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A travel medicine view of dengue and dengue hemorrhagic fever.
Travel Med Infect Dis. 2009 Sep; 7(5):278-83.TM

Abstract

Dengue fever is the most prevalent arboviral infection worldwide, with up to 40% of the world population living in endemic regions. Among travelers to tropical countries, dengue infection is increasingly reported, and it is now a leading cause of post-travel fever. Outbreaks of dengue-like illness were already described since the 18th century, but it is only in the last half century that a severe form of the disease - dengue hemorrhagic fever (DHF) has been described. Although the cause of DHF is not established, the prevailing theory attributes the disease to antibody-dependent enhancement of viral replication, in the presence of a secondary dengue infection. Comparative studies of primary vs. secondary infection are difficult to perform in endemic countries because of the rarity of primary infection except during early infancy. Travelers on the other hand are usually diagnosed with primary infection and are therefore a better study population. Data on dengue and DHF among travelers appears to suggest that severe dengue and DHF occur in similar rates among cases with primary and with secondary infections. Epidemiological and physiological data from travelers suggest that the prevailing theory on the causes of DHF needs to be reconsidered.

Authors+Show Affiliations

The Center for Geographic Medicine and Department of Medicine C, The Chaim Sheba Medical Center, Tel Hashomer 52621 Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. emeltzer@post.tau.ac.ilNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19747662

Citation

Meltzer, Eyal, and Eli Schwartz. "A Travel Medicine View of Dengue and Dengue Hemorrhagic Fever." Travel Medicine and Infectious Disease, vol. 7, no. 5, 2009, pp. 278-83.
Meltzer E, Schwartz E. A travel medicine view of dengue and dengue hemorrhagic fever. Travel Med Infect Dis. 2009;7(5):278-83.
Meltzer, E., & Schwartz, E. (2009). A travel medicine view of dengue and dengue hemorrhagic fever. Travel Medicine and Infectious Disease, 7(5), 278-83. https://doi.org/10.1016/j.tmaid.2009.05.002
Meltzer E, Schwartz E. A Travel Medicine View of Dengue and Dengue Hemorrhagic Fever. Travel Med Infect Dis. 2009;7(5):278-83. PubMed PMID: 19747662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A travel medicine view of dengue and dengue hemorrhagic fever. AU - Meltzer,Eyal, AU - Schwartz,Eli, Y1 - 2009/07/22/ PY - 2009/04/19/received PY - 2009/05/06/accepted PY - 2009/9/15/entrez PY - 2009/9/15/pubmed PY - 2010/1/1/medline SP - 278 EP - 83 JF - Travel medicine and infectious disease JO - Travel Med Infect Dis VL - 7 IS - 5 N2 - Dengue fever is the most prevalent arboviral infection worldwide, with up to 40% of the world population living in endemic regions. Among travelers to tropical countries, dengue infection is increasingly reported, and it is now a leading cause of post-travel fever. Outbreaks of dengue-like illness were already described since the 18th century, but it is only in the last half century that a severe form of the disease - dengue hemorrhagic fever (DHF) has been described. Although the cause of DHF is not established, the prevailing theory attributes the disease to antibody-dependent enhancement of viral replication, in the presence of a secondary dengue infection. Comparative studies of primary vs. secondary infection are difficult to perform in endemic countries because of the rarity of primary infection except during early infancy. Travelers on the other hand are usually diagnosed with primary infection and are therefore a better study population. Data on dengue and DHF among travelers appears to suggest that severe dengue and DHF occur in similar rates among cases with primary and with secondary infections. Epidemiological and physiological data from travelers suggest that the prevailing theory on the causes of DHF needs to be reconsidered. SN - 1873-0442 UR - https://www.unboundmedicine.com/medline/citation/19747662/A_travel_medicine_view_of_dengue_and_dengue_hemorrhagic_fever_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1477-8939(09)00084-2 DB - PRIME DP - Unbound Medicine ER -
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