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Effect of laparoscopic splenectomy on portal hypertensive gastropathy in cirrhotic patients with portal hypertension.
J Gastroenterol Hepatol. 2009 Sep; 24(9):1554-8.JG

Abstract

AIM

This study investigated the relationship between portal hypertensive gastropathy (PHG) and splenomegaly, and the effect of laparoscopic splenectomy on PHG in cirrhotic patients with portal hypertension.

METHODS

Seventy patients with liver cirrhosis and portal hypertension were prospectively studied. Indication for laparoscopic splenectomy was bleeding tendency in 10 patients, induction of interferon in 45, treatment of hepatocellular carcinoma in seven, and treatment for endoscopic injection sclerotherapy-resistant esophagogastric varices in eight. The severity of PHG was classified into none, mild, or severe according to the classification by McCormack et al. The severity of liver disease was classified using the Child-Pugh score. All patients underwent upper gastrointestinal endoscopy before and 1 month after the operation.

RESULTS

The prevalence of PHG was significantly correlated with the severity of liver disease using the Child-Pugh score. The severity of PHG was significantly correlated with the resected spleen volume. One month after the operation, PHG was improved in 16 of 17 patients with severe PHG and in 12 of 32 with mild PHG. The Child-Pugh score showed a significant improvement (6.8 +/- 1.4 to 6.2 +/- 1.2) at 3 months after laparoscopic splenectomy (P < 0.0001).

CONCLUSIONS

PHG may be associated with splenomegaly, and laparoscopic splenectomy may have a beneficial effect on PHG, at least for a short time.

Authors+Show Affiliations

Department of Surgery, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. gottin@surg2.med.kyushu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19743999

Citation

Anegawa, Go, et al. "Effect of Laparoscopic Splenectomy On Portal Hypertensive Gastropathy in Cirrhotic Patients With Portal Hypertension." Journal of Gastroenterology and Hepatology, vol. 24, no. 9, 2009, pp. 1554-8.
Anegawa G, Kawanaka H, Uehara H, et al. Effect of laparoscopic splenectomy on portal hypertensive gastropathy in cirrhotic patients with portal hypertension. J Gastroenterol Hepatol. 2009;24(9):1554-8.
Anegawa, G., Kawanaka, H., Uehara, H., Akahoshi, T., Konishi, K., Yoshida, D., Kinjo, N., Hashimoto, N., Tomikawa, M., Hashizume, M., & Maehara, Y. (2009). Effect of laparoscopic splenectomy on portal hypertensive gastropathy in cirrhotic patients with portal hypertension. Journal of Gastroenterology and Hepatology, 24(9), 1554-8. https://doi.org/10.1111/j.1440-1746.2009.05906.x
Anegawa G, et al. Effect of Laparoscopic Splenectomy On Portal Hypertensive Gastropathy in Cirrhotic Patients With Portal Hypertension. J Gastroenterol Hepatol. 2009;24(9):1554-8. PubMed PMID: 19743999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of laparoscopic splenectomy on portal hypertensive gastropathy in cirrhotic patients with portal hypertension. AU - Anegawa,Go, AU - Kawanaka,Hirofumi, AU - Uehara,Hideo, AU - Akahoshi,Tomohiko, AU - Konishi,Kozo, AU - Yoshida,Daisuke, AU - Kinjo,Nao, AU - Hashimoto,Naotaka, AU - Tomikawa,Morimasa, AU - Hashizume,Makoto, AU - Maehara,Yoshihiko, PY - 2009/9/12/entrez PY - 2009/9/12/pubmed PY - 2009/12/16/medline SP - 1554 EP - 8 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 24 IS - 9 N2 - AIM: This study investigated the relationship between portal hypertensive gastropathy (PHG) and splenomegaly, and the effect of laparoscopic splenectomy on PHG in cirrhotic patients with portal hypertension. METHODS: Seventy patients with liver cirrhosis and portal hypertension were prospectively studied. Indication for laparoscopic splenectomy was bleeding tendency in 10 patients, induction of interferon in 45, treatment of hepatocellular carcinoma in seven, and treatment for endoscopic injection sclerotherapy-resistant esophagogastric varices in eight. The severity of PHG was classified into none, mild, or severe according to the classification by McCormack et al. The severity of liver disease was classified using the Child-Pugh score. All patients underwent upper gastrointestinal endoscopy before and 1 month after the operation. RESULTS: The prevalence of PHG was significantly correlated with the severity of liver disease using the Child-Pugh score. The severity of PHG was significantly correlated with the resected spleen volume. One month after the operation, PHG was improved in 16 of 17 patients with severe PHG and in 12 of 32 with mild PHG. The Child-Pugh score showed a significant improvement (6.8 +/- 1.4 to 6.2 +/- 1.2) at 3 months after laparoscopic splenectomy (P < 0.0001). CONCLUSIONS: PHG may be associated with splenomegaly, and laparoscopic splenectomy may have a beneficial effect on PHG, at least for a short time. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/19743999/Effect_of_laparoscopic_splenectomy_on_portal_hypertensive_gastropathy_in_cirrhotic_patients_with_portal_hypertension_ L2 - https://doi.org/10.1111/j.1440-1746.2009.05906.x DB - PRIME DP - Unbound Medicine ER -