Tags

Type your tag names separated by a space and hit enter

Involvement of non-enzymatic antioxidant defenses in the protective effect of diphenyl diselenide on testicular damage induced by cadmium in mice.
J Trace Elem Med Biol. 2009; 23(4):324-33.JT

Abstract

The involvement of non-enzymatic antioxidant defenses in the protective effect of diphenyl diselenide (PhSe)(2) on testicular damage caused by cadmium in mice was investigated. Mice received a single dose of CdCl(2) (5mg/kg, intraperitoneally). Thirty minutes after the CdCl(2) injection, they received a single oral dose of (PhSe)(2) (400micromol/kg). Twenty-four hours after CdCl(2) administration, blood samples were collected and mice were killed and had their testes dissected. Parameters in plasma (aspartate (AST) and alanine (ALT) aminotransferases and lactato dehydrogenase (LDH) activities as well as creatinine levels) were determined. The activity of delta-aminolevulinate dehydratase (delta-ALA-D), the levels of thiobarbituric acid-reactive substances (TBARS), ascorbic acid and nonprotein thiols (NPSH) and histological analysis were determined in collected samples. Results demonstrated that (PhSe)(2) protected against toxicity induced by CdCl(2) on delta-ALA-D activity, ascorbic acid and NPSH levels. (PhSe)(2) protected against the increase in plasma AST, ALT and LDH activities caused by CdCl(2). Testes of mice exposed to CdCl(2) showed marked histopathological alterations that were ameliorated by administration of (PhSe)(2). (PhSe)(2) protected against toxicity induced by CdCl(2) in testes of mice. Ascorbic acid and NPSH, non-enzymatic antioxidant defenses, are involved in the protective effect of (PhSe)(2) against testicular damage caused by CdCl(2) in mice.

Authors+Show Affiliations

Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19747628

Citation

Brandão, Ricardo, et al. "Involvement of Non-enzymatic Antioxidant Defenses in the Protective Effect of Diphenyl Diselenide On Testicular Damage Induced By Cadmium in Mice." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 23, no. 4, 2009, pp. 324-33.
Brandão R, Santos FW, Oliveira R, et al. Involvement of non-enzymatic antioxidant defenses in the protective effect of diphenyl diselenide on testicular damage induced by cadmium in mice. J Trace Elem Med Biol. 2009;23(4):324-33.
Brandão, R., Santos, F. W., Oliveira, R., Roman, S. S., & Nogueira, C. W. (2009). Involvement of non-enzymatic antioxidant defenses in the protective effect of diphenyl diselenide on testicular damage induced by cadmium in mice. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 23(4), 324-33. https://doi.org/10.1016/j.jtemb.2009.06.006
Brandão R, et al. Involvement of Non-enzymatic Antioxidant Defenses in the Protective Effect of Diphenyl Diselenide On Testicular Damage Induced By Cadmium in Mice. J Trace Elem Med Biol. 2009;23(4):324-33. PubMed PMID: 19747628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of non-enzymatic antioxidant defenses in the protective effect of diphenyl diselenide on testicular damage induced by cadmium in mice. AU - Brandão,Ricardo, AU - Santos,Francielli Weber, AU - Oliveira,Renata, AU - Roman,Silvane Souza, AU - Nogueira,Cristina Wayne, Y1 - 2009/08/05/ PY - 2008/06/20/received PY - 2009/06/19/revised PY - 2009/06/21/accepted PY - 2009/9/15/entrez PY - 2009/9/15/pubmed PY - 2009/10/16/medline SP - 324 EP - 33 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 23 IS - 4 N2 - The involvement of non-enzymatic antioxidant defenses in the protective effect of diphenyl diselenide (PhSe)(2) on testicular damage caused by cadmium in mice was investigated. Mice received a single dose of CdCl(2) (5mg/kg, intraperitoneally). Thirty minutes after the CdCl(2) injection, they received a single oral dose of (PhSe)(2) (400micromol/kg). Twenty-four hours after CdCl(2) administration, blood samples were collected and mice were killed and had their testes dissected. Parameters in plasma (aspartate (AST) and alanine (ALT) aminotransferases and lactato dehydrogenase (LDH) activities as well as creatinine levels) were determined. The activity of delta-aminolevulinate dehydratase (delta-ALA-D), the levels of thiobarbituric acid-reactive substances (TBARS), ascorbic acid and nonprotein thiols (NPSH) and histological analysis were determined in collected samples. Results demonstrated that (PhSe)(2) protected against toxicity induced by CdCl(2) on delta-ALA-D activity, ascorbic acid and NPSH levels. (PhSe)(2) protected against the increase in plasma AST, ALT and LDH activities caused by CdCl(2). Testes of mice exposed to CdCl(2) showed marked histopathological alterations that were ameliorated by administration of (PhSe)(2). (PhSe)(2) protected against toxicity induced by CdCl(2) in testes of mice. Ascorbic acid and NPSH, non-enzymatic antioxidant defenses, are involved in the protective effect of (PhSe)(2) against testicular damage caused by CdCl(2) in mice. SN - 1878-3252 UR - https://www.unboundmedicine.com/medline/citation/19747628/Involvement_of_non_enzymatic_antioxidant_defenses_in_the_protective_effect_of_diphenyl_diselenide_on_testicular_damage_induced_by_cadmium_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(09)00088-1 DB - PRIME DP - Unbound Medicine ER -