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Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population.
Clin Biochem. 2009 Nov; 42(16-17):1642-7.CB

Abstract

OBJECTIVES

This study was undertaken to investigate the impact of the Pro12Ala (rs1801282) polymorphism of the peroxisome proliferator-activated receptor gamma-2 (PPARgamma-2) gene on obesity or body mass index (BMI) and plasma leptin, insulin, adiponectin and lipid levels in a sample of the Tunisian population.

DESIGN AND METHODS

The study included 387 obese patients and 288 control subjects. The Pro12Ala genotype was determined by polymerase chain reaction followed by a digestion with the restriction of endonuclease BstUI.

RESULTS

In the whole population, there is no significant difference in genotype frequencies of the Pro12Ala polymorphism between obese patients and controls. However, separate analysis by gender revealed that obese men (but not women) had significantly higher frequency of Pro/Ala genotypes compared to controls (12.2% vs. 4.1%; chi(2)=6.76, p=0.009). In comparison to Pro/Pro homozygotes, Ala-allele bearers had a significantly higher risk of obesity [OR (95% CI)=3.26 (1.28-8.33)]. When obese subjects were stratified according to type 2 diabetes status, the association with obesity was only significant in obese non-diabetic patients [OR (95% CI)=3.74 (1.43-9.74), p=0.007]. Additionally, obese male patients carrying the Ala-allele had significantly higher body mass index (p=0.007) and plasma leptin levels (p=0.023) compared to those homozygous for Pro-allele. The significant effect of Pro12Ala polymorphism on plasma leptin levels disappeared after adjustment for age and BMI.

CONCLUSION

The present study provides evidence that the Pro12Ala polymorphism of the PPARgamma-2 gene is associated with obesity in non-diabetic men from Tunisian origin.

Authors+Show Affiliations

Research Laboratory LR99ES11, Biochemistry Department, Rabta University Hospital, Tunis, Tunisia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19733160

Citation

Ben Ali, Samir, et al. "Gender-specific Effect of Pro12Ala Polymorphism in Peroxisome Proliferator-activated Receptor Gamma-2 Gene On Obesity Risk and Leptin Levels in a Tunisian Population." Clinical Biochemistry, vol. 42, no. 16-17, 2009, pp. 1642-7.
Ben Ali S, Ben Yahia F, Sediri Y, et al. Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. Clin Biochem. 2009;42(16-17):1642-7.
Ben Ali, S., Ben Yahia, F., Sediri, Y., Kallel, A., Ftouhi, B., Feki, M., Elasmi, M., Haj-Taieb, S., Souheil, O., Sanhagi, H., Slimane, H., Jemaa, R., & Kaabachi, N. (2009). Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. Clinical Biochemistry, 42(16-17), 1642-7. https://doi.org/10.1016/j.clinbiochem.2009.08.019
Ben Ali S, et al. Gender-specific Effect of Pro12Ala Polymorphism in Peroxisome Proliferator-activated Receptor Gamma-2 Gene On Obesity Risk and Leptin Levels in a Tunisian Population. Clin Biochem. 2009;42(16-17):1642-7. PubMed PMID: 19733160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. AU - Ben Ali,Samir, AU - Ben Yahia,Fatma, AU - Sediri,Yousra, AU - Kallel,Amani, AU - Ftouhi,Bochra, AU - Feki,Moncef, AU - Elasmi,Monia, AU - Haj-Taieb,Sameh, AU - Souheil,Omar, AU - Sanhagi,Haifa, AU - Slimane,Hedia, AU - Jemaa,Riadh, AU - Kaabachi,Naziha, Y1 - 2009/09/03/ PY - 2009/05/23/received PY - 2009/08/12/revised PY - 2009/08/27/accepted PY - 2009/9/8/entrez PY - 2009/9/8/pubmed PY - 2009/12/16/medline SP - 1642 EP - 7 JF - Clinical biochemistry JO - Clin Biochem VL - 42 IS - 16-17 N2 - OBJECTIVES: This study was undertaken to investigate the impact of the Pro12Ala (rs1801282) polymorphism of the peroxisome proliferator-activated receptor gamma-2 (PPARgamma-2) gene on obesity or body mass index (BMI) and plasma leptin, insulin, adiponectin and lipid levels in a sample of the Tunisian population. DESIGN AND METHODS: The study included 387 obese patients and 288 control subjects. The Pro12Ala genotype was determined by polymerase chain reaction followed by a digestion with the restriction of endonuclease BstUI. RESULTS: In the whole population, there is no significant difference in genotype frequencies of the Pro12Ala polymorphism between obese patients and controls. However, separate analysis by gender revealed that obese men (but not women) had significantly higher frequency of Pro/Ala genotypes compared to controls (12.2% vs. 4.1%; chi(2)=6.76, p=0.009). In comparison to Pro/Pro homozygotes, Ala-allele bearers had a significantly higher risk of obesity [OR (95% CI)=3.26 (1.28-8.33)]. When obese subjects were stratified according to type 2 diabetes status, the association with obesity was only significant in obese non-diabetic patients [OR (95% CI)=3.74 (1.43-9.74), p=0.007]. Additionally, obese male patients carrying the Ala-allele had significantly higher body mass index (p=0.007) and plasma leptin levels (p=0.023) compared to those homozygous for Pro-allele. The significant effect of Pro12Ala polymorphism on plasma leptin levels disappeared after adjustment for age and BMI. CONCLUSION: The present study provides evidence that the Pro12Ala polymorphism of the PPARgamma-2 gene is associated with obesity in non-diabetic men from Tunisian origin. SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/19733160/Gender_specific_effect_of_Pro12Ala_polymorphism_in_peroxisome_proliferator_activated_receptor_gamma_2_gene_on_obesity_risk_and_leptin_levels_in_a_Tunisian_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(09)00375-0 DB - PRIME DP - Unbound Medicine ER -