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Lung function and indicators of exposure to indoor and outdoor particulate matter among asthma and COPD patients.
Occup Environ Med. 2010 Jan; 67(1):2-10.OE

Abstract

OBJECTIVES

Misclassification of exposure related to the use of central sites may be larger for ultrafine particles than for particulate matter < or =2.5 microm and < or =10 microm (PM(2.5) and PM(10)) and may result in underestimation of health effects. This paper describes the relative strength of the association between outdoor and indoor exposure to ultrafine particles, PM(2.5) and PM(10) and lung function.

METHODS

In four European cities (Helsinki, Athens, Amsterdam and Birmingham), lung function (forced vital capacity (FVC), forced expiratory volume in 1 second (FEV(1)) and peak expiratory flow (PEF)) was measured three times a day for 1 week in 135 patients with asthma or chronic obstructive pulmonary disease (COPD), covering study periods of >1 year. Daily concentrations of particle number, PM(2.5) and PM(10) were measured at a central site in each city and both inside and outside the subjects' homes.

RESULTS

Daily average particle number concentrations ranged between 2100 and 66 100 particles/cm(3). We found no association between 24 h average particle number or particle mass concentrations and FVC, FEV(1) and PEF. Substituting home outdoor or home indoor concentrations of particulate air pollution instead of the central site measurements did not change the observed associations. Analyses restricted to asthmatics also showed no associations.

CONCLUSIONS

No consistent associations between lung function and 24 h average particle number or particle mass concentrations were found in panels of patients with mild to moderate COPD or asthma. More detailed exposure assessment did not change the observed associations. The lack of association could be due to the high prevalence of medication use, limited ability to assess lagged effects over several days or absence of an effect.

Authors+Show Affiliations

IRAS, Utrecht University, PO Box 80178, 3508 TD Utrecht, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19736175

Citation

de Hartog, J J., et al. "Lung Function and Indicators of Exposure to Indoor and Outdoor Particulate Matter Among Asthma and COPD Patients." Occupational and Environmental Medicine, vol. 67, no. 1, 2010, pp. 2-10.
de Hartog JJ, Ayres JG, Karakatsani A, et al. Lung function and indicators of exposure to indoor and outdoor particulate matter among asthma and COPD patients. Occup Environ Med. 2010;67(1):2-10.
de Hartog, J. J., Ayres, J. G., Karakatsani, A., Analitis, A., Brink, H. T., Hameri, K., Harrison, R., Katsouyanni, K., Kotronarou, A., Kavouras, I., Meddings, C., Pekkanen, J., & Hoek, G. (2010). Lung function and indicators of exposure to indoor and outdoor particulate matter among asthma and COPD patients. Occupational and Environmental Medicine, 67(1), 2-10. https://doi.org/10.1136/oem.2008.040857
de Hartog JJ, et al. Lung Function and Indicators of Exposure to Indoor and Outdoor Particulate Matter Among Asthma and COPD Patients. Occup Environ Med. 2010;67(1):2-10. PubMed PMID: 19736175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lung function and indicators of exposure to indoor and outdoor particulate matter among asthma and COPD patients. AU - de Hartog,J J, AU - Ayres,J G, AU - Karakatsani,A, AU - Analitis,A, AU - Brink,H Ten, AU - Hameri,K, AU - Harrison,R, AU - Katsouyanni,K, AU - Kotronarou,A, AU - Kavouras,I, AU - Meddings,C, AU - Pekkanen,J, AU - Hoek,G, Y1 - 2009/09/06/ PY - 2009/9/9/entrez PY - 2009/9/9/pubmed PY - 2010/2/26/medline SP - 2 EP - 10 JF - Occupational and environmental medicine JO - Occup Environ Med VL - 67 IS - 1 N2 - OBJECTIVES: Misclassification of exposure related to the use of central sites may be larger for ultrafine particles than for particulate matter < or =2.5 microm and < or =10 microm (PM(2.5) and PM(10)) and may result in underestimation of health effects. This paper describes the relative strength of the association between outdoor and indoor exposure to ultrafine particles, PM(2.5) and PM(10) and lung function. METHODS: In four European cities (Helsinki, Athens, Amsterdam and Birmingham), lung function (forced vital capacity (FVC), forced expiratory volume in 1 second (FEV(1)) and peak expiratory flow (PEF)) was measured three times a day for 1 week in 135 patients with asthma or chronic obstructive pulmonary disease (COPD), covering study periods of >1 year. Daily concentrations of particle number, PM(2.5) and PM(10) were measured at a central site in each city and both inside and outside the subjects' homes. RESULTS: Daily average particle number concentrations ranged between 2100 and 66 100 particles/cm(3). We found no association between 24 h average particle number or particle mass concentrations and FVC, FEV(1) and PEF. Substituting home outdoor or home indoor concentrations of particulate air pollution instead of the central site measurements did not change the observed associations. Analyses restricted to asthmatics also showed no associations. CONCLUSIONS: No consistent associations between lung function and 24 h average particle number or particle mass concentrations were found in panels of patients with mild to moderate COPD or asthma. More detailed exposure assessment did not change the observed associations. The lack of association could be due to the high prevalence of medication use, limited ability to assess lagged effects over several days or absence of an effect. SN - 1470-7926 UR - https://www.unboundmedicine.com/medline/citation/19736175/Lung_function_and_indicators_of_exposure_to_indoor_and_outdoor_particulate_matter_among_asthma_and_COPD_patients_ L2 - https://oem.bmj.com/lookup/pmidlookup?view=long&amp;pmid=19736175 DB - PRIME DP - Unbound Medicine ER -