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Elevated testosterone and hypergonadotropism in active adolescents of normal weight with oligomenorrhea.
J Pediatr Adolesc Gynecol. 2009 Oct; 22(5):323-7.JP

Abstract

STUDY OBJECTIVE

Oligomenorrhea in active adolescent females of normal weight is presumed to be related to hypoestrogenism secondary to physical activity and decreased fat mass. We hypothesized that active adolescents with oligomenorrhea would have lower estrogen levels than normal controls with similar levels of cardiovascular fitness.

DESIGN/PARTICIPANTS

Twenty healthy participants between the ages of 16 and 20 years were recruited at least 2 years postmenarche. Adolescents reporting fewer than 9 cycles a year (n = 6) were compared to 14 controls with monthly menstrual cycles. Histories of eating disorder, hirsutism, severe acne, depression, or amenorrhea were cause for exclusion.

MAIN OUTCOME MEASURES

Body composition and bone density were measured by total body dual x-ray absorpitometry. Cardiovascular fitness was evaluated by measuring oxygen consumption during exercise. Control subjects were matched by age, body mass index (BMI), and fitness level. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, progesterone, and estradiol were obtained. Statistical analysis was performed using SAS 9.1.

RESULTS

Cardiovascular fitness in both groups was within normal limits for age. No significant differences in BMI, estradiol concentrations, or bone density were found, but trunk fat mass was lower in adolescents with oligomenorrhea who also reported more frequent exercise. Testosterone concentrations and LH/FSH ratios were significantly higher in participants with irregular menstrual cycles (P = 0.0018 and <0.001, respectively).

CONCLUSION

Adolescents with oligomenorrhea were leaner, yet they had higher testosterone levels and a greater LH/FSH ratio than their BMI-matched, cyclic counterparts. We hypothesize that, in active adolescents of normal weight, elevated androgen and LH concentrations are linked to ovarian dysfunction, which can masquerade as exercise-induced oligomenorrhea.

Authors+Show Affiliations

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109-0718, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19733321

Citation

Singer, K, et al. "Elevated Testosterone and Hypergonadotropism in Active Adolescents of Normal Weight With Oligomenorrhea." Journal of Pediatric and Adolescent Gynecology, vol. 22, no. 5, 2009, pp. 323-7.
Singer K, Rosenthal A, Kasa-Vubu JZ. Elevated testosterone and hypergonadotropism in active adolescents of normal weight with oligomenorrhea. J Pediatr Adolesc Gynecol. 2009;22(5):323-7.
Singer, K., Rosenthal, A., & Kasa-Vubu, J. Z. (2009). Elevated testosterone and hypergonadotropism in active adolescents of normal weight with oligomenorrhea. Journal of Pediatric and Adolescent Gynecology, 22(5), 323-7. https://doi.org/10.1016/j.jpag.2008.12.010
Singer K, Rosenthal A, Kasa-Vubu JZ. Elevated Testosterone and Hypergonadotropism in Active Adolescents of Normal Weight With Oligomenorrhea. J Pediatr Adolesc Gynecol. 2009;22(5):323-7. PubMed PMID: 19733321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated testosterone and hypergonadotropism in active adolescents of normal weight with oligomenorrhea. AU - Singer,K, AU - Rosenthal,A, AU - Kasa-Vubu,Josephine Z, PY - 2008/11/17/received PY - 2008/12/18/revised PY - 2008/12/22/accepted PY - 2009/9/8/entrez PY - 2009/9/8/pubmed PY - 2009/12/23/medline SP - 323 EP - 7 JF - Journal of pediatric and adolescent gynecology JO - J Pediatr Adolesc Gynecol VL - 22 IS - 5 N2 - STUDY OBJECTIVE: Oligomenorrhea in active adolescent females of normal weight is presumed to be related to hypoestrogenism secondary to physical activity and decreased fat mass. We hypothesized that active adolescents with oligomenorrhea would have lower estrogen levels than normal controls with similar levels of cardiovascular fitness. DESIGN/PARTICIPANTS: Twenty healthy participants between the ages of 16 and 20 years were recruited at least 2 years postmenarche. Adolescents reporting fewer than 9 cycles a year (n = 6) were compared to 14 controls with monthly menstrual cycles. Histories of eating disorder, hirsutism, severe acne, depression, or amenorrhea were cause for exclusion. MAIN OUTCOME MEASURES: Body composition and bone density were measured by total body dual x-ray absorpitometry. Cardiovascular fitness was evaluated by measuring oxygen consumption during exercise. Control subjects were matched by age, body mass index (BMI), and fitness level. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, progesterone, and estradiol were obtained. Statistical analysis was performed using SAS 9.1. RESULTS: Cardiovascular fitness in both groups was within normal limits for age. No significant differences in BMI, estradiol concentrations, or bone density were found, but trunk fat mass was lower in adolescents with oligomenorrhea who also reported more frequent exercise. Testosterone concentrations and LH/FSH ratios were significantly higher in participants with irregular menstrual cycles (P = 0.0018 and <0.001, respectively). CONCLUSION: Adolescents with oligomenorrhea were leaner, yet they had higher testosterone levels and a greater LH/FSH ratio than their BMI-matched, cyclic counterparts. We hypothesize that, in active adolescents of normal weight, elevated androgen and LH concentrations are linked to ovarian dysfunction, which can masquerade as exercise-induced oligomenorrhea. SN - 1873-4332 UR - https://www.unboundmedicine.com/medline/citation/19733321/Elevated_testosterone_and_hypergonadotropism_in_active_adolescents_of_normal_weight_with_oligomenorrhea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1083-3188(08)00347-1 DB - PRIME DP - Unbound Medicine ER -