Tags

Type your tag names separated by a space and hit enter

Depression impairs executive functioning in Parkinson disease patients with low educational level.
Cogn Behav Neurol. 2009 Sep; 22(3):167-72.CB

Abstract

OBJECTIVE

To assess overall cognitive performance and executive functioning of nondemented Parkinson disease (PD) patients, and the influence of variables such as depression and education on cognition.

BACKGROUND

Cognitive dysfunction in PD is common even in early stages. Different variables have been identified as potential risk factors for cognitive decline in PD. Some of these variables, such as depression and educational level, are complexly interrelated.

METHODS

Eighty-two (male:female 52:30) subjects underwent clinical assessment which included the Unified Parkinson's Disease Rating Scale, Schwab-England Scale, Hoehn-Yahr Scale, Beck Depression Inventory, the Frontal Assessment Battery (FAB), and the Mini-Mental State Examination (MMSE).

RESULTS

Patients with higher education, younger age, and who had a younger age at disease onset performed better on both the FAB and MMSE. Severity of disease correlated with worse cognitive performance. Performance on the FAB, but not the MMSE, worsened with increased severity of depressive symptoms. When patients were divided into groups with lower (< or =4 y of schooling) and higher (> or =5 y of schooling) education, the FAB and Beck Depression Inventory correlated negatively only in the group with lower educational level.

CONCLUSIONS

Patients with PD present with cognitive impairment even when nondemented. Depression may exacerbate executive dysfunction, especially in subjects with lower educational level.

Authors+Show Affiliations

Department of Internal Medicine, Neurology Unit, University Hospital, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil 30130-100.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19741326

Citation

Kummer, Arthur, et al. "Depression Impairs Executive Functioning in Parkinson Disease Patients With Low Educational Level." Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, vol. 22, no. 3, 2009, pp. 167-72.
Kummer A, Harsányi E, Dias FM, et al. Depression impairs executive functioning in Parkinson disease patients with low educational level. Cogn Behav Neurol. 2009;22(3):167-72.
Kummer, A., Harsányi, E., Dias, F. M., Cardoso, F., Caramelli, P., & Teixeira, A. L. (2009). Depression impairs executive functioning in Parkinson disease patients with low educational level. Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, 22(3), 167-72. https://doi.org/10.1097/WNN.0b013e3181b278f9
Kummer A, et al. Depression Impairs Executive Functioning in Parkinson Disease Patients With Low Educational Level. Cogn Behav Neurol. 2009;22(3):167-72. PubMed PMID: 19741326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression impairs executive functioning in Parkinson disease patients with low educational level. AU - Kummer,Arthur, AU - Harsányi,Estefânia, AU - Dias,Fernando M V, AU - Cardoso,Francisco, AU - Caramelli,Paulo, AU - Teixeira,Antônio Lúcio, PY - 2009/9/11/entrez PY - 2009/9/11/pubmed PY - 2009/10/6/medline SP - 167 EP - 72 JF - Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology JO - Cogn Behav Neurol VL - 22 IS - 3 N2 - OBJECTIVE: To assess overall cognitive performance and executive functioning of nondemented Parkinson disease (PD) patients, and the influence of variables such as depression and education on cognition. BACKGROUND: Cognitive dysfunction in PD is common even in early stages. Different variables have been identified as potential risk factors for cognitive decline in PD. Some of these variables, such as depression and educational level, are complexly interrelated. METHODS: Eighty-two (male:female 52:30) subjects underwent clinical assessment which included the Unified Parkinson's Disease Rating Scale, Schwab-England Scale, Hoehn-Yahr Scale, Beck Depression Inventory, the Frontal Assessment Battery (FAB), and the Mini-Mental State Examination (MMSE). RESULTS: Patients with higher education, younger age, and who had a younger age at disease onset performed better on both the FAB and MMSE. Severity of disease correlated with worse cognitive performance. Performance on the FAB, but not the MMSE, worsened with increased severity of depressive symptoms. When patients were divided into groups with lower (< or =4 y of schooling) and higher (> or =5 y of schooling) education, the FAB and Beck Depression Inventory correlated negatively only in the group with lower educational level. CONCLUSIONS: Patients with PD present with cognitive impairment even when nondemented. Depression may exacerbate executive dysfunction, especially in subjects with lower educational level. SN - 1543-3641 UR - https://www.unboundmedicine.com/medline/citation/19741326/Depression_impairs_executive_functioning_in_Parkinson_disease_patients_with_low_educational_level_ L2 - https://doi.org/10.1097/WNN.0b013e3181b278f9 DB - PRIME DP - Unbound Medicine ER -