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[Morphological findings in cryptorchism in the adult male].
Boll Soc Ital Biol Sper 1990; 66(3):215-22BS

Abstract

Cryptorchidism, the most common endocrine disturbance in the newborn, is still present in 0.3% of all postpubertal men as monolateral or bilateral condition. The undescended testis, in postpubertal age, is permanently damaged, so about 80% of cryptorchids are subfertile or definitively sterile. In the present study we relate our observations on structure and ultrastructure of testicular biopsies obtained from 29 cryptorchid men aged from 16 to 64. The individual pattern of morphological alterations is closely related to age and position of undescended testis. The following aspects are recognizable in cryptorchid testis: 1) seminiferous tubules reduced in size and irregular in shape; 2) tubular lumen occluded; 3) reduced germ cell population; 4) altered stages of spermatogenesis; 5) increased thickness of spermatogonia layer; 6) vacuolization of germ cells; 7) polynucleated germ cells; 8) acrosomal deformities; 9) delivery of immature germ cells; 10) Sertolisation of the seminiferous tubule; 11) immature Sertoli cells; 12) multilayered and thickened basement lamina; 13) peritubular fibrosis; 14) vascular fibrosis; 15) vacuolisation of Leydig cells; 16) interstitial mastocytosis. The findings present a mosaic of the morphological events, that are characteristic not only of the undescended testis but also of numerous testicular pathologies as well as of other conditions as prolonged hyperthermia, experimental ischaemia and senescence.

Authors+Show Affiliations

Istituto di Anatomia umana normale, Università di Sassari.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

1974139

Citation

Montella, A, and A Pirino. "[Morphological Findings in Cryptorchism in the Adult Male]." Bollettino Della Societa Italiana Di Biologia Sperimentale, vol. 66, no. 3, 1990, pp. 215-22.
Montella A, Pirino A. [Morphological findings in cryptorchism in the adult male]. Boll Soc Ital Biol Sper. 1990;66(3):215-22.
Montella, A., & Pirino, A. (1990). [Morphological findings in cryptorchism in the adult male]. Bollettino Della Societa Italiana Di Biologia Sperimentale, 66(3), pp. 215-22.
Montella A, Pirino A. [Morphological Findings in Cryptorchism in the Adult Male]. Boll Soc Ital Biol Sper. 1990;66(3):215-22. PubMed PMID: 1974139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Morphological findings in cryptorchism in the adult male]. AU - Montella,A, AU - Pirino,A, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 215 EP - 22 JF - Bollettino della Societa italiana di biologia sperimentale JO - Boll. Soc. Ital. Biol. Sper. VL - 66 IS - 3 N2 - Cryptorchidism, the most common endocrine disturbance in the newborn, is still present in 0.3% of all postpubertal men as monolateral or bilateral condition. The undescended testis, in postpubertal age, is permanently damaged, so about 80% of cryptorchids are subfertile or definitively sterile. In the present study we relate our observations on structure and ultrastructure of testicular biopsies obtained from 29 cryptorchid men aged from 16 to 64. The individual pattern of morphological alterations is closely related to age and position of undescended testis. The following aspects are recognizable in cryptorchid testis: 1) seminiferous tubules reduced in size and irregular in shape; 2) tubular lumen occluded; 3) reduced germ cell population; 4) altered stages of spermatogenesis; 5) increased thickness of spermatogonia layer; 6) vacuolization of germ cells; 7) polynucleated germ cells; 8) acrosomal deformities; 9) delivery of immature germ cells; 10) Sertolisation of the seminiferous tubule; 11) immature Sertoli cells; 12) multilayered and thickened basement lamina; 13) peritubular fibrosis; 14) vascular fibrosis; 15) vacuolisation of Leydig cells; 16) interstitial mastocytosis. The findings present a mosaic of the morphological events, that are characteristic not only of the undescended testis but also of numerous testicular pathologies as well as of other conditions as prolonged hyperthermia, experimental ischaemia and senescence. SN - 0037-8771 UR - https://www.unboundmedicine.com/medline/citation/1974139/[Morphological_findings_in_cryptorchism_in_the_adult_male]_ DB - PRIME DP - Unbound Medicine ER -