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Carbohydrate restriction favorably alters lipoprotein metabolism in Emirati subjects classified with the metabolic syndrome.
Nutr Metab Cardiovasc Dis. 2010 Dec; 20(10):720-6.NM

Abstract

BACKGROUND AND AIMS

Carbohydrate restriction (CR) has been shown to improve dyslipidemias associated with metabolic syndrome (MetS). We evaluated the effects of CR on lipoprotein subfractions and apolipoproteins in Emirati adults classified with the MetS.

METHODS AND RESULTS

39 subjects (15 men/24 women) were randomly allocated to a CR diet [20-25% energy from carbohydrate (CHO)] for 12 wk (CRD group) or a combination treatment consisting of CRD for 6 wk followed by the American Heart Association diet (50-55% CHO, AHA group) for an additional 6 wk. All subjects reduced body weight, LDL cholesterol and triglycerides (P<0.01). At baseline all subjects had low concentrations of medium VLDL and total HDL particles associated with the very low plasma triglycerides and HDL cholesterol in this population. After 12 wk, the large VLDL subfraction was decreased over time for subjects in the CRD group (P<0.01) while these changes were not observed in those subjects who changed to the AHA diet. The number of medium and small LDL particles decreased for all subjects rendering a less atherogenic lipoprotein profile. In agreement with these results, a significant decrease in apolipoprotein (apo) B was observed (P<0.01). The medium HDL subfraction and apo A-II, which can be considered pro-atherogenic, were also decreased over time in the CRD group only.

CONCLUSIONS

These results suggest that weight loss favorably affects lipoprotein metabolism and that the CRD had a better effect on atherogenic VLDL and HDL than the low fat diet recommended by AHA.

Authors+Show Affiliations

Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19748249

Citation

Al-Sarraj, T, et al. "Carbohydrate Restriction Favorably Alters Lipoprotein Metabolism in Emirati Subjects Classified With the Metabolic Syndrome." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 20, no. 10, 2010, pp. 720-6.
Al-Sarraj T, Saadi H, Volek JS, et al. Carbohydrate restriction favorably alters lipoprotein metabolism in Emirati subjects classified with the metabolic syndrome. Nutr Metab Cardiovasc Dis. 2010;20(10):720-6.
Al-Sarraj, T., Saadi, H., Volek, J. S., & Fernandez, M. L. (2010). Carbohydrate restriction favorably alters lipoprotein metabolism in Emirati subjects classified with the metabolic syndrome. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 20(10), 720-6. https://doi.org/10.1016/j.numecd.2009.06.004
Al-Sarraj T, et al. Carbohydrate Restriction Favorably Alters Lipoprotein Metabolism in Emirati Subjects Classified With the Metabolic Syndrome. Nutr Metab Cardiovasc Dis. 2010;20(10):720-6. PubMed PMID: 19748249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbohydrate restriction favorably alters lipoprotein metabolism in Emirati subjects classified with the metabolic syndrome. AU - Al-Sarraj,T, AU - Saadi,H, AU - Volek,J S, AU - Fernandez,M L, Y1 - 2009/09/12/ PY - 2009/03/10/received PY - 2009/06/04/revised PY - 2009/06/08/accepted PY - 2009/9/15/entrez PY - 2009/9/15/pubmed PY - 2011/5/20/medline SP - 720 EP - 6 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 20 IS - 10 N2 - BACKGROUND AND AIMS: Carbohydrate restriction (CR) has been shown to improve dyslipidemias associated with metabolic syndrome (MetS). We evaluated the effects of CR on lipoprotein subfractions and apolipoproteins in Emirati adults classified with the MetS. METHODS AND RESULTS: 39 subjects (15 men/24 women) were randomly allocated to a CR diet [20-25% energy from carbohydrate (CHO)] for 12 wk (CRD group) or a combination treatment consisting of CRD for 6 wk followed by the American Heart Association diet (50-55% CHO, AHA group) for an additional 6 wk. All subjects reduced body weight, LDL cholesterol and triglycerides (P<0.01). At baseline all subjects had low concentrations of medium VLDL and total HDL particles associated with the very low plasma triglycerides and HDL cholesterol in this population. After 12 wk, the large VLDL subfraction was decreased over time for subjects in the CRD group (P<0.01) while these changes were not observed in those subjects who changed to the AHA diet. The number of medium and small LDL particles decreased for all subjects rendering a less atherogenic lipoprotein profile. In agreement with these results, a significant decrease in apolipoprotein (apo) B was observed (P<0.01). The medium HDL subfraction and apo A-II, which can be considered pro-atherogenic, were also decreased over time in the CRD group only. CONCLUSIONS: These results suggest that weight loss favorably affects lipoprotein metabolism and that the CRD had a better effect on atherogenic VLDL and HDL than the low fat diet recommended by AHA. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/19748249/Carbohydrate_restriction_favorably_alters_lipoprotein_metabolism_in_Emirati_subjects_classified_with_the_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(09)00143-4 DB - PRIME DP - Unbound Medicine ER -