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Antibiotic resistance among Salmonella enterica serovars Typhi and Paratyphi A in Pakistan (2001-2006).
J Infect Dev Ctries. 2008 Aug 30; 2(4):289-94.JI

Abstract

OBJECTIVES

To compare antimicrobial resistance in S. Typhi and S. Paratyphi A isolates from Pakistan.

METHODS

Blood samples were collected through > 175 laboratory collection points in major cities and towns across the country. The study included 3,671 S. Typhi and 1,475 S. Paratyphi A isolates (2001-2006). Multidrug resistance (MDR) was defined as resistance to first-line agents co-trimoxazole, chloramphenicol and ampicillin.

RESULTS

In total, 79.3% S. Typhi and 59.9% S. Paratyphi A were isolated from patients under 15 years of age. During the study period, the MDR rate increased in S. Typhi (34.2 to 48.5% p<0.001). Quinolone resistance (MIC> 1 microg/ml) increased in both S. Typhi (1.6 to 64.1% p<0.001) and S. Paratyphi A (0 to 47% p<0.001). The increase in the proportion of strains showing high level quinolone resistance (MIC > 4 microg/ml) was greater in S. Paratyphi A when compared to S. Typhi. Resistance to first-line drugs was higher in those <15 years of age whereas quinolone resistance was higher in older patients.

CONCLUSION

Differences between S. Typhi and S. Paratyphi A, in terms of evolution of resistance to first-line agents and to quinolones, are evident in this population. The rapid increase in quinolone resistance in S. Paratyphi A when compared to S. Typhi is concerning and requires further study.

Authors+Show Affiliations

Department of Pathology & Microbiology, Aga Khan University Hospitals, Karachi 74800, Pakistan. rumina.hasan@aku.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19741291

Citation

Hasan, Rumina, et al. "Antibiotic Resistance Among Salmonella Enterica Serovars Typhi and Paratyphi a in Pakistan (2001-2006)." Journal of Infection in Developing Countries, vol. 2, no. 4, 2008, pp. 289-94.
Hasan R, Zafar A, Abbas Z, et al. Antibiotic resistance among Salmonella enterica serovars Typhi and Paratyphi A in Pakistan (2001-2006). J Infect Dev Ctries. 2008;2(4):289-94.
Hasan, R., Zafar, A., Abbas, Z., Mahraj, V., Malik, F., & Zaidi, A. (2008). Antibiotic resistance among Salmonella enterica serovars Typhi and Paratyphi A in Pakistan (2001-2006). Journal of Infection in Developing Countries, 2(4), 289-94.
Hasan R, et al. Antibiotic Resistance Among Salmonella Enterica Serovars Typhi and Paratyphi a in Pakistan (2001-2006). J Infect Dev Ctries. 2008 Aug 30;2(4):289-94. PubMed PMID: 19741291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotic resistance among Salmonella enterica serovars Typhi and Paratyphi A in Pakistan (2001-2006). AU - Hasan,Rumina, AU - Zafar,Afia, AU - Abbas,Zohair, AU - Mahraj,Vikram, AU - Malik,Faisal, AU - Zaidi,Anita, Y1 - 2008/08/30/ PY - 2008/06/19/received PY - 2009/9/11/entrez PY - 2008/1/1/pubmed PY - 2009/12/16/medline SP - 289 EP - 94 JF - Journal of infection in developing countries JO - J Infect Dev Ctries VL - 2 IS - 4 N2 - OBJECTIVES: To compare antimicrobial resistance in S. Typhi and S. Paratyphi A isolates from Pakistan. METHODS: Blood samples were collected through > 175 laboratory collection points in major cities and towns across the country. The study included 3,671 S. Typhi and 1,475 S. Paratyphi A isolates (2001-2006). Multidrug resistance (MDR) was defined as resistance to first-line agents co-trimoxazole, chloramphenicol and ampicillin. RESULTS: In total, 79.3% S. Typhi and 59.9% S. Paratyphi A were isolated from patients under 15 years of age. During the study period, the MDR rate increased in S. Typhi (34.2 to 48.5% p<0.001). Quinolone resistance (MIC> 1 microg/ml) increased in both S. Typhi (1.6 to 64.1% p<0.001) and S. Paratyphi A (0 to 47% p<0.001). The increase in the proportion of strains showing high level quinolone resistance (MIC > 4 microg/ml) was greater in S. Paratyphi A when compared to S. Typhi. Resistance to first-line drugs was higher in those <15 years of age whereas quinolone resistance was higher in older patients. CONCLUSION: Differences between S. Typhi and S. Paratyphi A, in terms of evolution of resistance to first-line agents and to quinolones, are evident in this population. The rapid increase in quinolone resistance in S. Paratyphi A when compared to S. Typhi is concerning and requires further study. SN - 1972-2680 UR - https://www.unboundmedicine.com/medline/citation/19741291/Antibiotic_resistance_among_Salmonella_enterica_serovars_Typhi_and_Paratyphi_A_in_Pakistan__2001_2006__ L2 - http://www.jidc.org/index.php/journal/article/view/19741291 DB - PRIME DP - Unbound Medicine ER -