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Amygdala volume in a population with special educational needs at high risk of schizophrenia.
Psychol Med. 2010 Jun; 40(6):945-54.PM

Abstract

BACKGROUND

The mildly learning disabled population has a three-fold elevated risk for schizophrenia. It has been proposed that in some individuals this cognitive limitation is a pre-psychotic manifestation of early onset schizophrenia. We examined clinical and neuroanatomical measures of a putative extended phenotype of schizophrenia in an adolescent population receiving special educational assistance. We predicted that people with intellectual impairment and schizotypal features would exhibit amygdala volume reduction as one of the neuroanatomical abnormalities associated with schizophrenia.

METHOD

Assessment by clinical interview, neuropsychological assessment and magnetic resonance imaging scanning was carried out in 28 intellectually impaired individuals identified as being at elevated risk of schizophrenia due to the presence of schizotypal traits, 39 intellectually impaired controls and 29 non-intellectually impaired controls. Amygdala volume was compared in these three groups and the relationship between symptomatology and amygdala volume investigated.

RESULTS

Right amygdala volume was significantly increased in the elevated risk group compared with the intellectually impaired controls (p=0.05). A significant negative correlation was seen between left amygdala volume and severity of negative symptoms within this group (p<0.05), but not in either control group.

CONCLUSIONS

Intellectually impaired subjects judged to be at elevated risk of schizophrenia on the basis of clinical assessment exhibit structural imaging findings which distinguish them from the generality of learning disabled subjects. Within this population reduced amygdala volume may be associated with negative-type symptoms and be part of an extended phenotype that reflects particularly elevated risk and/or early manifestations of the development of psychosis.

Authors+Show Affiliations

Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh EH10 5HF, UK. kwelch1@staffmail.ed.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19732477

Citation

Welch, K A., et al. "Amygdala Volume in a Population With Special Educational Needs at High Risk of Schizophrenia." Psychological Medicine, vol. 40, no. 6, 2010, pp. 945-54.
Welch KA, Stanfield AC, Moorhead TW, et al. Amygdala volume in a population with special educational needs at high risk of schizophrenia. Psychol Med. 2010;40(6):945-54.
Welch, K. A., Stanfield, A. C., Moorhead, T. W., Haga, K., Owens, D. C., Lawrie, S. M., & Johnstone, E. C. (2010). Amygdala volume in a population with special educational needs at high risk of schizophrenia. Psychological Medicine, 40(6), 945-54. https://doi.org/10.1017/S0033291709990870
Welch KA, et al. Amygdala Volume in a Population With Special Educational Needs at High Risk of Schizophrenia. Psychol Med. 2010;40(6):945-54. PubMed PMID: 19732477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amygdala volume in a population with special educational needs at high risk of schizophrenia. AU - Welch,K A, AU - Stanfield,A C, AU - Moorhead,T W, AU - Haga,K, AU - Owens,D C G, AU - Lawrie,S M, AU - Johnstone,E C, Y1 - 2009/09/07/ PY - 2009/9/8/entrez PY - 2009/9/8/pubmed PY - 2010/8/4/medline SP - 945 EP - 54 JF - Psychological medicine JO - Psychol Med VL - 40 IS - 6 N2 - BACKGROUND: The mildly learning disabled population has a three-fold elevated risk for schizophrenia. It has been proposed that in some individuals this cognitive limitation is a pre-psychotic manifestation of early onset schizophrenia. We examined clinical and neuroanatomical measures of a putative extended phenotype of schizophrenia in an adolescent population receiving special educational assistance. We predicted that people with intellectual impairment and schizotypal features would exhibit amygdala volume reduction as one of the neuroanatomical abnormalities associated with schizophrenia. METHOD: Assessment by clinical interview, neuropsychological assessment and magnetic resonance imaging scanning was carried out in 28 intellectually impaired individuals identified as being at elevated risk of schizophrenia due to the presence of schizotypal traits, 39 intellectually impaired controls and 29 non-intellectually impaired controls. Amygdala volume was compared in these three groups and the relationship between symptomatology and amygdala volume investigated. RESULTS: Right amygdala volume was significantly increased in the elevated risk group compared with the intellectually impaired controls (p=0.05). A significant negative correlation was seen between left amygdala volume and severity of negative symptoms within this group (p<0.05), but not in either control group. CONCLUSIONS: Intellectually impaired subjects judged to be at elevated risk of schizophrenia on the basis of clinical assessment exhibit structural imaging findings which distinguish them from the generality of learning disabled subjects. Within this population reduced amygdala volume may be associated with negative-type symptoms and be part of an extended phenotype that reflects particularly elevated risk and/or early manifestations of the development of psychosis. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/19732477/Amygdala_volume_in_a_population_with_special_educational_needs_at_high_risk_of_schizophrenia_ L2 - https://www.cambridge.org/core/product/identifier/S0033291709990870/type/journal_article DB - PRIME DP - Unbound Medicine ER -