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Poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) nanoparticles: preparation, characterization, and application in doxorubicin delivery.
J Phys Chem B 2009; 113(39):12928-33JP

Abstract

Biodegradable poly(epsilon-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymer nanoparticles showed potential application in drug delivery systems. In this article, monodisperse poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) (PCL/PEG/PCL, PCEC) nanoparticles, approximately 40 nm, were prepared by solvent extraction method using acetone as the organic solvent. These PCL/PEG/PCL nanoparticles did not induce hemolysis in vitro and did not show toxicity in vitro or in vivo. The prepared PCL/PEG/PCL nanoparticles were employed to load doxorubicin by a pH-induced self-assembly method. In vitro release study indicated that doxorubicin release from nanoparticles at pH 5.5 was faster than that at pH 7.0. The encapsulation of doxorubicin in PCL/PEG/PCL nanoparticles enhanced the cytotoxicity of doxorubicin on a C-26 cell line in vitro. Meanwhile, compared with free doxorubicin, doxorubicin in nanoparticles could more efficiently treat mice bearing subcutaneous C-26 tumors. The doxorubicin-loaded PCL/PEG/PCL nanoparticles might be a novel doxorubicin formulation for cancer therapy.

Authors+Show Affiliations

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19736995

Citation

Gou, MaLing, et al. "Poly(epsilon-caprolactone)/poly(ethylene Glycol)/poly(epsilon-caprolactone) Nanoparticles: Preparation, Characterization, and Application in Doxorubicin Delivery." The Journal of Physical Chemistry. B, vol. 113, no. 39, 2009, pp. 12928-33.
Gou M, Zheng X, Men K, et al. Poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) nanoparticles: preparation, characterization, and application in doxorubicin delivery. J Phys Chem B. 2009;113(39):12928-33.
Gou, M., Zheng, X., Men, K., Zhang, J., Zheng, L., Wang, X., ... Qian, Z. (2009). Poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) nanoparticles: preparation, characterization, and application in doxorubicin delivery. The Journal of Physical Chemistry. B, 113(39), pp. 12928-33. doi:10.1021/jp905781g.
Gou M, et al. Poly(epsilon-caprolactone)/poly(ethylene Glycol)/poly(epsilon-caprolactone) Nanoparticles: Preparation, Characterization, and Application in Doxorubicin Delivery. J Phys Chem B. 2009 Oct 1;113(39):12928-33. PubMed PMID: 19736995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) nanoparticles: preparation, characterization, and application in doxorubicin delivery. AU - Gou,MaLing, AU - Zheng,XiuLing, AU - Men,Ke, AU - Zhang,Juan, AU - Zheng,Lan, AU - Wang,XiuHong, AU - Luo,Feng, AU - Zhao,YinLan, AU - Zhao,Xia, AU - Wei,YuQuan, AU - Qian,ZhiYong, PY - 2009/9/10/entrez PY - 2009/9/10/pubmed PY - 2010/2/13/medline SP - 12928 EP - 33 JF - The journal of physical chemistry. B JO - J Phys Chem B VL - 113 IS - 39 N2 - Biodegradable poly(epsilon-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymer nanoparticles showed potential application in drug delivery systems. In this article, monodisperse poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) (PCL/PEG/PCL, PCEC) nanoparticles, approximately 40 nm, were prepared by solvent extraction method using acetone as the organic solvent. These PCL/PEG/PCL nanoparticles did not induce hemolysis in vitro and did not show toxicity in vitro or in vivo. The prepared PCL/PEG/PCL nanoparticles were employed to load doxorubicin by a pH-induced self-assembly method. In vitro release study indicated that doxorubicin release from nanoparticles at pH 5.5 was faster than that at pH 7.0. The encapsulation of doxorubicin in PCL/PEG/PCL nanoparticles enhanced the cytotoxicity of doxorubicin on a C-26 cell line in vitro. Meanwhile, compared with free doxorubicin, doxorubicin in nanoparticles could more efficiently treat mice bearing subcutaneous C-26 tumors. The doxorubicin-loaded PCL/PEG/PCL nanoparticles might be a novel doxorubicin formulation for cancer therapy. SN - 1520-5207 UR - https://www.unboundmedicine.com/medline/citation/19736995/Poly_epsilon_caprolactone_/poly_ethylene_glycol_/poly_epsilon_caprolactone__nanoparticles:_preparation_characterization_and_application_in_doxorubicin_delivery_ L2 - https://dx.doi.org/10.1021/jp905781g DB - PRIME DP - Unbound Medicine ER -