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Illicit drugs in the environment.
Philos Trans A Math Phys Eng Sci 2009; 367(1904):3965-78PT

Abstract

This paper reviews the current state of knowledge on illicit drugs as emerging environmental contaminants. Several studies have recently reported that illicit drugs are detectable in wastewater from municipal sewage treatment plants (STPs) and surface waters. These substances are excreted in urine and faeces unchanged or as active metabolites in high percentages after consumption and continuously discharged into domestic wastewaters. Residues of illicit drugs can therefore reach STPs in substantial amounts, escaping degradation, and are then released into surface waters. Environmental concentrations are low, but risks for human health and the environment cannot be excluded. Morphine, cocaine, methamphetamine and ecstasy all have potent pharmacological activities, and their presence as complex mixtures in surface waters may be toxic to aquatic organisms. Levels of residues in untreated wastewater have been used to estimate illicit drug consumption in the population. Given that current epidemiological methods are indirect and possibly biased, this evidence-based approach offers a new tool for estimating drug abuse in real time.

Authors+Show Affiliations

Department of Environmental Health Sciences, Mario Negri Institute for Pharmacological Research, , Via La Masa 19, 20156 Milan, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19736230

Citation

Zuccato, Ettore, and Sara Castiglioni. "Illicit Drugs in the Environment." Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences, vol. 367, no. 1904, 2009, pp. 3965-78.
Zuccato E, Castiglioni S. Illicit drugs in the environment. Philos Trans A Math Phys Eng Sci. 2009;367(1904):3965-78.
Zuccato, E., & Castiglioni, S. (2009). Illicit drugs in the environment. Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences, 367(1904), pp. 3965-78. doi:10.1098/rsta.2009.0107.
Zuccato E, Castiglioni S. Illicit Drugs in the Environment. Philos Trans A Math Phys Eng Sci. 2009 Oct 13;367(1904):3965-78. PubMed PMID: 19736230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Illicit drugs in the environment. AU - Zuccato,Ettore, AU - Castiglioni,Sara, PY - 2009/9/9/entrez PY - 2009/9/9/pubmed PY - 2009/11/10/medline SP - 3965 EP - 78 JF - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences JO - Philos Trans A Math Phys Eng Sci VL - 367 IS - 1904 N2 - This paper reviews the current state of knowledge on illicit drugs as emerging environmental contaminants. Several studies have recently reported that illicit drugs are detectable in wastewater from municipal sewage treatment plants (STPs) and surface waters. These substances are excreted in urine and faeces unchanged or as active metabolites in high percentages after consumption and continuously discharged into domestic wastewaters. Residues of illicit drugs can therefore reach STPs in substantial amounts, escaping degradation, and are then released into surface waters. Environmental concentrations are low, but risks for human health and the environment cannot be excluded. Morphine, cocaine, methamphetamine and ecstasy all have potent pharmacological activities, and their presence as complex mixtures in surface waters may be toxic to aquatic organisms. Levels of residues in untreated wastewater have been used to estimate illicit drug consumption in the population. Given that current epidemiological methods are indirect and possibly biased, this evidence-based approach offers a new tool for estimating drug abuse in real time. SN - 1364-503X UR - https://www.unboundmedicine.com/medline/citation/19736230/Illicit_drugs_in_the_environment_ L2 - https://royalsocietypublishing.org/doi/full/10.1098/rsta.2009.0107?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -