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The Danish PEP registry: experience with the use of postexposure prophylaxis (PEP) following sexual exposure to HIV from 1998 to 2006.
Sex Transm Dis. 2010 Jan; 37(1):49-52.ST

Abstract

BACKGROUND

Studies indicate that antiretroviral postexposure prophylaxis (PEP) after sexual exposure to HIV reduce the risk of infection considerably. Since 1998 PEP after sexual HIV exposure within the preceding 24 hours, has been available in Denmark. PEP can only be prescribed at clinical centers with specialists experienced in HIV treatment. The objective of this study is to describe the use of PEP after sexual exposure from 1998 to 2006.

METHODS

The Danish PEP registry collects data from all cases of PEP use in Denmark after exposure to HIV through a structured questionnaire.

RESULTS

There were 374 cases of PEP use after sexual exposure. The incidence increased from 5 cases in 1997 to 87 in 2006. PEP was used by heterosexuals (40%) as well as men who have sex with men (57%). The HIV-status of the source was unknown in 41% of the cases of which 90% involved a source belonging to a high risk group, and 63% involved exposure by receptive anal intercourse. PEP was administered within 24 hours in 95% of the cases and the median time to initiation (N = 225) was 11.0 hours (range 0.5-60.0). PEP was completed by 65%.

CONCLUSIONS

This nationwide study showed a steady but moderate increase in the use of PEP after sexual HIV-exposure from 1998 to 2006. Time to initiation of PEP was low and the PEP prescription practice was targeted toward high risk exposures.

Authors+Show Affiliations

Department of Infectious Diseases, Helsingor Hospital, Helsingor, Denmark. lunding@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19734819

Citation

Lunding, Suzanne, et al. "The Danish PEP Registry: Experience With the Use of Postexposure Prophylaxis (PEP) Following Sexual Exposure to HIV From 1998 to 2006." Sexually Transmitted Diseases, vol. 37, no. 1, 2010, pp. 49-52.
Lunding S, Katzenstein TL, Kronborg G, et al. The Danish PEP registry: experience with the use of postexposure prophylaxis (PEP) following sexual exposure to HIV from 1998 to 2006. Sex Transm Dis. 2010;37(1):49-52.
Lunding, S., Katzenstein, T. L., Kronborg, G., Lindberg, J. A., Jensen, J., Nielsen, H. I., Pedersen, C., & Jørgensen, L. B. (2010). The Danish PEP registry: experience with the use of postexposure prophylaxis (PEP) following sexual exposure to HIV from 1998 to 2006. Sexually Transmitted Diseases, 37(1), 49-52. https://doi.org/10.1097/OLQ.0b013e3181b6f284
Lunding S, et al. The Danish PEP Registry: Experience With the Use of Postexposure Prophylaxis (PEP) Following Sexual Exposure to HIV From 1998 to 2006. Sex Transm Dis. 2010;37(1):49-52. PubMed PMID: 19734819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Danish PEP registry: experience with the use of postexposure prophylaxis (PEP) following sexual exposure to HIV from 1998 to 2006. AU - Lunding,Suzanne, AU - Katzenstein,Terese L, AU - Kronborg,Gitte, AU - Lindberg,Jens A, AU - Jensen,Janne, AU - Nielsen,Henrik I, AU - Pedersen,Court, AU - Jørgensen,Louise B, PY - 2009/9/8/entrez PY - 2009/9/8/pubmed PY - 2010/4/21/medline SP - 49 EP - 52 JF - Sexually transmitted diseases JO - Sex Transm Dis VL - 37 IS - 1 N2 - BACKGROUND: Studies indicate that antiretroviral postexposure prophylaxis (PEP) after sexual exposure to HIV reduce the risk of infection considerably. Since 1998 PEP after sexual HIV exposure within the preceding 24 hours, has been available in Denmark. PEP can only be prescribed at clinical centers with specialists experienced in HIV treatment. The objective of this study is to describe the use of PEP after sexual exposure from 1998 to 2006. METHODS: The Danish PEP registry collects data from all cases of PEP use in Denmark after exposure to HIV through a structured questionnaire. RESULTS: There were 374 cases of PEP use after sexual exposure. The incidence increased from 5 cases in 1997 to 87 in 2006. PEP was used by heterosexuals (40%) as well as men who have sex with men (57%). The HIV-status of the source was unknown in 41% of the cases of which 90% involved a source belonging to a high risk group, and 63% involved exposure by receptive anal intercourse. PEP was administered within 24 hours in 95% of the cases and the median time to initiation (N = 225) was 11.0 hours (range 0.5-60.0). PEP was completed by 65%. CONCLUSIONS: This nationwide study showed a steady but moderate increase in the use of PEP after sexual HIV-exposure from 1998 to 2006. Time to initiation of PEP was low and the PEP prescription practice was targeted toward high risk exposures. SN - 1537-4521 UR - https://www.unboundmedicine.com/medline/citation/19734819/The_Danish_PEP_registry:_experience_with_the_use_of_postexposure_prophylaxis__PEP__following_sexual_exposure_to_HIV_from_1998_to_2006_ L2 - https://doi.org/10.1097/OLQ.0b013e3181b6f284 DB - PRIME DP - Unbound Medicine ER -