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Toxic effects of lambda-cyhalothrin, a synthetic pyrethroid pesticide, on the rat kidney: Involvement of oxidative stress and protective role of ascorbic acid.
Exp Toxicol Pathol. 2010 Nov; 62(6):593-9.ET

Abstract

Lambda-cyhalothrin is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control, protection of foodstuff and disease vector control. The objective of this study was to investigate the propensity of lambda-cyhalothrin (LTC) to induce oxidative stress, changes in biochemical parameters and enzyme activities in the kidney of male rats and its possible attenuation by Vitamin C (vit C). Renal function, histopathology, tissue malondialdehyde (MDA), protein carbonyl (PCO) levels, antioxidant enzyme activities and reduced glutathione (GSH) levels were evaluated. Exposure of rats to lambda-cyhalothrin, during 3 weeks, caused a significant increase in kidney MDA and protein carbonyl levels (p<0.01) as compared to controls. Co-administration of vitamin C was effective in reducing MDA and PCO levels. The kidney of LTC-treated rats exhibited severe vacuolations, cells infiltration and widened tubular lumen. The activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) were significantly decreased due to lambda-cyhalothrin exposure. Co-administration of vitamin C ameliorated the increase in enzymatic activities of aminotransferases (AST and ALT), lactate dehydrogenase (LDH), creatinine and urea levels and improved the antioxidant status. These data indicated the protective role of ascorbic acid against lambda-cyhalothrin-induced nephrotoxicity and suggested a significant contribution of its antioxidant property to these beneficial effects.

Authors+Show Affiliations

Animal Physiology Laboratory, Life Science Department, Sciences Faculty of Sfax, Sfax, Tunisia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19735994

Citation

Fetoui, Hamadi, et al. "Toxic Effects of Lambda-cyhalothrin, a Synthetic Pyrethroid Pesticide, On the Rat Kidney: Involvement of Oxidative Stress and Protective Role of Ascorbic Acid." Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, vol. 62, no. 6, 2010, pp. 593-9.
Fetoui H, Makni M, Garoui el M, et al. Toxic effects of lambda-cyhalothrin, a synthetic pyrethroid pesticide, on the rat kidney: Involvement of oxidative stress and protective role of ascorbic acid. Exp Toxicol Pathol. 2010;62(6):593-9.
Fetoui, H., Makni, M., Garoui, e. l. . M., & Zeghal, N. (2010). Toxic effects of lambda-cyhalothrin, a synthetic pyrethroid pesticide, on the rat kidney: Involvement of oxidative stress and protective role of ascorbic acid. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, 62(6), 593-9. https://doi.org/10.1016/j.etp.2009.08.004
Fetoui H, et al. Toxic Effects of Lambda-cyhalothrin, a Synthetic Pyrethroid Pesticide, On the Rat Kidney: Involvement of Oxidative Stress and Protective Role of Ascorbic Acid. Exp Toxicol Pathol. 2010;62(6):593-9. PubMed PMID: 19735994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxic effects of lambda-cyhalothrin, a synthetic pyrethroid pesticide, on the rat kidney: Involvement of oxidative stress and protective role of ascorbic acid. AU - Fetoui,Hamadi, AU - Makni,Mohamed, AU - Garoui,El Mouldi, AU - Zeghal,Najiba, Y1 - 2009/09/06/ PY - 2009/06/19/received PY - 2009/07/24/revised PY - 2009/08/10/accepted PY - 2009/9/9/entrez PY - 2009/9/9/pubmed PY - 2011/3/5/medline SP - 593 EP - 9 JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie JO - Exp. Toxicol. Pathol. VL - 62 IS - 6 N2 - Lambda-cyhalothrin is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control, protection of foodstuff and disease vector control. The objective of this study was to investigate the propensity of lambda-cyhalothrin (LTC) to induce oxidative stress, changes in biochemical parameters and enzyme activities in the kidney of male rats and its possible attenuation by Vitamin C (vit C). Renal function, histopathology, tissue malondialdehyde (MDA), protein carbonyl (PCO) levels, antioxidant enzyme activities and reduced glutathione (GSH) levels were evaluated. Exposure of rats to lambda-cyhalothrin, during 3 weeks, caused a significant increase in kidney MDA and protein carbonyl levels (p<0.01) as compared to controls. Co-administration of vitamin C was effective in reducing MDA and PCO levels. The kidney of LTC-treated rats exhibited severe vacuolations, cells infiltration and widened tubular lumen. The activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) were significantly decreased due to lambda-cyhalothrin exposure. Co-administration of vitamin C ameliorated the increase in enzymatic activities of aminotransferases (AST and ALT), lactate dehydrogenase (LDH), creatinine and urea levels and improved the antioxidant status. These data indicated the protective role of ascorbic acid against lambda-cyhalothrin-induced nephrotoxicity and suggested a significant contribution of its antioxidant property to these beneficial effects. SN - 1618-1433 UR - https://www.unboundmedicine.com/medline/citation/19735994/Toxic_effects_of_lambda_cyhalothrin_a_synthetic_pyrethroid_pesticide_on_the_rat_kidney:_Involvement_of_oxidative_stress_and_protective_role_of_ascorbic_acid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0940-2993(09)00232-2 DB - PRIME DP - Unbound Medicine ER -