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Five-year experience in the treatment of alopecia areata with DPC.
J Eur Acad Dermatol Venereol. 2010 Mar; 24(3):264-9.JE

Abstract

BACKGROUND

The effectiveness of Diphencyprone (DPC) in alopecia areata (AA) was demonstrated in several studies with highly variable response rates ranging from 5% to 85%.

OBJECTIVE

The response rate and variable factors affecting the prognosis were studied focusing on long-term follow-up with or without maintenance therapy.

METHODS

A total of 135 cases of AA were treated with DPC. Patients were divided into five groups according to the area of scalp affected: Grade 1 AA: 25-49% scalp affection; Grade 2 AA: 50-74% scalp affection; Grade 3 AA: 75-99% scalp affection; alopecia totalis and alopecia universalis. An initial response was defined as appearance of new terminal hair within treated sites. Excellent response was defined as terminal hair covering >75% of the scalp. Relapse meant >25% hair loss. Maintenance therapy meant ongoing therapy once every 1-4 weeks after excellent response. Follow-up was performed to detect any relapse of AA.

RESULTS

Ninety-seven patients continued therapy for >or=3 months. After an initial 3 month lag, cumulative excellent response was seen in 15 patients (15.4%), 47 patients (48.5%), 51 patients (52.6%) and 55 patients (55.7%) after 6, 12, 18 and 24 months respectively in a mean median time of 12 months. The only patient variable affecting the prognosis was baseline extent of AA. Excellent response was seen in 100%, 77%, 54%, 50% and 41% in Grade 1, Grade 2, Grade 3, AA totalis and AA universalis patients respectively. Side-effects were few and tolerable. Hair fall >25% occurred in 17.9% of patients on maintenance and 57.1% of patients without maintenance therapy (P-value=0.025).

CONCLUSION

Diphencyprone is an effective and safe treatment of extensive AA. A long period of therapy is needed and will increase the percentage of responders especially in alopecia totalis and universalis. Maintenance therapy is recommended to reduce the risk of relapse.

Authors+Show Affiliations

The Department of Dermatology, Kasr El-Aini University Hospital, Cairo University, Cairo, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19744175

Citation

El-Zawahry, B M., et al. "Five-year Experience in the Treatment of Alopecia Areata With DPC." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 24, no. 3, 2010, pp. 264-9.
El-Zawahry BM, Bassiouny DA, Khella A, et al. Five-year experience in the treatment of alopecia areata with DPC. J Eur Acad Dermatol Venereol. 2010;24(3):264-9.
El-Zawahry, B. M., Bassiouny, D. A., Khella, A., & Zaki, N. S. (2010). Five-year experience in the treatment of alopecia areata with DPC. Journal of the European Academy of Dermatology and Venereology : JEADV, 24(3), 264-9. https://doi.org/10.1111/j.1468-3083.2009.03401.x
El-Zawahry BM, et al. Five-year Experience in the Treatment of Alopecia Areata With DPC. J Eur Acad Dermatol Venereol. 2010;24(3):264-9. PubMed PMID: 19744175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five-year experience in the treatment of alopecia areata with DPC. AU - El-Zawahry,B M, AU - Bassiouny,D A, AU - Khella,A, AU - Zaki,N S, Y1 - 2009/09/08/ PY - 2009/9/12/entrez PY - 2009/9/12/pubmed PY - 2010/10/6/medline SP - 264 EP - 9 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 24 IS - 3 N2 - BACKGROUND: The effectiveness of Diphencyprone (DPC) in alopecia areata (AA) was demonstrated in several studies with highly variable response rates ranging from 5% to 85%. OBJECTIVE: The response rate and variable factors affecting the prognosis were studied focusing on long-term follow-up with or without maintenance therapy. METHODS: A total of 135 cases of AA were treated with DPC. Patients were divided into five groups according to the area of scalp affected: Grade 1 AA: 25-49% scalp affection; Grade 2 AA: 50-74% scalp affection; Grade 3 AA: 75-99% scalp affection; alopecia totalis and alopecia universalis. An initial response was defined as appearance of new terminal hair within treated sites. Excellent response was defined as terminal hair covering >75% of the scalp. Relapse meant >25% hair loss. Maintenance therapy meant ongoing therapy once every 1-4 weeks after excellent response. Follow-up was performed to detect any relapse of AA. RESULTS: Ninety-seven patients continued therapy for >or=3 months. After an initial 3 month lag, cumulative excellent response was seen in 15 patients (15.4%), 47 patients (48.5%), 51 patients (52.6%) and 55 patients (55.7%) after 6, 12, 18 and 24 months respectively in a mean median time of 12 months. The only patient variable affecting the prognosis was baseline extent of AA. Excellent response was seen in 100%, 77%, 54%, 50% and 41% in Grade 1, Grade 2, Grade 3, AA totalis and AA universalis patients respectively. Side-effects were few and tolerable. Hair fall >25% occurred in 17.9% of patients on maintenance and 57.1% of patients without maintenance therapy (P-value=0.025). CONCLUSION: Diphencyprone is an effective and safe treatment of extensive AA. A long period of therapy is needed and will increase the percentage of responders especially in alopecia totalis and universalis. Maintenance therapy is recommended to reduce the risk of relapse. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/19744175/Five_year_experience_in_the_treatment_of_alopecia_areata_with_DPC_ L2 - https://doi.org/10.1111/j.1468-3083.2009.03401.x DB - PRIME DP - Unbound Medicine ER -