Tags

Type your tag names separated by a space and hit enter

Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6.
J Biomater Appl. 2010 Aug; 25(2):161-77.JB

Abstract

Sustained intestinal delivery of thiamine hydrochloride (Vitamin B(1); VB(1)) and pyridoxine hydrochloride (Vitamin B(6); VB(6)) seems to be a feasible alternative to existing therapy. The vitamins (VB(1)/VB(6)) intercalated in montmorillonite (MMT) and intercalated VB(1)/VB(6)-MMT hybrid is further used for synthesis of VB(1)/VB(6)-MMT-alginate nanocomposite beads by gelation method and in vitro release in the intestinal environment. The structure and surface morphology of the synthesized VB(1)/VB(6)-MMT hybrid, VB(1)/VB(6)-alginate and VB(1)/VB(6)-MMT-alginate nanocomposite beads were characterized by XRD, FT-IR, TGA and SEM. In vitro release experiments revealed that the VB(1)/VB(6) releases suddenly from VB(1)/VB(6)-MMT hybrid and is pH dependent. The controlled release of VB(1)/VB(6) from VB(1)/VB(6)-MMT-alginate nanocomposite beads was observed to be controlled as compared to their release from VB(1)/VB(6)-MMT hybrid and VB(1)/VB(6)-alginate beads.

Links

Publisher Full Text

Authors+Show Affiliations

Kevadiya BD
Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (Council of Scientific & Industrial Research CSIR), Gijubhai Badheka Marg, Bhavnagar 364 002, Gujarat, India.
Joshi GV
No affiliation info available
Patel HA
No affiliation info available
Ingole PG
No affiliation info available
Mody HM
No affiliation info available
Bajaj HC
No affiliation info available

MeSH

AlginatesBentoniteDrug CarriersGlucuronic AcidHexuronic AcidsHydrogen-Ion ConcentrationIn Vitro TechniquesMicroscopy, Electron, ScanningNanocompositesSpectroscopy, Fourier Transform InfraredThermogravimetryThiamineVitamin B 6X-Ray Diffraction

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19737810

Citation

Kevadiya, Bhavesh D., et al. "Montmorillonite-alginate Nanocomposites as a Drug Delivery System: Intercalation and in Vitro Release of Vitamin B1 and Vitamin B6." Journal of Biomaterials Applications, vol. 25, no. 2, 2010, pp. 161-77.
Kevadiya BD, Joshi GV, Patel HA, et al. Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6. J Biomater Appl. 2010;25(2):161-77.
Kevadiya, B. D., Joshi, G. V., Patel, H. A., Ingole, P. G., Mody, H. M., & Bajaj, H. C. (2010). Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6. Journal of Biomaterials Applications, 25(2), 161-77. https://doi.org/10.1177/0885328209344003
Kevadiya BD, et al. Montmorillonite-alginate Nanocomposites as a Drug Delivery System: Intercalation and in Vitro Release of Vitamin B1 and Vitamin B6. J Biomater Appl. 2010;25(2):161-77. PubMed PMID: 19737810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6. AU - Kevadiya,Bhavesh D, AU - Joshi,Ghanshyam V, AU - Patel,Hasmukh A, AU - Ingole,Pravin G, AU - Mody,Haresh M, AU - Bajaj,Hari C, Y1 - 2009/09/08/ PY - 2009/9/10/entrez PY - 2009/9/10/pubmed PY - 2010/12/14/medline SP - 161 EP - 77 JF - Journal of biomaterials applications JO - J Biomater Appl VL - 25 IS - 2 N2 - Sustained intestinal delivery of thiamine hydrochloride (Vitamin B(1); VB(1)) and pyridoxine hydrochloride (Vitamin B(6); VB(6)) seems to be a feasible alternative to existing therapy. The vitamins (VB(1)/VB(6)) intercalated in montmorillonite (MMT) and intercalated VB(1)/VB(6)-MMT hybrid is further used for synthesis of VB(1)/VB(6)-MMT-alginate nanocomposite beads by gelation method and in vitro release in the intestinal environment. The structure and surface morphology of the synthesized VB(1)/VB(6)-MMT hybrid, VB(1)/VB(6)-alginate and VB(1)/VB(6)-MMT-alginate nanocomposite beads were characterized by XRD, FT-IR, TGA and SEM. In vitro release experiments revealed that the VB(1)/VB(6) releases suddenly from VB(1)/VB(6)-MMT hybrid and is pH dependent. The controlled release of VB(1)/VB(6) from VB(1)/VB(6)-MMT-alginate nanocomposite beads was observed to be controlled as compared to their release from VB(1)/VB(6)-MMT hybrid and VB(1)/VB(6)-alginate beads. SN - 1530-8022 UR - https://www.unboundmedicine.com/medline/citation/19737810/Montmorillonite_alginate_nanocomposites_as_a_drug_delivery_system:_intercalation_and_in_vitro_release_of_vitamin_B1_and_vitamin_B6_ L2 - https://journals.sagepub.com/doi/10.1177/0885328209344003?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -