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Bioactive triterpenes from Diospyros blancoi.
Nat Prod Res. 2009; 23(13):1252-8.NP

Abstract

The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of alpha-amyrin palmitate, alpha-amyrin palmitoleate, beta-amyrin palmitate and beta-amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1 and 2 exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Trichophyton mentagrophytes, and were found inactive against Bacillus subtilis and Aspergillus niger. Sample 2 exhibited significant analgaesic and anti-inflammatory activities.

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Authors+Show Affiliations

Ragasa CY
Chemistry Department, Center for Natural Sciences and Ecological Research, De La Salle University, 1004 Manila, Philippines. ragasac@dlsu.edu.ph
Puno MR
No affiliation info available
Sengson JM
No affiliation info available
Shen CC
No affiliation info available
Rideout JA
No affiliation info available
Raga DD
No affiliation info available

MeSH

Anti-Infective AgentsAspergillus nigerBacillus subtilisBacteriaCandida albicansDiospyrosEscherichia coliFungiMicrobial Sensitivity TestsMolecular StructureStaphylococcus aureusTrichophytonTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19731144

Citation

Ragasa, Consolacion Y., et al. "Bioactive Triterpenes From Diospyros Blancoi." Natural Product Research, vol. 23, no. 13, 2009, pp. 1252-8.
Ragasa CY, Puno MR, Sengson JM, et al. Bioactive triterpenes from Diospyros blancoi. Nat Prod Res. 2009;23(13):1252-8.
Ragasa, C. Y., Puno, M. R., Sengson, J. M., Shen, C. C., Rideout, J. A., & Raga, D. D. (2009). Bioactive triterpenes from Diospyros blancoi. Natural Product Research, 23(13), 1252-8. https://doi.org/10.1080/14786410902951054
Ragasa CY, et al. Bioactive Triterpenes From Diospyros Blancoi. Nat Prod Res. 2009;23(13):1252-8. PubMed PMID: 19731144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive triterpenes from Diospyros blancoi. AU - Ragasa,Consolacion Y, AU - Puno,Marc Rhyan Anthony, AU - Sengson,Josephine Marie Angeline P, AU - Shen,Chien-Chang, AU - Rideout,John A, AU - Raga,Dennis D, PY - 2009/9/5/entrez PY - 2009/9/5/pubmed PY - 2009/12/16/medline SP - 1252 EP - 8 JF - Natural product research JO - Nat Prod Res VL - 23 IS - 13 N2 - The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of alpha-amyrin palmitate, alpha-amyrin palmitoleate, beta-amyrin palmitate and beta-amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1 and 2 exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Trichophyton mentagrophytes, and were found inactive against Bacillus subtilis and Aspergillus niger. Sample 2 exhibited significant analgaesic and anti-inflammatory activities. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/19731144/Bioactive_triterpenes_from_Diospyros_blancoi_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786410902951054 DB - PRIME DP - Unbound Medicine ER -