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Opioid receptors and prejunctional modulation of capsaicin-sensitive sensory nerves in guinea-pig left atrium.
Gen Pharmacol. 1990; 21(4):417-21.GP

Abstract

1. In the isolated electrically driven left atria from reserpine-pretreated guinea-pigs and in presence of 1 microM atropine, electrical field stimulation (EFS) at 10 Hz produces a delayed positive inotropic response (DPIR) involving activation of capsaicin-sensitive afferents. 2. Opioids inhibited the DPIR with the following order of potency: dermorphin greater than [D-Ala2,N-MePhe4, Gly5-ol]-enkephalin (DAGO) greater than or equal to [D-Ala2,D-Leu5]-enkephalin (DADLE) greater than morphine greater than dynorphin A (1-13) greater than [D-Pen2,D-Pen5]-enkephalin (DPDPE). U-50488 was ineffective up to 10 microM. 3. Opioids also inhibited resting inotropism (3 Hz) with the following rank order of potency: DADLE greater than DAGO greater than U-50488 = dynorphin A (1-13) = morphine = DPDPE. 4. Both inhibition of the DPIR and inhibition of resting inotropism were prevented by 10 microM naloxone. 5. Neither dermorphin (0.1 microM) nor DAGO (0.3 microM) or DADLE (1 microM) inhibit responses produced by capsaicin (30 nM) or calcitonin gene-related peptide (3 nM). 6. These findings indicate that capsaicin-sensitive nerves in the guinea-pig atrium are endowed with mu opioid receptors which inhibit transmitter release when sensory nerve terminals are activated by EFS but not by capsaicin.

Authors+Show Affiliations

Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1974221

Citation

Giuliani, S, et al. "Opioid Receptors and Prejunctional Modulation of Capsaicin-sensitive Sensory Nerves in Guinea-pig Left Atrium." General Pharmacology, vol. 21, no. 4, 1990, pp. 417-21.
Giuliani S, Maggi CA, Meli A. Opioid receptors and prejunctional modulation of capsaicin-sensitive sensory nerves in guinea-pig left atrium. Gen Pharmacol. 1990;21(4):417-21.
Giuliani, S., Maggi, C. A., & Meli, A. (1990). Opioid receptors and prejunctional modulation of capsaicin-sensitive sensory nerves in guinea-pig left atrium. General Pharmacology, 21(4), 417-21.
Giuliani S, Maggi CA, Meli A. Opioid Receptors and Prejunctional Modulation of Capsaicin-sensitive Sensory Nerves in Guinea-pig Left Atrium. Gen Pharmacol. 1990;21(4):417-21. PubMed PMID: 1974221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opioid receptors and prejunctional modulation of capsaicin-sensitive sensory nerves in guinea-pig left atrium. AU - Giuliani,S, AU - Maggi,C A, AU - Meli,A, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 417 EP - 21 JF - General pharmacology JO - Gen Pharmacol VL - 21 IS - 4 N2 - 1. In the isolated electrically driven left atria from reserpine-pretreated guinea-pigs and in presence of 1 microM atropine, electrical field stimulation (EFS) at 10 Hz produces a delayed positive inotropic response (DPIR) involving activation of capsaicin-sensitive afferents. 2. Opioids inhibited the DPIR with the following order of potency: dermorphin greater than [D-Ala2,N-MePhe4, Gly5-ol]-enkephalin (DAGO) greater than or equal to [D-Ala2,D-Leu5]-enkephalin (DADLE) greater than morphine greater than dynorphin A (1-13) greater than [D-Pen2,D-Pen5]-enkephalin (DPDPE). U-50488 was ineffective up to 10 microM. 3. Opioids also inhibited resting inotropism (3 Hz) with the following rank order of potency: DADLE greater than DAGO greater than U-50488 = dynorphin A (1-13) = morphine = DPDPE. 4. Both inhibition of the DPIR and inhibition of resting inotropism were prevented by 10 microM naloxone. 5. Neither dermorphin (0.1 microM) nor DAGO (0.3 microM) or DADLE (1 microM) inhibit responses produced by capsaicin (30 nM) or calcitonin gene-related peptide (3 nM). 6. These findings indicate that capsaicin-sensitive nerves in the guinea-pig atrium are endowed with mu opioid receptors which inhibit transmitter release when sensory nerve terminals are activated by EFS but not by capsaicin. SN - 0306-3623 UR - https://www.unboundmedicine.com/medline/citation/1974221/Opioid_receptors_and_prejunctional_modulation_of_capsaicin_sensitive_sensory_nerves_in_guinea_pig_left_atrium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0306-3623(90)90691-E DB - PRIME DP - Unbound Medicine ER -