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Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1.
Prostaglandins Other Lipid Mediat. 2009 Sep; 89(3-4):126-30.PO

Abstract

Inflammation is a defensive response to injury and infection, but excessive or inappropriate inflammation contributes to a range of acute and chronic human diseases. Clinical assessment of dietary supplementation of omega-3 polyunsaturated fatty acids (PUFA) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) indicate their beneficial impact on human diseases in which inflammation is suspected as a key component of the pathogenesis. Although the mechanism of EPA and DHA action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 PUFA-derived mediators including resolvins and protectins with potent anti-inflammatory and pro-resolving properties are produced. In this review, we provide an overview of the formation and actions of EPA-derived anti-inflammatory lipid mediator resolvin E1.

Authors+Show Affiliations

Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19737659

Citation

Seki, Hiroyuki, et al. "Omega-3 PUFA Derived Anti-inflammatory Lipid Mediator Resolvin E1." Prostaglandins & Other Lipid Mediators, vol. 89, no. 3-4, 2009, pp. 126-30.
Seki H, Tani Y, Arita M. Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1. Prostaglandins Other Lipid Mediat. 2009;89(3-4):126-30.
Seki, H., Tani, Y., & Arita, M. (2009). Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1. Prostaglandins & Other Lipid Mediators, 89(3-4), 126-30. https://doi.org/10.1016/j.prostaglandins.2009.03.002
Seki H, Tani Y, Arita M. Omega-3 PUFA Derived Anti-inflammatory Lipid Mediator Resolvin E1. Prostaglandins Other Lipid Mediat. 2009;89(3-4):126-30. PubMed PMID: 19737659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1. AU - Seki,Hiroyuki, AU - Tani,Yukako, AU - Arita,Makoto, Y1 - 2009/03/25/ PY - 2009/02/05/received PY - 2009/02/28/revised PY - 2009/03/14/accepted PY - 2009/9/10/entrez PY - 2009/9/10/pubmed PY - 2009/12/16/medline SP - 126 EP - 30 JF - Prostaglandins & other lipid mediators JO - Prostaglandins Other Lipid Mediat. VL - 89 IS - 3-4 N2 - Inflammation is a defensive response to injury and infection, but excessive or inappropriate inflammation contributes to a range of acute and chronic human diseases. Clinical assessment of dietary supplementation of omega-3 polyunsaturated fatty acids (PUFA) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) indicate their beneficial impact on human diseases in which inflammation is suspected as a key component of the pathogenesis. Although the mechanism of EPA and DHA action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 PUFA-derived mediators including resolvins and protectins with potent anti-inflammatory and pro-resolving properties are produced. In this review, we provide an overview of the formation and actions of EPA-derived anti-inflammatory lipid mediator resolvin E1. SN - 1098-8823 UR - https://www.unboundmedicine.com/medline/citation/19737659/Omega_3_PUFA_derived_anti_inflammatory_lipid_mediator_resolvin_E1_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1098-8823(09)00017-3 DB - PRIME DP - Unbound Medicine ER -