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Kinetics of interferon-gamma producing cytomegalovirus (CMV)-specific CD4+ and CD8+ T lymphocytes and the risk of subsequent CMV viremia after allogeneic hematopoietic stem cell transplantation.
Transpl Infect Dis. 2009 Dec; 11(6):519-28.TI

Abstract

BACKGROUND

Deficiencies in cytomegalovirus (CMV)-specific T lymphocytes impair the immunologic response against CMV reactivation after allogeneic hematopoietic stem cell transplantation (HSCT).

METHODS

A time-dependent analysis was conducted to determine the association between the percentages and kinetics of interferon-gamma-producing CMV-specific CD4+ and CD8+ T lymphocytes and CMV viremia among 30 allogeneic HSCT recipients.

RESULTS

Higher percentages of CD4+ T lymphocytes activated with CMVpp65 (hazard ratio [HR]: 2.06; 95% confidence interval [95% CI]: 1.18-3.6; P=0.011) and CMV lysate (HR: 1.18; 95% CI: 0.99-1.42; P=0.072), and higher percentages of CD8+ T lymphocytes activated by CMV immediate early-1 (HR: 1.2; 95% CI: 1.01-1.43; P=0.038) and CMVpp65 (HR: 1.12; 95% CI: 1.0-1.27; P=0.060) were associated with time-to-CMV viremia. Furthermore, a higher degree in the decline of CMV lysate-activated CD4+ T lymphocytes (HR: 1.14; 95% CI: 0.96-1.36; P=0.125) and CMVpp65-activated CD8+ T lymphocytes (HR: 1.36; 95% CI: 1.03-1.78; P=0.031) was suggestive of or significantly associated with time-to-CMV viremia.

CONCLUSIONS

Higher levels of CMV-specific CD4+ and CD8+ T lymphocytes were associated with subsequent CMV viremia after HSCT. The association between CMV viremia and the degree of decline in CMV-specific T lymphocytes suggests that severe disruption in homeostatic CMV-specific immune environment contributes to the immunopathogenesis of CMV after allogeneic HSCT.

Authors+Show Affiliations

Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19744286

Citation

Eid, A J., et al. "Kinetics of Interferon-gamma Producing Cytomegalovirus (CMV)-specific CD4+ and CD8+ T Lymphocytes and the Risk of Subsequent CMV Viremia After Allogeneic Hematopoietic Stem Cell Transplantation." Transplant Infectious Disease : an Official Journal of the Transplantation Society, vol. 11, no. 6, 2009, pp. 519-28.
Eid AJ, Brown RA, Hogan WJ, et al. Kinetics of interferon-gamma producing cytomegalovirus (CMV)-specific CD4+ and CD8+ T lymphocytes and the risk of subsequent CMV viremia after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 2009;11(6):519-28.
Eid, A. J., Brown, R. A., Hogan, W. J., Lahr, B. D., Eckel-Passow, J. E., Litzow, M. R., & Razonable, R. R. (2009). Kinetics of interferon-gamma producing cytomegalovirus (CMV)-specific CD4+ and CD8+ T lymphocytes and the risk of subsequent CMV viremia after allogeneic hematopoietic stem cell transplantation. Transplant Infectious Disease : an Official Journal of the Transplantation Society, 11(6), 519-28. https://doi.org/10.1111/j.1399-3062.2009.00446.x
Eid AJ, et al. Kinetics of Interferon-gamma Producing Cytomegalovirus (CMV)-specific CD4+ and CD8+ T Lymphocytes and the Risk of Subsequent CMV Viremia After Allogeneic Hematopoietic Stem Cell Transplantation. Transpl Infect Dis. 2009;11(6):519-28. PubMed PMID: 19744286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinetics of interferon-gamma producing cytomegalovirus (CMV)-specific CD4+ and CD8+ T lymphocytes and the risk of subsequent CMV viremia after allogeneic hematopoietic stem cell transplantation. AU - Eid,A J, AU - Brown,R A, AU - Hogan,W J, AU - Lahr,B D, AU - Eckel-Passow,J E, AU - Litzow,M R, AU - Razonable,R R, Y1 - 2009/09/09/ PY - 2009/9/12/entrez PY - 2009/9/12/pubmed PY - 2010/2/27/medline SP - 519 EP - 28 JF - Transplant infectious disease : an official journal of the Transplantation Society JO - Transpl Infect Dis VL - 11 IS - 6 N2 - BACKGROUND: Deficiencies in cytomegalovirus (CMV)-specific T lymphocytes impair the immunologic response against CMV reactivation after allogeneic hematopoietic stem cell transplantation (HSCT). METHODS: A time-dependent analysis was conducted to determine the association between the percentages and kinetics of interferon-gamma-producing CMV-specific CD4+ and CD8+ T lymphocytes and CMV viremia among 30 allogeneic HSCT recipients. RESULTS: Higher percentages of CD4+ T lymphocytes activated with CMVpp65 (hazard ratio [HR]: 2.06; 95% confidence interval [95% CI]: 1.18-3.6; P=0.011) and CMV lysate (HR: 1.18; 95% CI: 0.99-1.42; P=0.072), and higher percentages of CD8+ T lymphocytes activated by CMV immediate early-1 (HR: 1.2; 95% CI: 1.01-1.43; P=0.038) and CMVpp65 (HR: 1.12; 95% CI: 1.0-1.27; P=0.060) were associated with time-to-CMV viremia. Furthermore, a higher degree in the decline of CMV lysate-activated CD4+ T lymphocytes (HR: 1.14; 95% CI: 0.96-1.36; P=0.125) and CMVpp65-activated CD8+ T lymphocytes (HR: 1.36; 95% CI: 1.03-1.78; P=0.031) was suggestive of or significantly associated with time-to-CMV viremia. CONCLUSIONS: Higher levels of CMV-specific CD4+ and CD8+ T lymphocytes were associated with subsequent CMV viremia after HSCT. The association between CMV viremia and the degree of decline in CMV-specific T lymphocytes suggests that severe disruption in homeostatic CMV-specific immune environment contributes to the immunopathogenesis of CMV after allogeneic HSCT. SN - 1399-3062 UR - https://www.unboundmedicine.com/medline/citation/19744286/Kinetics_of_interferon_gamma_producing_cytomegalovirus__CMV__specific_CD4+_and_CD8+_T_lymphocytes_and_the_risk_of_subsequent_CMV_viremia_after_allogeneic_hematopoietic_stem_cell_transplantation_ L2 - https://doi.org/10.1111/j.1399-3062.2009.00446.x DB - PRIME DP - Unbound Medicine ER -