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Plant sterols from rapeseed and tall oils: effects on lipids, fat-soluble vitamins and plant sterol concentrations.
Nutr Metab Cardiovasc Dis. 2010 May; 20(4):258-65.NM

Abstract

BACKGROUND AND AIMS

Data comparing the impact of different sources of plant sterols on CVD risk factors and antioxidant levels is scarce. We evaluated the effects of plant sterols from rapeseed and tall oils on serum lipids, lipoproteins, fat-soluble vitamins and plant sterol concentrations.

METHODS AND RESULTS

This was a double-blinded, randomized, crossover trial in which 59 hypercholesterolemic subjects consumed 25 g/day of margarine for 4 weeks separated by 1 week washout periods. The two experimental margarines provided 2g/day of plant sterols from rapeseed or tall oil. The control margarine had no added plant sterols. The control margarine reduced LDL cholesterol by 4.5% (95% CI 1.4, 7.6%). The tall and rapeseed sterol margarines additionally reduced LDL cholesterol by 9.0% (95% CI 5.5, 12.4%) and 8.2% (95% CI 5.2, 11.4%) and apolipoprotein B by 5.3% (95% CI 1.0, 9.6%) and 6.9% (95% CI 3.6, 10.2%), respectively. Lipid-adjusted beta-carotene concentrations were reduced by both sterol margarines (P<0.017). alpha-Tocopherol concentrations were reduced by the tall sterol compared to the rapeseed sterol margarine (P=0.001). Campesterol concentrations increased more markedly with the rapeseed sterol versus tall sterol margarine (P<0.001). The rapeseed sterol margarine increased while the tall sterol margarine decreased brassicasterol concentrations (P<0.001).

CONCLUSIONS

Plant sterols from tall and rapeseed oils reduce atherogenic lipids and lipoproteins similarly. The rapeseed sterol margarine may have more favorable effects on serum alpha-tocopherol concentrations.

Authors+Show Affiliations

Department of Preventive Cardiology, Ullevaal University Hospital, Oslo, Norway. eli.heggen@uus.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19748247

Citation

Heggen, E, et al. "Plant Sterols From Rapeseed and Tall Oils: Effects On Lipids, Fat-soluble Vitamins and Plant Sterol Concentrations." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 20, no. 4, 2010, pp. 258-65.
Heggen E, Granlund L, Pedersen JI, et al. Plant sterols from rapeseed and tall oils: effects on lipids, fat-soluble vitamins and plant sterol concentrations. Nutr Metab Cardiovasc Dis. 2010;20(4):258-65.
Heggen, E., Granlund, L., Pedersen, J. I., Holme, I., Ceglarek, U., Thiery, J., Kirkhus, B., & Tonstad, S. (2010). Plant sterols from rapeseed and tall oils: effects on lipids, fat-soluble vitamins and plant sterol concentrations. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 20(4), 258-65. https://doi.org/10.1016/j.numecd.2009.04.001
Heggen E, et al. Plant Sterols From Rapeseed and Tall Oils: Effects On Lipids, Fat-soluble Vitamins and Plant Sterol Concentrations. Nutr Metab Cardiovasc Dis. 2010;20(4):258-65. PubMed PMID: 19748247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plant sterols from rapeseed and tall oils: effects on lipids, fat-soluble vitamins and plant sterol concentrations. AU - Heggen,E, AU - Granlund,L, AU - Pedersen,J I, AU - Holme,I, AU - Ceglarek,U, AU - Thiery,J, AU - Kirkhus,B, AU - Tonstad,S, Y1 - 2009/09/12/ PY - 2008/11/17/received PY - 2009/02/22/revised PY - 2009/04/01/accepted PY - 2009/9/15/entrez PY - 2009/9/15/pubmed PY - 2010/7/10/medline SP - 258 EP - 65 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 20 IS - 4 N2 - BACKGROUND AND AIMS: Data comparing the impact of different sources of plant sterols on CVD risk factors and antioxidant levels is scarce. We evaluated the effects of plant sterols from rapeseed and tall oils on serum lipids, lipoproteins, fat-soluble vitamins and plant sterol concentrations. METHODS AND RESULTS: This was a double-blinded, randomized, crossover trial in which 59 hypercholesterolemic subjects consumed 25 g/day of margarine for 4 weeks separated by 1 week washout periods. The two experimental margarines provided 2g/day of plant sterols from rapeseed or tall oil. The control margarine had no added plant sterols. The control margarine reduced LDL cholesterol by 4.5% (95% CI 1.4, 7.6%). The tall and rapeseed sterol margarines additionally reduced LDL cholesterol by 9.0% (95% CI 5.5, 12.4%) and 8.2% (95% CI 5.2, 11.4%) and apolipoprotein B by 5.3% (95% CI 1.0, 9.6%) and 6.9% (95% CI 3.6, 10.2%), respectively. Lipid-adjusted beta-carotene concentrations were reduced by both sterol margarines (P<0.017). alpha-Tocopherol concentrations were reduced by the tall sterol compared to the rapeseed sterol margarine (P=0.001). Campesterol concentrations increased more markedly with the rapeseed sterol versus tall sterol margarine (P<0.001). The rapeseed sterol margarine increased while the tall sterol margarine decreased brassicasterol concentrations (P<0.001). CONCLUSIONS: Plant sterols from tall and rapeseed oils reduce atherogenic lipids and lipoproteins similarly. The rapeseed sterol margarine may have more favorable effects on serum alpha-tocopherol concentrations. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/19748247/Plant_sterols_from_rapeseed_and_tall_oils:_effects_on_lipids_fat_soluble_vitamins_and_plant_sterol_concentrations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(09)00095-7 DB - PRIME DP - Unbound Medicine ER -