, 5-methoxyflavanone (9). Conversion of 8 with Aspergillus alliaceus yielded the metabolite 4'-hydroxy-5-methoxyflavone (10). The structures of the compounds 2-7, 9 and 10 were established by spectroscopic methods. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/19731142/Microbial_metabolism__Part_10:_Metabolites_of_78_dimethoxyflavone_and_5_methoxyflavone_ L2 - http://www.tandfonline.com/doi/full/10.1080/14786410902829797 DB - PRIME DP - Unbound Medicine ER -