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Comparison of retinal nerve fiber layer thickness values using Stratus Optical Coherence Tomography and Heidelberg Retina Tomograph-III.
J Glaucoma. 2009 Sep; 18(7):528-34.JG

Abstract

PURPOSE

To evaluate the usefulness of retinal nerve fiber layer (RNFL) thickness measurements using the Heidelberg Retina Tomograph-III (HRT-III) in normal, ocular hypertensive, and glaucomatous eyes and compare the thickness measurements using HRT-III and Stratus Optical Coherence Tomography-3 (OCT-3).

METHODS

Sixty-nine normal eyes, 60 eyes ocular hypertensive, and 111 glaucomatous were included. All participants underwent visual field, HRT-III, and OCT-3 examinations on the same day. Patients were classified into 3 groups according to intraocular pressure and visual field damage. The sensitivity/specificity of RNFL thickness measurements and RNFL thickness classifications using HRT-III and OCT-3 were calculated. The sensitivity/specificity of the height variation contour (HVC) from the HRT-III were calculated. The receiver operating characteristic curves (ROC) and areas under the ROC were plotted. Agreement was calculated using Bland-Altman method and the kappa coefficient.

RESULTS

The RNFL thickness sensitivity/specificity were 32.4%/87%, for the HRT-III and 72.97%/81.15% for the OCT-3 in relation to the glaucoma diagnosis (least specific criteria). The RNFL thickness sensitivities/specificities were lower in early glaucoma. The areas under the ROC for RNFL measurements were 0.72 using HRT-III, 0.86 with OCT-3 (P=0.001), and 0.54 for the HVC. The RNFL classification kappa coefficient was 0.36. Bland-Altman analysis confirmed that the RNFL measurements were not interchangeable.

CONCLUSIONS

The sensitivity of RNFL damage detection using HRT-III was lower compared with OCT-3, especially in early glaucoma. RNFL thickness agreement between HRT-III and OCT-3 was only fair. HVC was not useful for glaucoma detection.

Authors+Show Affiliations

Department of Ophthalmology, Clínica Universitaria, Universidad de Navarra, Pamplona, Spain. jmoreno@unav.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19745667

Citation

Moreno-Montañés, Javier, et al. "Comparison of Retinal Nerve Fiber Layer Thickness Values Using Stratus Optical Coherence Tomography and Heidelberg Retina Tomograph-III." Journal of Glaucoma, vol. 18, no. 7, 2009, pp. 528-34.
Moreno-Montañés J, Antón A, García N, et al. Comparison of retinal nerve fiber layer thickness values using Stratus Optical Coherence Tomography and Heidelberg Retina Tomograph-III. J Glaucoma. 2009;18(7):528-34.
Moreno-Montañés, J., Antón, A., García, N., Olmo, N., Morilla, A., & Fallon, M. (2009). Comparison of retinal nerve fiber layer thickness values using Stratus Optical Coherence Tomography and Heidelberg Retina Tomograph-III. Journal of Glaucoma, 18(7), 528-34. https://doi.org/10.1097/IJG.0b013e318193c29f
Moreno-Montañés J, et al. Comparison of Retinal Nerve Fiber Layer Thickness Values Using Stratus Optical Coherence Tomography and Heidelberg Retina Tomograph-III. J Glaucoma. 2009;18(7):528-34. PubMed PMID: 19745667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of retinal nerve fiber layer thickness values using Stratus Optical Coherence Tomography and Heidelberg Retina Tomograph-III. AU - Moreno-Montañés,Javier, AU - Antón,Alfonso, AU - García,Noelia, AU - Olmo,Natalia, AU - Morilla,Antonio, AU - Fallon,Mónica, PY - 2009/9/12/entrez PY - 2009/9/12/pubmed PY - 2009/11/13/medline SP - 528 EP - 34 JF - Journal of glaucoma JO - J Glaucoma VL - 18 IS - 7 N2 - PURPOSE: To evaluate the usefulness of retinal nerve fiber layer (RNFL) thickness measurements using the Heidelberg Retina Tomograph-III (HRT-III) in normal, ocular hypertensive, and glaucomatous eyes and compare the thickness measurements using HRT-III and Stratus Optical Coherence Tomography-3 (OCT-3). METHODS: Sixty-nine normal eyes, 60 eyes ocular hypertensive, and 111 glaucomatous were included. All participants underwent visual field, HRT-III, and OCT-3 examinations on the same day. Patients were classified into 3 groups according to intraocular pressure and visual field damage. The sensitivity/specificity of RNFL thickness measurements and RNFL thickness classifications using HRT-III and OCT-3 were calculated. The sensitivity/specificity of the height variation contour (HVC) from the HRT-III were calculated. The receiver operating characteristic curves (ROC) and areas under the ROC were plotted. Agreement was calculated using Bland-Altman method and the kappa coefficient. RESULTS: The RNFL thickness sensitivity/specificity were 32.4%/87%, for the HRT-III and 72.97%/81.15% for the OCT-3 in relation to the glaucoma diagnosis (least specific criteria). The RNFL thickness sensitivities/specificities were lower in early glaucoma. The areas under the ROC for RNFL measurements were 0.72 using HRT-III, 0.86 with OCT-3 (P=0.001), and 0.54 for the HVC. The RNFL classification kappa coefficient was 0.36. Bland-Altman analysis confirmed that the RNFL measurements were not interchangeable. CONCLUSIONS: The sensitivity of RNFL damage detection using HRT-III was lower compared with OCT-3, especially in early glaucoma. RNFL thickness agreement between HRT-III and OCT-3 was only fair. HVC was not useful for glaucoma detection. SN - 1536-481X UR - https://www.unboundmedicine.com/medline/citation/19745667/Comparison_of_retinal_nerve_fiber_layer_thickness_values_using_Stratus_Optical_Coherence_Tomography_and_Heidelberg_Retina_Tomograph_III_ L2 - https://doi.org/10.1097/IJG.0b013e318193c29f DB - PRIME DP - Unbound Medicine ER -