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Increased low-density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease.
Clin Biochem. 2010 Feb; 43(3):267-71.CB

Abstract

OBJECTIVES

The two most common forms of dementia are Alzheimer's disease (AD), and vascular dementia (VaD). In the overlap of biochemical processes which have been identified in AD and VaD, oxidative stress is believed to contribute to the numerous pathologies of both dementias.

DESIGN AND METHODS

This study assessed oxidative damage in total plasma proteins, and isolated LDL in AD patients and age matched controls, in addition total antioxidant capacity (TAC) was measured.

RESULTS

Significantly higher LDL protein carbonylation was observed in AD compared to age-matched controls (AD: 4.17+/-0.73 vs. control: 3.85+/-0.86 nmol/mg LDL; p=0.05, 2-tailed Mann-Whitney), in addition to reduced TAC (AD: 924.708+/-174.429 vs. control: 1078.536+/-252.633 microM; p=0.001, 2-tailed Mann-Whitney). No differences were seen in total plasma protein carbonyl content (AD: 3.88+/-0.31 vs. control: 3.98+/-0.48 nmol/mg protein).

CONCLUSION

The results further support the view that oxidation events in AD may be specific in nature, and represent functional changes to proteins, rather than random global events.

Authors+Show Affiliations

School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. s.aldred.1@bham.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19733555

Citation

Aldred, Sarah, et al. "Increased Low-density Lipoprotein Oxidation, but Not Total Plasma Protein Oxidation, in Alzheimer's Disease." Clinical Biochemistry, vol. 43, no. 3, 2010, pp. 267-71.
Aldred S, Bennett S, Mecocci P. Increased low-density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease. Clin Biochem. 2010;43(3):267-71.
Aldred, S., Bennett, S., & Mecocci, P. (2010). Increased low-density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease. Clinical Biochemistry, 43(3), 267-71. https://doi.org/10.1016/j.clinbiochem.2009.08.021
Aldred S, Bennett S, Mecocci P. Increased Low-density Lipoprotein Oxidation, but Not Total Plasma Protein Oxidation, in Alzheimer's Disease. Clin Biochem. 2010;43(3):267-71. PubMed PMID: 19733555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased low-density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease. AU - Aldred,Sarah, AU - Bennett,Stuart, AU - Mecocci,Patrizia, Y1 - 2009/09/04/ PY - 2009/07/15/received PY - 2009/08/25/revised PY - 2009/08/27/accepted PY - 2009/9/8/entrez PY - 2009/9/8/pubmed PY - 2010/3/31/medline SP - 267 EP - 71 JF - Clinical biochemistry JO - Clin Biochem VL - 43 IS - 3 N2 - OBJECTIVES: The two most common forms of dementia are Alzheimer's disease (AD), and vascular dementia (VaD). In the overlap of biochemical processes which have been identified in AD and VaD, oxidative stress is believed to contribute to the numerous pathologies of both dementias. DESIGN AND METHODS: This study assessed oxidative damage in total plasma proteins, and isolated LDL in AD patients and age matched controls, in addition total antioxidant capacity (TAC) was measured. RESULTS: Significantly higher LDL protein carbonylation was observed in AD compared to age-matched controls (AD: 4.17+/-0.73 vs. control: 3.85+/-0.86 nmol/mg LDL; p=0.05, 2-tailed Mann-Whitney), in addition to reduced TAC (AD: 924.708+/-174.429 vs. control: 1078.536+/-252.633 microM; p=0.001, 2-tailed Mann-Whitney). No differences were seen in total plasma protein carbonyl content (AD: 3.88+/-0.31 vs. control: 3.98+/-0.48 nmol/mg protein). CONCLUSION: The results further support the view that oxidation events in AD may be specific in nature, and represent functional changes to proteins, rather than random global events. SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/19733555/Increased_low_density_lipoprotein_oxidation_but_not_total_plasma_protein_oxidation_in_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(09)00373-7 DB - PRIME DP - Unbound Medicine ER -