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Underlying mechanism of portal hypertensive gastropathy in cirrhosis: a hemodynamic and morphological approach.
J Gastroenterol Hepatol. 2009 Sep; 24(9):1541-6.JG

Abstract

BACKGROUND AND AIM

Portal hypertensive gastropathy (PHG) is an important cause of bleeding in patients with cirrhosis associated with portal hypertension. Histologically, the condition is characterized by dilation of the mucosal and submucosal vessels of the stomach; however, its mechanisms remain unclear. The aim of the present cross-sectional study was to evaluate the role of portal and systemic hemodynamic features, humoral factors and hepatocellular function in the development and severity of PHG in patients with cirrhosis.

METHODS

Forty-six patients with cirrhosis of different etiologies underwent endoscopy. Portal hypertension was evaluated by hepatic venous pressure gradient (HVPG). The gastric mucosa was analyzed using two diagnostic methods: endoscopy according to the McCormack criteria and histological by histomorphometric analysis.

RESULTS

The prevalence of PHG according to the endoscopic and histomorphometric methods was 93.4% and 76.1%, respectively. There were no statistically significant differences in HVPG measurements between the patients with mild (16.0 +/- 5.9 mmHg) and severe PHG (16.9 +/- 6.5 mmHg; P = 0.80) or between patients who did not have (15.2 +/- 8.0 mmHg) and those who had PHG (16.3 +/- 5.7 mmHg). No correlation was found between the presence or severity of PHG and systemic vascular resistance index (P = 0.53 and 0.34, respectively), Child-Pugh classification (P = 0.73 and 0.78, respectively) or glucagon levels (P = 0.59 and 0.62, respectively).

CONCLUSIONS

The present data show no correlation between the presence or the severity of PHG and portal pressure, Child-Pugh classification or systemic hemodynamics, suggesting that other factors may be involved in the physiopathology of PHG, such as local gastric mucosal factors or other underlying factors.

Authors+Show Affiliations

Department of Medicine, Division of Gastroenterology and Hepatology, Federal University of São Paulo, São Paulo, Brazil. liliancurvelo@uol.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19743998

Citation

Curvêlo, Lílian Amorim, et al. "Underlying Mechanism of Portal Hypertensive Gastropathy in Cirrhosis: a Hemodynamic and Morphological Approach." Journal of Gastroenterology and Hepatology, vol. 24, no. 9, 2009, pp. 1541-6.
Curvêlo LA, Brabosa W, Rhor R, et al. Underlying mechanism of portal hypertensive gastropathy in cirrhosis: a hemodynamic and morphological approach. J Gastroenterol Hepatol. 2009;24(9):1541-6.
Curvêlo, L. A., Brabosa, W., Rhor, R., Lanzoni, V., Parise, E. R., Ferrari, A. P., & Kondo, M. (2009). Underlying mechanism of portal hypertensive gastropathy in cirrhosis: a hemodynamic and morphological approach. Journal of Gastroenterology and Hepatology, 24(9), 1541-6. https://doi.org/10.1111/j.1440-1746.2009.05871.x
Curvêlo LA, et al. Underlying Mechanism of Portal Hypertensive Gastropathy in Cirrhosis: a Hemodynamic and Morphological Approach. J Gastroenterol Hepatol. 2009;24(9):1541-6. PubMed PMID: 19743998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Underlying mechanism of portal hypertensive gastropathy in cirrhosis: a hemodynamic and morphological approach. AU - Curvêlo,Lílian Amorim, AU - Brabosa,Walnei, AU - Rhor,Rachel, AU - Lanzoni,Valéria, AU - Parise,Edison Roberto, AU - Ferrari,Angelo Paulo, AU - Kondo,Mario, PY - 2009/9/12/entrez PY - 2009/9/12/pubmed PY - 2009/12/16/medline SP - 1541 EP - 6 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 24 IS - 9 N2 - BACKGROUND AND AIM: Portal hypertensive gastropathy (PHG) is an important cause of bleeding in patients with cirrhosis associated with portal hypertension. Histologically, the condition is characterized by dilation of the mucosal and submucosal vessels of the stomach; however, its mechanisms remain unclear. The aim of the present cross-sectional study was to evaluate the role of portal and systemic hemodynamic features, humoral factors and hepatocellular function in the development and severity of PHG in patients with cirrhosis. METHODS: Forty-six patients with cirrhosis of different etiologies underwent endoscopy. Portal hypertension was evaluated by hepatic venous pressure gradient (HVPG). The gastric mucosa was analyzed using two diagnostic methods: endoscopy according to the McCormack criteria and histological by histomorphometric analysis. RESULTS: The prevalence of PHG according to the endoscopic and histomorphometric methods was 93.4% and 76.1%, respectively. There were no statistically significant differences in HVPG measurements between the patients with mild (16.0 +/- 5.9 mmHg) and severe PHG (16.9 +/- 6.5 mmHg; P = 0.80) or between patients who did not have (15.2 +/- 8.0 mmHg) and those who had PHG (16.3 +/- 5.7 mmHg). No correlation was found between the presence or severity of PHG and systemic vascular resistance index (P = 0.53 and 0.34, respectively), Child-Pugh classification (P = 0.73 and 0.78, respectively) or glucagon levels (P = 0.59 and 0.62, respectively). CONCLUSIONS: The present data show no correlation between the presence or the severity of PHG and portal pressure, Child-Pugh classification or systemic hemodynamics, suggesting that other factors may be involved in the physiopathology of PHG, such as local gastric mucosal factors or other underlying factors. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/19743998/Underlying_mechanism_of_portal_hypertensive_gastropathy_in_cirrhosis:_a_hemodynamic_and_morphological_approach_ L2 - https://doi.org/10.1111/j.1440-1746.2009.05871.x DB - PRIME DP - Unbound Medicine ER -