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delta-Aminolevulinic acid dehydratase activity, urinary delta-aminolevulinic acid concentration and zinc protoporphyrin level among people with low level of lead exposure.
Int J Hyg Environ Health. 2010 Jan; 213(1):52-8.IJ

Abstract

To evaluate the relationship of delta-aminolevulinic acid dehydratase (ALAD) activity, urinary delta-aminolevulinic acid (ALAU) level and blood zinc protoporphyrin (ZPP) concentration to low blood lead (PbB) levels, these biomarkers were determined for all subjects enrolled from a rural area of southeast China where people had low levels of exposure to lead. The mean values of PbB, ALAD, ALAU and ZPP were 67.11 microg/L (SD: 1.654, range: 10.90-514.04), 339.66 nmol ml(-1)h(-1) (1.419, 78.33-793.13), 20.64 microg/L (1.603, 2.00-326.00), and 0.14 micromol/L (3.437, 0.01-2.26), respectively. ALAD was inversely associated with low levels of PbB. ZPP was inversely related to low levels of PbB but positively related to relatively higher levels of PbB. Alcohol drinking contributed to low ALAD in men. Women had higher ZPP than men. ALAU had no significant association with PbB. In conclusion, ALAD possibly has a non-linear relation with low to moderate levels of PbB. At moderate levels of PbB, ZPP increases with increasing levels of PbB. ALAU is not suitable as an indicator for low levels of lead exposure.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19733117

Citation

Wang, Qi, et al. "Delta-Aminolevulinic Acid Dehydratase Activity, Urinary Delta-aminolevulinic Acid Concentration and Zinc Protoporphyrin Level Among People With Low Level of Lead Exposure." International Journal of Hygiene and Environmental Health, vol. 213, no. 1, 2010, pp. 52-8.
Wang Q, Zhao HH, Chen JW, et al. Delta-Aminolevulinic acid dehydratase activity, urinary delta-aminolevulinic acid concentration and zinc protoporphyrin level among people with low level of lead exposure. Int J Hyg Environ Health. 2010;213(1):52-8.
Wang, Q., Zhao, H. H., Chen, J. W., Hao, Q. L., Gu, K. D., Zhu, Y. X., Zhou, Y. K., & Ye, L. X. (2010). Delta-Aminolevulinic acid dehydratase activity, urinary delta-aminolevulinic acid concentration and zinc protoporphyrin level among people with low level of lead exposure. International Journal of Hygiene and Environmental Health, 213(1), 52-8. https://doi.org/10.1016/j.ijheh.2009.08.003
Wang Q, et al. Delta-Aminolevulinic Acid Dehydratase Activity, Urinary Delta-aminolevulinic Acid Concentration and Zinc Protoporphyrin Level Among People With Low Level of Lead Exposure. Int J Hyg Environ Health. 2010;213(1):52-8. PubMed PMID: 19733117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - delta-Aminolevulinic acid dehydratase activity, urinary delta-aminolevulinic acid concentration and zinc protoporphyrin level among people with low level of lead exposure. AU - Wang,Qi, AU - Zhao,Huan-hu, AU - Chen,Jian-wei, AU - Hao,Qiao-ling, AU - Gu,Kang-ding, AU - Zhu,Ye-xiang, AU - Zhou,Yi-kai, AU - Ye,Lin-xiang, Y1 - 2009/09/04/ PY - 2009/04/07/received PY - 2009/06/29/revised PY - 2009/08/15/accepted PY - 2009/9/8/entrez PY - 2009/9/8/pubmed PY - 2010/4/9/medline SP - 52 EP - 8 JF - International journal of hygiene and environmental health JO - Int J Hyg Environ Health VL - 213 IS - 1 N2 - To evaluate the relationship of delta-aminolevulinic acid dehydratase (ALAD) activity, urinary delta-aminolevulinic acid (ALAU) level and blood zinc protoporphyrin (ZPP) concentration to low blood lead (PbB) levels, these biomarkers were determined for all subjects enrolled from a rural area of southeast China where people had low levels of exposure to lead. The mean values of PbB, ALAD, ALAU and ZPP were 67.11 microg/L (SD: 1.654, range: 10.90-514.04), 339.66 nmol ml(-1)h(-1) (1.419, 78.33-793.13), 20.64 microg/L (1.603, 2.00-326.00), and 0.14 micromol/L (3.437, 0.01-2.26), respectively. ALAD was inversely associated with low levels of PbB. ZPP was inversely related to low levels of PbB but positively related to relatively higher levels of PbB. Alcohol drinking contributed to low ALAD in men. Women had higher ZPP than men. ALAU had no significant association with PbB. In conclusion, ALAD possibly has a non-linear relation with low to moderate levels of PbB. At moderate levels of PbB, ZPP increases with increasing levels of PbB. ALAU is not suitable as an indicator for low levels of lead exposure. SN - 1618-131X UR - https://www.unboundmedicine.com/medline/citation/19733117/delta_Aminolevulinic_acid_dehydratase_activity_urinary_delta_aminolevulinic_acid_concentration_and_zinc_protoporphyrin_level_among_people_with_low_level_of_lead_exposure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1438-4639(09)00101-1 DB - PRIME DP - Unbound Medicine ER -