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Chemopreventive efficacy of piperine in 7,12-dimethyl benz [a] anthracene (DMBA)-induced hamster buccal pouch carcinogenesis: an FT-IR study.
Food Chem Toxicol. 2009 Nov; 47(11):2813-20.FC

Abstract

The present study is designed to investigate the effect of piperine in modifying the carcinogenic process, as well as biochemical alterations at the molecular level during DMBA-induced hamster buccal pouch carcinogenesis by FT-IR spectroscopy. Specific changes were noticed in the FT-IR spectral features of DMBA-induced hamster buccal pouch carcinoma. These alterations include structural changes of proteins and possible increase of its content, an increase in the nuclear-to-cytoplasm ratio, an increase in the relative amount of DNA, an enhancement in the phosphorylation of proteins, a loss of hydrogen bonding of the C-OH groups in the amino acid residues of proteins and diminished lipid peroxidation which were accompanied by a significant reduction in the relative amount of lipids compared to untreated control animals. Administration of piperine significantly increased the levels of lipid peroxidation and decreased the levels of proteins and nucleic acid content that were found to increase in oral cancer bearing animals. In conclusion, the results of the present study suggest that piperine may exert its chemopreventive effect by modulating the biochemical changes at the molecular level during DMBA-induced hamster buccal pouch carcinogenesis which can be detected using FT-IR spectroscopic technique.

Authors+Show Affiliations

Department of Physics, Annamalai University, Annamalainagar 608002, Tamilnadu, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19733613

Citation

Krishnakumar, N, et al. "Chemopreventive Efficacy of Piperine in 7,12-dimethyl Benz [a] Anthracene (DMBA)-induced Hamster Buccal Pouch Carcinogenesis: an FT-IR Study." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 11, 2009, pp. 2813-20.
Krishnakumar N, Manoharan S, Palaniappan PR, et al. Chemopreventive efficacy of piperine in 7,12-dimethyl benz [a] anthracene (DMBA)-induced hamster buccal pouch carcinogenesis: an FT-IR study. Food Chem Toxicol. 2009;47(11):2813-20.
Krishnakumar, N., Manoharan, S., Palaniappan, P. R., Venkatachalam, P., & Manohar, M. G. (2009). Chemopreventive efficacy of piperine in 7,12-dimethyl benz [a] anthracene (DMBA)-induced hamster buccal pouch carcinogenesis: an FT-IR study. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(11), 2813-20. https://doi.org/10.1016/j.fct.2009.08.017
Krishnakumar N, et al. Chemopreventive Efficacy of Piperine in 7,12-dimethyl Benz [a] Anthracene (DMBA)-induced Hamster Buccal Pouch Carcinogenesis: an FT-IR Study. Food Chem Toxicol. 2009;47(11):2813-20. PubMed PMID: 19733613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemopreventive efficacy of piperine in 7,12-dimethyl benz [a] anthracene (DMBA)-induced hamster buccal pouch carcinogenesis: an FT-IR study. AU - Krishnakumar,N, AU - Manoharan,S, AU - Palaniappan,Pl Rm, AU - Venkatachalam,P, AU - Manohar,M G Arun, Y1 - 2009/09/04/ PY - 2009/04/28/received PY - 2009/07/20/revised PY - 2009/08/31/accepted PY - 2009/9/8/entrez PY - 2009/9/8/pubmed PY - 2010/2/13/medline SP - 2813 EP - 20 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 11 N2 - The present study is designed to investigate the effect of piperine in modifying the carcinogenic process, as well as biochemical alterations at the molecular level during DMBA-induced hamster buccal pouch carcinogenesis by FT-IR spectroscopy. Specific changes were noticed in the FT-IR spectral features of DMBA-induced hamster buccal pouch carcinoma. These alterations include structural changes of proteins and possible increase of its content, an increase in the nuclear-to-cytoplasm ratio, an increase in the relative amount of DNA, an enhancement in the phosphorylation of proteins, a loss of hydrogen bonding of the C-OH groups in the amino acid residues of proteins and diminished lipid peroxidation which were accompanied by a significant reduction in the relative amount of lipids compared to untreated control animals. Administration of piperine significantly increased the levels of lipid peroxidation and decreased the levels of proteins and nucleic acid content that were found to increase in oral cancer bearing animals. In conclusion, the results of the present study suggest that piperine may exert its chemopreventive effect by modulating the biochemical changes at the molecular level during DMBA-induced hamster buccal pouch carcinogenesis which can be detected using FT-IR spectroscopic technique. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19733613/Chemopreventive_efficacy_of_piperine_in_712_dimethyl_benz_[a]_anthracene__DMBA__induced_hamster_buccal_pouch_carcinogenesis:_an_FT_IR_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00405-0 DB - PRIME DP - Unbound Medicine ER -