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Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study.
Hum Reprod. 2009 Dec; 24(12):3049-56.HR

Abstract

BACKGROUND

Using a 3-year nationwide population-based database, this study examines the risk of adverse pregnancy outcomes [lower birthweight, preterm gestation and babies small for gestational age (SGA)] in pregnant women with uterine leiomyoma.

METHODS

This study linked two data sets: Taiwan's birth certificate registry and its National Health Insurance Research Data set. A total of 5627 mothers with uterine leiomyoma and 28 135 unaffected mothers were included for analysis. After adjusting for mother and infant characteristics and monthly family income, log-binominal regression and multivariate regression analyses were conducted to examine the risks of preterm birth, SGA and lower birthweight among mothers with uterine leiomyoma and unaffected mothers.

RESULTS

Women with uterine leiomyoma had a significantly higher percentage of preterm births (10.98 versus 7.78%, P < 0.001) and SGA infants (19.00 versus 17.28%, P = 0.002) than unaffected mothers. The mean birthweights for mothers with and without uterine leiomyoma were 3083 and 3172 g, respectively (P < 0.001). Log-binominal regression models show that the adjusted risk ratios of preterm births and SGA infants for mothers with uterine leiomyoma were 1.32 (95% CI 1.19-1.46) and 1.16 (95% CI 1.08-1.26), respectively, compared with unaffected mothers. After finally adjusting for gestational age and other covariates, a multivariate regression analysis revealed that women with uterine leiomyoma had, on average, a 14.7 g lower birthweight than unaffected mothers (P = 0.022).

CONCLUSIONS

We concluded that after adjusting for potential confounders, women with uterine leiomyoma experience a small yet significant increased risk of preterm and SGA infants. We suggest that clinicians intensively monitor women with uterine leiomyoma during pregnancy.

Authors+Show Affiliations

School of Public Health, Taipei Medical University, Taipei, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19740897

Citation

Chen, Yi-Hua, et al. "Increased Risk of Preterm Births Among Women With Uterine Leiomyoma: a Nationwide Population-based Study." Human Reproduction (Oxford, England), vol. 24, no. 12, 2009, pp. 3049-56.
Chen YH, Lin HC, Chen SF, et al. Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study. Hum Reprod. 2009;24(12):3049-56.
Chen, Y. H., Lin, H. C., Chen, S. F., & Lin, H. C. (2009). Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study. Human Reproduction (Oxford, England), 24(12), 3049-56. https://doi.org/10.1093/humrep/dep320
Chen YH, et al. Increased Risk of Preterm Births Among Women With Uterine Leiomyoma: a Nationwide Population-based Study. Hum Reprod. 2009;24(12):3049-56. PubMed PMID: 19740897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study. AU - Chen,Yi-Hua, AU - Lin,Herng-Ching, AU - Chen,Shu-Fen, AU - Lin,Hsiu-Chen, Y1 - 2009/09/09/ PY - 2009/9/11/entrez PY - 2009/9/11/pubmed PY - 2010/2/13/medline SP - 3049 EP - 56 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 24 IS - 12 N2 - BACKGROUND: Using a 3-year nationwide population-based database, this study examines the risk of adverse pregnancy outcomes [lower birthweight, preterm gestation and babies small for gestational age (SGA)] in pregnant women with uterine leiomyoma. METHODS: This study linked two data sets: Taiwan's birth certificate registry and its National Health Insurance Research Data set. A total of 5627 mothers with uterine leiomyoma and 28 135 unaffected mothers were included for analysis. After adjusting for mother and infant characteristics and monthly family income, log-binominal regression and multivariate regression analyses were conducted to examine the risks of preterm birth, SGA and lower birthweight among mothers with uterine leiomyoma and unaffected mothers. RESULTS: Women with uterine leiomyoma had a significantly higher percentage of preterm births (10.98 versus 7.78%, P < 0.001) and SGA infants (19.00 versus 17.28%, P = 0.002) than unaffected mothers. The mean birthweights for mothers with and without uterine leiomyoma were 3083 and 3172 g, respectively (P < 0.001). Log-binominal regression models show that the adjusted risk ratios of preterm births and SGA infants for mothers with uterine leiomyoma were 1.32 (95% CI 1.19-1.46) and 1.16 (95% CI 1.08-1.26), respectively, compared with unaffected mothers. After finally adjusting for gestational age and other covariates, a multivariate regression analysis revealed that women with uterine leiomyoma had, on average, a 14.7 g lower birthweight than unaffected mothers (P = 0.022). CONCLUSIONS: We concluded that after adjusting for potential confounders, women with uterine leiomyoma experience a small yet significant increased risk of preterm and SGA infants. We suggest that clinicians intensively monitor women with uterine leiomyoma during pregnancy. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/19740897/Increased_risk_of_preterm_births_among_women_with_uterine_leiomyoma:_a_nationwide_population_based_study_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dep320 DB - PRIME DP - Unbound Medicine ER -