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Enhanced surface plasmon resonance by Au nanoparticles immobilized on a dielectric SiO2 layer on a gold surface.
Anal Chim Acta. 2009 Sep 28; 651(1):91-7.AC

Abstract

This paper introduces strategies for enhancement of a surface plasmon resonance (SPR) signal by adopting colloidal gold nanoparticles (AuNPs) and a SiO(2) layer on a gold surface. AuNPs on SiO(2) on a gold surface were compared with an unmodified gold surface and a SiO(2) layer on a gold surface with no AuNPs attached. The modified surfaces showed significant changes in SPR signal when biomolecules were attached to the surface as compared with an unmodified gold surface. The detection limit of AuNPs immobilized on a SPR chip was 0.1 ng mL(-1) for the prostate-specific antigen (PSA), a cancer marker, as measured with a spectrophotometer. Considering that the conventional ELISA method can detect approximately 10 ng mL(-1) of PSA, the strategy described here is much more sensitive (approximately 100 fold). The enhanced shift of the absorption curve resulted from the coupling of the surface and particle plasmons by the SiO(2) layer and the AuNPs on the gold surface.

Authors+Show Affiliations

Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul 151-742, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19733741

Citation

Jung, Jaeyeon, et al. "Enhanced Surface Plasmon Resonance By Au Nanoparticles Immobilized On a Dielectric SiO2 Layer On a Gold Surface." Analytica Chimica Acta, vol. 651, no. 1, 2009, pp. 91-7.
Jung J, Na K, Lee J, et al. Enhanced surface plasmon resonance by Au nanoparticles immobilized on a dielectric SiO2 layer on a gold surface. Anal Chim Acta. 2009;651(1):91-7.
Jung, J., Na, K., Lee, J., Kim, K. W., & Hyun, J. (2009). Enhanced surface plasmon resonance by Au nanoparticles immobilized on a dielectric SiO2 layer on a gold surface. Analytica Chimica Acta, 651(1), 91-7. https://doi.org/10.1016/j.aca.2009.07.057
Jung J, et al. Enhanced Surface Plasmon Resonance By Au Nanoparticles Immobilized On a Dielectric SiO2 Layer On a Gold Surface. Anal Chim Acta. 2009 Sep 28;651(1):91-7. PubMed PMID: 19733741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced surface plasmon resonance by Au nanoparticles immobilized on a dielectric SiO2 layer on a gold surface. AU - Jung,Jaeyeon, AU - Na,Kyunga, AU - Lee,Jonghwan, AU - Kim,Ki-Woo, AU - Hyun,Jinho, Y1 - 2009/07/29/ PY - 2009/03/31/received PY - 2009/07/22/revised PY - 2009/07/23/accepted PY - 2009/9/8/entrez PY - 2009/9/8/pubmed PY - 2009/12/18/medline SP - 91 EP - 7 JF - Analytica chimica acta JO - Anal Chim Acta VL - 651 IS - 1 N2 - This paper introduces strategies for enhancement of a surface plasmon resonance (SPR) signal by adopting colloidal gold nanoparticles (AuNPs) and a SiO(2) layer on a gold surface. AuNPs on SiO(2) on a gold surface were compared with an unmodified gold surface and a SiO(2) layer on a gold surface with no AuNPs attached. The modified surfaces showed significant changes in SPR signal when biomolecules were attached to the surface as compared with an unmodified gold surface. The detection limit of AuNPs immobilized on a SPR chip was 0.1 ng mL(-1) for the prostate-specific antigen (PSA), a cancer marker, as measured with a spectrophotometer. Considering that the conventional ELISA method can detect approximately 10 ng mL(-1) of PSA, the strategy described here is much more sensitive (approximately 100 fold). The enhanced shift of the absorption curve resulted from the coupling of the surface and particle plasmons by the SiO(2) layer and the AuNPs on the gold surface. SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/19733741/Enhanced_surface_plasmon_resonance_by_Au_nanoparticles_immobilized_on_a_dielectric_SiO2_layer_on_a_gold_surface_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(09)01013-7 DB - PRIME DP - Unbound Medicine ER -