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Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing.
J Allergy Clin Immunol. 2009 Oct; 124(4):707-13.e2.JA

Abstract

BACKGROUND

It has been proposed that immune dysfunction during early childhood plays an important role in asthma pathogenesis. However, it is not known specifically whether changes in dendritic cells (DCs) during infancy antedate the development of respiratory tract infections, asthma, and related clinical phenotypes.

OBJECTIVES

We sought to assess the association between the level of blood DCs during the first year and the subsequent development of respiratory tract infections, wheezing, and allergic sensitization.

METHODS

A community-based cohort of children with a family history of atopy was followed to age 5 years. Children were monitored intensively for respiratory tract infections. History of wheeze and asthma was collected annually, atopy was documented at 5 years, and flow cytometry was used to identify DC subsets in blood samples collected when children were well.

RESULTS

Levels of plasmacytoid DCs (pDCs) during infancy were inversely correlated with symptoms of lower respiratory tract infections, parent-reported wheezing, and the cumulative rate of physician-diagnosed asthma up to age 5 years. These relationships were independent of atopy, as determined by allergy skin test results and total and specific IgE levels. In contrast, levels of myeloid DCs were not associated with respiratory tract infections, asthma, or wheezing but were associated with total IgE levels at age 5 years.

CONCLUSION

In children with a family history of atopy, relative deficiency of circulating pDCs during infancy appears to be a risk factor for more frequent and more severe respiratory tract infections, wheezing, and a diagnosis of asthma. Infants with higher numbers of pDCs are protected against these outcomes.

Authors+Show Affiliations

Telethon Institute for Child Health Research, West Perth, and Centre for Child Health Research, University of Western Australia, Perth, Australia. j.upham@uq.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19733903

Citation

Upham, John W., et al. "Plasmacytoid Dendritic Cells During Infancy Are Inversely Associated With Childhood Respiratory Tract Infections and Wheezing." The Journal of Allergy and Clinical Immunology, vol. 124, no. 4, 2009, pp. 707-13.e2.
Upham JW, Zhang G, Rate A, et al. Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing. J Allergy Clin Immunol. 2009;124(4):707-13.e2.
Upham, J. W., Zhang, G., Rate, A., Yerkovich, S. T., Kusel, M., Sly, P. D., & Holt, P. G. (2009). Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing. The Journal of Allergy and Clinical Immunology, 124(4), 707-e2. https://doi.org/10.1016/j.jaci.2009.07.009
Upham JW, et al. Plasmacytoid Dendritic Cells During Infancy Are Inversely Associated With Childhood Respiratory Tract Infections and Wheezing. J Allergy Clin Immunol. 2009;124(4):707-13.e2. PubMed PMID: 19733903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing. AU - Upham,John W, AU - Zhang,Guicheng, AU - Rate,Angela, AU - Yerkovich,Stephanie T, AU - Kusel,Merci, AU - Sly,Peter D, AU - Holt,Patrick G, Y1 - 2009/09/06/ PY - 2009/04/23/received PY - 2009/06/25/revised PY - 2009/07/09/accepted PY - 2009/9/8/entrez PY - 2009/9/8/pubmed PY - 2009/11/17/medline SP - 707 EP - 13.e2 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 124 IS - 4 N2 - BACKGROUND: It has been proposed that immune dysfunction during early childhood plays an important role in asthma pathogenesis. However, it is not known specifically whether changes in dendritic cells (DCs) during infancy antedate the development of respiratory tract infections, asthma, and related clinical phenotypes. OBJECTIVES: We sought to assess the association between the level of blood DCs during the first year and the subsequent development of respiratory tract infections, wheezing, and allergic sensitization. METHODS: A community-based cohort of children with a family history of atopy was followed to age 5 years. Children were monitored intensively for respiratory tract infections. History of wheeze and asthma was collected annually, atopy was documented at 5 years, and flow cytometry was used to identify DC subsets in blood samples collected when children were well. RESULTS: Levels of plasmacytoid DCs (pDCs) during infancy were inversely correlated with symptoms of lower respiratory tract infections, parent-reported wheezing, and the cumulative rate of physician-diagnosed asthma up to age 5 years. These relationships were independent of atopy, as determined by allergy skin test results and total and specific IgE levels. In contrast, levels of myeloid DCs were not associated with respiratory tract infections, asthma, or wheezing but were associated with total IgE levels at age 5 years. CONCLUSION: In children with a family history of atopy, relative deficiency of circulating pDCs during infancy appears to be a risk factor for more frequent and more severe respiratory tract infections, wheezing, and a diagnosis of asthma. Infants with higher numbers of pDCs are protected against these outcomes. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/19733903/Plasmacytoid_dendritic_cells_during_infancy_are_inversely_associated_with_childhood_respiratory_tract_infections_and_wheezing_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(09)01014-8 DB - PRIME DP - Unbound Medicine ER -